Before Using

Drug information provided by: IBM Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of leuprolide pediatric injection in children. However, use is not recommended in children younger than 2 years of age. Leuprolide pediatric injection will stop having an effect for central precocious puberty soon after the child stops using it, and puberty will advance normally.

Appropriate studies have not been performed on the relationship of age to the effects of Eligard®, Lupron®, Lupron Depot®, Lupron Depot®-3 month, Lupron Depot®-4 month, Lupron Depot®-6 month, Lupron Depot® 11.25 mg, or Viadur® in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Eligard®, Lupron®, Lupron Depot®, Lupron Depot®-3 month, Lupron Depot®-4 month, or Lupron Depot®-6 month in the elderly.

Appropriate studies on the relationship of age to the effects of Lupron Depot® 11.25 mg have not been performed in the geriatric population. This medicine is not indicated for use in elderly women.

No information is available on the relationship of age to the effects of Fensolvi®, Lupron Depot-Ped® or Viadur® in the elderly.


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Dronedarone
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Amisulpride
  • Aripiprazole Lauroxil
  • Buprenorphine
  • Buserelin
  • Ceritinib
  • Citalopram
  • Clofazimine
  • Degarelix
  • Deslorelin
  • Deutetrabenazine
  • Donepezil
  • Encorafenib
  • Entrectinib
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Histrelin
  • Hydroxychloroquine
  • Hydroxyzine
  • Inotuzumab Ozogamicin
  • Ivosidenib
  • Lefamulin
  • Lenvatinib
  • Lofexidine
  • Macimorelin
  • Methotrimeprazine
  • Moricizine
  • Nafarelin
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Papaverine
  • Pimavanserin
  • Pitolisant
  • Ribociclib
  • Selpercatinib
  • Sertraline
  • Siponimod
  • Sotalol
  • Sulpiride
  • Triclabendazole
  • Triptorelin
  • Vemurafenib
  • Zotepine
  • Zuclopenthixol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abnormal or unusual vaginal bleeding—Lupron Depot® 11.25 mg injection should not be used in patients with this condition.
  • Asthma or history of or
  • Brain tumors, history of or
  • Congestive heart failure or
  • Drug allergy or history of or
  • Electrolyte imbalance (eg, low magnesium, potassium, or calcium) or
  • Heart attack, history of or
  • Heart or blood vessel disease or
  • Heart rhythm problems (eg, congenital long QT syndrome) or
  • Seizures or epilepsy, history of or
  • Sinusitis or history of or
  • Stroke, history of—Use with caution. May cause side effects to become worse.
  • Benzyl alcohol allergy—One of the Lupron® injection products for children may cause an allergic reaction.
  • Depression, history of or
  • Diabetes or
  • Hyperglycemia (high sugar in the blood) or
  • Mental illness, history of or
  • Osteoporosis (thinning of the bones)—Use with caution. May make these conditions worse.