Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Elepsia XR
  2. Keppra
  3. Keppra XR

Descriptions


Levetiracetam is used alone or together with other medicines to help control certain types of seizures (eg, partial seizures, myoclonic seizures, or tonic-clonic seizures) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to use it.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet, Extended Release
  • Tablet
  • Tablet for Suspension
  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of levetiracetam oral solution, tablets, or tablets for suspension in children younger than 1 month of age (Keppra®) or in children younger than 4 years of age and weighing less than 20 kilograms (Spritam®, Spritam® tablets for oral suspension), and levetiracetam extended-release tablets in children younger than 12 years of age (Elepsia™ XR) or (Keppra XR®). Safety and efficacy have not been established in these age groups.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of levetiracetam in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving levetiracetam.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Apixaban
  • Calcifediol
  • Dabigatran Etexilate Mesylate
  • Edoxaban
  • Levoketoconazole
  • Methotrexate
  • Orlistat
  • Rivaroxaban

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Ginkgo

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Depression, history of or
  • Hypertension (high blood pressure) or
  • Mental illness, history of—Use with caution. May make these conditions worse.
  • Kidney disease, moderate to severe—Use is not recommended in patients with this condition.
  • Kidney problems—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine only as directed by your doctor, to help your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not change your dose without checking first with your doctor.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Levetiracetam may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed. You should try to take this medicine at the same time each day.

Swallow the tablet or the extended-release tablet whole. Do not break, crush, or chew it. There is an oral liquid form of this medicine if you or your child cannot swallow the tablets.

Elepsia™ XR extended-release tablet has a blue and white to off-white layer. If you do not see the blue or white, off-white layer, do not take the tablet.

A part of the tablet may also pass into your stool. This is normal and is nothing to worry about.

If you are using the Spritam® tablet or the Spritam® tablet for suspension, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet on your tongue and take a sip of water. After it has melted, swallow.

You may also add one whole Spritam® tablet for suspension to a small volume of liquid in a cup (1 tablespoon or enough to cover the medicine), and swirl gently. Swallow right away after it has dissolved. Then add a small volume of liquid to cup again, swirl gently, and swallow the liquid.

Measure the oral liquid with a marked measuring spoon, dropper, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. If you have any questions about this, ask your doctor or pharmacist.

This medicine can be used with other seizure medicines. Keep using all of your seizure medicines unless your doctor tells you otherwise.

Take only the form of this medicine that your doctor prescribed. If you refill your prescription and your pills look different, do not take the medicine and tell your doctor or pharmacist right away.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release tablets):
    • For treatment of partial-onset seizures:
      • Adults and children 12 years of age and older and weighing 50 kilograms (kg) or more—At first, 1000 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (Keppra® solution or tablets):
    • For partial onset seizures:
      • Adults and children 16 years of age and older—At first, 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children 4 to 15 years of age—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 10 milligrams (mg) per kilogram (kg) of body weight 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 60 mg per kg of body weight per day.
      • Children 6 months to 3 years of age—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 10 mg per kg of body weight 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 50 mg per kg of body weight per day.
      • Children 1 to 5 months of age—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 7 mg per kg of body weight 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 42 mg per kg of body weight per day.
      • Children younger than 1 month of age—Use and dose must be determined by your doctor.
    • For juvenile myoclonic seizures:
      • Children 12 years of age and older—At first, 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For primary generalized tonic-clonic seizures:
      • Adults and children 16 years of age and older—At first, 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children 6 to 15 years of age—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 10 milligrams (mg) per kilogram (kg) of body weight 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 60 mg per kg of body weight per day.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.
  • For oral dosage forms (Spritam® tablets, Spritam® tablets for suspension):
    • For partial onset seizures:
      • Adults and children 4 years of age and older weighing over 40 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children 4 years of age and older weighing 20 to 40 kg—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 250 mg 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 1500 mg per day.
      • Children younger than 4 years of age and weighing less than 20 kg—Use is not recommended.
    • For juvenile myoclonic seizures:
      • Children 12 years of age and older—At first, 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For primary generalized tonic-clonic seizures:
      • Adults and children 6 years of age and older weighing over 40 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day.
      • Children 6 years of age and older weighing 20 to 40 kg—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 250 mg 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 1500 mg per day.
      • Children younger than 6 years of age and weighing less than 20 kg—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your or your child's progress at regular visits, especially for the first few months you or your child are using this medicine. This is to see if the medicine is working properly and to allow for a change in the dose. Blood tests may be needed to check for any unwanted effects.

