Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of hydromorphone in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydromorphone in the elderly. However, elderly patients may be more sensitive to the effects of hydromorphone than younger adults, and are more likely to have age-related lung, liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving hydromorphone.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Nalmefene
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Naltrexone
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Safinamide
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Samidorphan
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Acepromazine
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Aclidinium
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Alfentanil
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Almotriptan
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Alprazolam
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Amantadine
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Amifampridine
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Amiloride
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Amineptine
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Amitriptyline
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Amitriptylinoxide
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Amobarbital
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Amoxapine
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Amphetamine
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Anileridine
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Aripiprazole
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Aripiprazole Lauroxil
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Asenapine
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Atropine
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Baclofen
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Belladonna
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Bemetizide
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Bendroflumethiazide
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Benperidol
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Bentazepam
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Benzhydrocodone
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Benzphetamine
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Benzthiazide
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Benztropine
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Biperiden
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Bromazepam
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Bromopride
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Brompheniramine
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Bumetanide
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Buprenorphine
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Bupropion
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Buspirone
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Butabarbital
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Butalbital
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Butorphanol
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Calcium Oxybate
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Cannabidiol
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Cannabis
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Canrenoate
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Canrenone
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Carbamazepine
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Carbinoxamine
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Carisoprodol
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Carphenazine
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Cetirizine
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Chloral Hydrate
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Chlordiazepoxide
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Chlorothiazide
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Chlorpheniramine
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Chlorpromazine
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Chlorthalidone
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Chlorzoxazone
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Citalopram
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Clemastine
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Clidinium
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Clobazam
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Clomipramine
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Clonazepam
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Clopamide
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Clopidogrel
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Clorazepate
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Cloxazolam
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Clozapine
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Cocaine
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Codeine
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Cyclobenzaprine
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Cyclopenthiazide
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Cyclopentolate
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Cyclothiazide
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Cyproheptadine
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Dantrolene
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Daridorexant
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Darifenacin
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Delorazepam
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Desipramine
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Desmopressin
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Desvenlafaxine
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Dexmedetomidine
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Dextroamphetamine
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Dextromethorphan
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Dezocine
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Diacetylmorphine
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Diazepam
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Diazoxide
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Dibenzepin
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Dichloralphenazone
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Dicyclomine
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Difenoxin
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Dihydrocodeine
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Dimenhydrinate
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Diphenhydramine
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Diphenoxylate
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Dolasetron
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Donepezil
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Doxepin
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Doxylamine
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Droperidol
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Duloxetine
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Eletriptan
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Enflurane
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Eplerenone
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Escitalopram
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Esketamine
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Estazolam
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Eszopiclone
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Ethacrynic Acid
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Ethchlorvynol
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Ethopropazine
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Ethylmorphine
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Etozolin
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Fenfluramine
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Fentanyl
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Fesoterodine
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Flavoxate
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Flibanserin
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Flunitrazepam
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Fluoxetine
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Fluphenazine
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Flurazepam
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Fluspirilene
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Fluvoxamine
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Fospropofol
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Frovatriptan
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Furosemide
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Gabapentin
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Gabapentin Enacarbil
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Gepirone
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Glycopyrrolate
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Glycopyrronium Tosylate
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Granisetron
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Halazepam
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Haloperidol
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Halothane
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Hexobarbital
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Homatropine
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Hydrochlorothiazide
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Hydrocodone
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Hydroflumethiazide
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Hydroxytryptophan
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Hydroxyzine
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Hyoscyamine
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Imipramine
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Indapamide
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Ipratropium
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Isocarboxazid
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Isoflurane
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Ketamine
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Ketazolam
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Ketobemidone
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Lacosamide
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Lasmiditan
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Lemborexant
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Levocetirizine
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Levomilnacipran
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Levorphanol
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Linezolid
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Lisdexamfetamine
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Lithium
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Lofepramine
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Lofexidine
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Loprazolam
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Lorazepam
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Lorcaserin
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Lormetazepam
