Description and Brand Names

Drug information provided by: Micromedex

Descriptions


Iohexol injection is used to help diagnose or find problems in the brain, back, heart, head, blood vessels, and other parts of the body. It is an iodinated contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during certain medical procedures (eg, CT scans).

This medicine is to be given only by or under the supervision of a doctor.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of iohexol in children. Some pediatric patients with certain medical conditions (eg, asthma, heart failure, kidney problems) may have more unwanted side effects which may require caution in patients receiving iohexol.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of iohexol in the elderly. However, elderly patients are more likely to have unwanted side effects which may require caution and an adjustment in the dose for patients receiving iohexol.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Amiodarone
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Esmolol
  • Labetalol
  • Levobunolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Practolol
  • Propranolol
  • Sotalol
  • Timolol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Heart or blood vessel disease—Iohexol injection should be used with caution in these patients.
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Congestive heart failure or
  • Dehydration or
  • Diabetes or
  • Kidney disease or
  • Multiple myeloma (cancer of plasma cells) or
  • Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
  • Heart or blood vessel disease or
  • Hypertension (high blood pressure) or
  • Hyperthyroidism (overactive thyroid) or
  • Kidney disease, severe or
  • Liver disease or
  • Pheochromocytoma (adrenal problem) or
  • Sickle cell anemia (inherited blood disorder)—Use with caution. May make these conditions worse.

Proper Use

A doctor or other trained health professional will give you this medicine in a hospital. It is given through a needle placed into a vein.

Your doctor may also give you medicines (eg, allergy medicine, steroids) to prevent allergic reactions.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine may cause a heart attack. Tell your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, or coughing up blood.

Severe kidney problems may occur after receiving this medicine. Tell your doctor right away if you have the following symptoms after receiving the medicine: agitation, confusion, decreased urine output, dizziness, headache, muscle twitching, rapid weight gain, or swelling of the face, ankles, or hands.

This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a skin rash, itching, shortness of breath, sweating, swelling of the face, tongue, and throat, or tightness in the chest after you receive this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine.

Make sure your doctor knows if you have had an allergic reaction to any dye or medicine given during a test or procedure.

While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

Make sure any doctor or dentist who treats you knows that you are using iohexol injection. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. You should not receive iohexol injection together with a steroid medicine into your spinal cord.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  1. Arm, back, or jaw pain
  2. chest pain, discomfort, tightness, or heaviness
  3. difficulty breathing
  4. dizziness
  5. fainting
  6. fast, slow, or irregular heartbeat
  7. nausea
  8. sweating
  9. swelling in the throat

Rare

  1. Blurred vision
  2. confusion
  3. dilated neck veins
  4. dizziness or lightheadedness
  5. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  6. extreme tiredness or weakness
  7. fast, pounding, or irregular heartbeat or pulse
  8. feeling cold
  9. feeling of constant movement of self or surroundings
  10. fever
  11. irregular breathing
  12. pale skin
  13. seizures
  14. sensation of spinning
  15. swelling of the face, fingers, feet, or lower legs
  16. troubled breathing with exertion
  17. unusual bleeding or bruising
  18. unusual tiredness or weakness
  19. weight gain

Incidence not known

  1. Agitation
  2. black, tarry stools
  3. blistering, peeling, or loosening of the skin
  4. bloating
  5. bluish color of the fingernails, lips, skin, palms, or nail beds
  6. changes in skin color, pain, tenderness, or swelling of the foot or leg
  7. chest pain or discomfort
  8. chills
  9. constipation
  10. cough
  11. darkened urine
  12. decreased urine output
  13. diarrhea
  14. difficulty swallowing
  15. discouragement
  16. drowsiness
  17. feeling sad or empty
  18. headache
  19. hives, itching, skin rash
  20. indigestion
  21. irritability
  22. joint or muscle pain
  23. lack of appetite
  24. loss of consciousness
  25. loss of interest or pleasure
  26. lower back or side pain
  27. mood or mental changes
  28. muscle twitching
  29. nervousness
  30. pain or discomfort in the arms, jaw, back, or neck
  31. painful or difficult urination
  32. pains in the stomach, side, or abdomen, possibly radiating to the back
  33. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  34. rapid weight gain
  35. red, irritated eyes
  36. red skin lesions, often with a purple center
  37. seeing, hearing, or feeling things that are not there
  38. sensitivity to heat
  39. sore throat
  40. sores, ulcers, or white spots in the mouth or on the lips
  41. stiff neck
  42. temporary vision loss
  43. throat irritation or tightness
  44. trouble concentrating
  45. trouble sleeping
  46. unusual bleeding or bruising
  47. unusual drowsiness, dullness, or feeling of sluggishness
  48. vomiting
  49. weight loss
  50. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Bad, unusual, or unpleasant (after) taste
  2. change in taste

Rare

  1. Anxiety
  2. belching
  3. cold sweats
  4. dry mouth
  5. heartburn
  6. increased hunger
  7. indigestion
  8. nightmares
  9. redness of the skin
  10. runny nose
  11. shakiness
  12. sleepiness or unusual drowsiness
  13. slurred speech
  14. sneezing
  15. stomach discomfort, upset, or pain
  16. stuffy nose
  17. uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.