It is important to tell your doctor if you become pregnant while using this medicine. Your doctor may want you to join a pregnancy registry for patients taking a seizure medicine.

Levetiracetam may cause changes in mood or behavior, problems with coordination, or unusual tiredness or weakness. Tell your doctor right away if you or your child start to feel depressed, anxious, angry, getting upset easily, restless, or have thoughts about hurting yourself. Report any unusual thoughts or behavior that trouble you, especially if they are new or getting worse quickly.

This medicine may cause some people to become dizzy, drowsy, tired, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine may cause serious allergic reactions, including anaphylaxis or angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) can occur with this medicine. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness while you are using this medicine.

Do not stop using levetiracetam without first checking with your doctor. Stopping the medicine suddenly may cause your seizures to return or to occur more often. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Aggressive or angry
  2. anxiety
  3. change in personality
  4. chills
  5. cough
  6. crying
  7. deep or fast breathing with dizziness
  8. delusions of persecution, mistrust, suspiciousness, or combativeness
  9. diarrhea
  10. dry mouth
  11. false or unusual sense of well-being
  12. feeling of unreality
  13. fever
  14. general feeling of discomfort or illness
  15. headache
  16. hoarseness
  17. irregular heartbeat
  18. irritability
  19. joint pain
  20. loss of appetite
  21. lower back or side pain
  22. mental depression
  23. muscle aches and pains
  24. nausea
  25. numbness of the feet, hands, and around the mouth
  26. painful or difficult urination
  27. quick to react or overreact emotionally
  28. rapidly changing moods
  29. restlessness
  30. sense of detachment from self or body
  31. shaking
  32. shivering
  33. sleepiness or unusual drowsiness
  34. sore throat
  35. stuffy or runny nose
  36. sweating
  37. trouble sleeping
  38. unusual tiredness or weakness
  39. vomiting

Less common

  1. Bloody nose
  2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  3. clumsiness or unsteadiness
  4. discouragement
  5. dizziness or lightheadedness
  6. double vision
  7. earache
  8. feeling of constant movement of self or surroundings
  9. feeling sad or empty
  10. increase in body movements
  11. loss of bladder control
  12. loss of memory
  13. mood or mental changes
  14. outburst of anger
  15. pain or tenderness around the eyes and cheekbones
  16. problems with memory
  17. redness or swelling in the ear
  18. seizures
  19. sensation of spinning
  20. shakiness and unsteady walk
  21. shakiness in the legs, arms, hands, or feet
  22. tightness of the chest
  23. trembling or shaking of the hands or feet
  24. trouble concentrating
  25. unsteadiness, trembling, or other problems with muscle control or coordination

Incidence not known

  1. Agitation
  2. attempts at killing oneself
  3. being forgetful
  4. bleeding gums
  5. blistering, peeling, or loosening of the skin
  6. bloating
  7. blood in the urine or stools
  8. bloody, black, or tarry stools
  9. blurred vision
  10. changes in vision
  11. chest pain
  12. coma
  13. confusion
  14. constipation
  15. dark urine
  16. decreased urine output
  17. difficulty with moving
  18. fast heartbeat
  19. fever with or without chills
  20. general feeling of tiredness or weakness
  21. high fever
  22. hostility
  23. increased thirst
  24. indigestion
  25. itching
  26. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  27. lethargy
  28. light-colored stools
  29. muscle pains, stiffness, or twitching
  30. pains in the stomach, side, or abdomen, possibly radiating to the back
  31. pale skin
  32. pinpoint red spots on the skin
  33. red skin lesions, often with a purple center
  34. red, irritated eyes
  35. skin rash, encrusted, scaly, and oozing
  36. sores, ulcers, or white spots on the lips or in the mouth
  37. stomach pain, continuing
  38. stupor
  39. swelling of the face, ankles, or hands
  40. swollen glands
  41. swollen joints
  42. thoughts or attempts at killing oneself
  43. trouble with balance
  44. twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  45. uncontrolled jerking or twisting movements of the hands, arms, or legs
  46. uncontrolled movements of the lips, tongue, or cheeks
  47. unexplained bleeding or bruising
  48. unusual bleeding or bruising
  49. upper right abdominal or stomach pain
  50. weight loss
  51. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Loss of strength or energy
  2. muscle pain or weakness
  3. pain
  4. tender, swollen glands in the neck
  5. trouble swallowing
  6. unusual weak feeling
  7. voice changes

Less common

  1. Body aches or pain
  2. burning, dry, or itching eyes
  3. change in the color of the skin
  4. congestion
  5. cough increased
  6. sneezing

Incidence not known

  1. Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.