Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Optiray™ 350 and Optiray™ 320 for angiography, and Optiray™ 320 for CT scan of the head and body in children. However, safety and efficacy have not been established in newborns.

Geriatric

Appropriate studies on the relationship of age to the effects of ioversol injection have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Metformin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergic rhinitis (hay fever) or
  • Allergy to a contrast agent, history of or
  • Allergy to iodine or
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Anuria (not able to pass urine) or
  • Blood vessel disease, severe or
  • Congestive heart failure or
  • Dehydration or
  • Diabetes or
  • Kidney disease or
  • Multiple myeloma (cancer of plasma cells) or
  • Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
  • Blood clotting problems (eg, phlebitis, thrombosis) or
  • Heart or blood vessel disease (eg, arteriosclerosis) or
  • Hypertension (high blood pressure) or
  • Kidney disease, severe or
  • Liver disease or
  • Pheochromocytoma (adrenal problem) or
  • Sickle cell disease (inherited blood disorder)—Use with caution. May make these conditions worse.
  • Homocystinuria (genetic disease)—Patients with this condition should avoid undergoing angiography because of the increase risk of having blood clotting problems.
  • Hyperthyroidism (overactive thyroid)—Should not be used in patients with this condition.