Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of insulin degludec and liraglutide combination injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of insulin degludec and liraglutide combination injection in the elderly. However, elderly patients are more likely to have age-related hypoglycemia, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Acarbose
  • Acetohexamide
  • Alogliptin
  • Bexagliflozin
  • Bromocriptine
  • Canagliflozin
  • Chloroquine
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Ciprofloxacin
  • Dapagliflozin
  • Delafloxacin
  • Empagliflozin
  • Enoxacin
  • Ertugliflozin
  • Furosemide
  • Gatifloxacin
  • Gemifloxacin
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Grepafloxacin
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Hydroxychloroquine
  • Indapamide
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Lanreotide Acetate
  • Levofloxacin
  • Linagliptin
  • Liraglutide
  • Lomefloxacin
  • Macimorelin
  • Metformin
  • Metoclopramide
  • Metolazone
  • Metreleptin
  • Miglitol
  • Moxifloxacin
  • Nateglinide
  • Norfloxacin
  • Octreotide Acetate
  • Ofloxacin
  • Pasireotide Diaspartate
  • Pioglitazone
  • Polythiazide
  • Pramlintide
  • Repaglinide
  • Rosiglitazone
  • Semaglutide
  • Sitagliptin
  • Somatrogon-ghla
  • Sotagliflozin
  • Sparfloxacin
  • Testosterone
  • Thioctic Acid
  • Tolazamide
  • Tolbutamide
  • Triamterene
  • Trovafloxacin
  • Vildagliptin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Albiglutide
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Dulaglutide
  • Esmolol
  • Exenatide
  • Glecaprevir
  • Isocarboxazid
  • Labetalol
  • Levobunolol
  • Linezolid
  • Lixisenatide
  • Methylene Blue
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Ozanimod
  • Penbutolol
  • Phenelzine
  • Pibrentasvir
  • Pindolol
  • Practolol
  • Procarbazine
  • Propranolol
  • Rasagiline
  • Safinamide
  • Saxagliptin
  • Selegiline
  • Semaglutide
  • Sotalol
  • Timolol
  • Tirzepatide
  • Tranylcypromine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Cholelithiasis (gallstones), history of or
  • Pancreatitis (swelling of the pancreas)—May increase risk for pancreatitis.
  • Angioedema (swelling of the face, lips, tongue, throat, arms, or legs) caused by GLP-1 receptor agonists, history of—Use with caution. May increase the risk of this condition occurring again.
  • Dehydration or
  • Gastroparesis (stomach does not empty food normally) or
  • Kidney disease (eg, chronic kidney failure), severe or
  • Pancreatitis, history of—Use with caution. May make these conditions worse.
  • Hypoglycemia (low blood sugar)—Should not be used during episodes of hypoglycemia. If you have low blood sugar and take insulin, your blood sugar may reach dangerously low levels.
  • Hypokalemia (low potassium in the blood)—May make this condition worse and increase your chance of having serious side effects.
  • Kidney disease, mild to moderate—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.
  • Medullary thyroid carcinoma (cancer of the thyroid), family history of or
  • Multiple endocrine neoplasia syndrome type 2 (MEN 2)—Should not be used in patients with these conditions.

Portions of this document last updated: April 01, 2024

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