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Loxapine
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Magnesium Oxybate
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Meclizine
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Medazepam
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Melitracen
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Melperone
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Mepenzolate
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Meperidine
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Mephobarbital
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Meprobamate
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Meptazinol
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Mesoridazine
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Metaclazepam
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Metaxalone
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Methadone
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Methamphetamine
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Methdilazine
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Methocarbamol
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Methohexital
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Methotrimeprazine
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Methyclothiazide
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Methylene Blue
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Metoclopramide
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Metolazone
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Midazolam
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Milnacipran
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Mirtazapine
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Molindone
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Moricizine
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Morphine
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Morphine Sulfate Liposome
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Nalbuphine
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Naratriptan
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Nefazodone
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Nicomorphine
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Nitrazepam
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Nitrous Oxide
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Nordazepam
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Nortriptyline
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Olanzapine
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Oliceridine
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Ondansetron
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Opipramol
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Opium
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Opium Alkaloids
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Orphenadrine
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Oxazepam
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Oxitropium Bromide
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Oxybutynin
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Oxycodone
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Oxymorphone
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Ozanimod
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Palonosetron
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Papaveretum
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Paregoric
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Paroxetine
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Pentazocine
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Pentobarbital
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Perampanel
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Perazine
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Periciazine
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Perphenazine
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Phenelzine
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Phenobarbital
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Pimozide
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Pinazepam
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Pipenzolate Bromide
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Piperacetazine
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Pipotiazine
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Pirenzepine
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Piretanide
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Piritramide
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Polythiazide
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Potassium Oxybate
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Prazepam
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Pregabalin
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Primidone
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Procarbazine
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Prochlorperazine
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Procyclidine
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Promazine
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Promethazine
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Propantheline
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Propiverine
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Propofol
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Protriptyline
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Quazepam
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Quetiapine
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Quinethazone
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Ramelteon
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Rasagiline
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Remifentanil
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Remimazolam
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Remoxipride
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Rizatriptan
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Ropeginterferon Alfa-2b-njft
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Scopolamine
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Secobarbital
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Selegiline
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Sertindole
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Sertraline
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Sibutramine
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Sodium Oxybate
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Solifenacin
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Spironolactone
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St John's Wort
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Stramonium
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Sufentanil
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Sulpiride
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Sumatriptan
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Suvorexant
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Tapentadol
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Temazepam
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Terodiline
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Tetrazepam
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Thiethylperazine
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Thiopental
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Thiopropazate
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Thioridazine
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Thiothixene
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Tianeptine
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Ticagrelor
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Tilidine
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Tiotropium
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Tizanidine
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Tolonium Chloride
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Tolterodine
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Topiramate
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Torsemide
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Tramadol
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Tranylcypromine
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Trazodone
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Triamterene
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Triazolam
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Trichlormethiazide
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Trifluoperazine
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Trifluperidol
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Triflupromazine
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Trihexyphenidyl
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Trimeprazine
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Trimipramine
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Tropicamide
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Trospium
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Tryptophan
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Umeclidinium
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Venlafaxine
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Vilazodone
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Vortioxetine
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Xipamide
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Zaleplon
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Ziprasidone
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Zolmitriptan
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Zolpidem
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Zopiclone
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Zotepine
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Zuranolone
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Addison disease (adrenal gland problem) or
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Alcohol abuse, or history of or
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Brain tumor or
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Breathing or lung problems (eg, apnea, low oxygen levels) or
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Chronic obstructive pulmonary disease (COPD) or
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Cor pulmonale (serious heart condition) or
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Depression, history of or
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Drug dependence, especially narcotic abuse or dependence, history of or
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Gallbladder disease or
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Head injury, history of or
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Hypothyroidism (an underactive thyroid) or
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Mental health problems, or history of or
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Obesity, severe or
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Prostatic hypertrophy (enlarged prostate, BPH) or
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Weakened physical condition—Use with caution. May increase risk for more serious side effects.
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Allergy to sulfites or
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Asthma, acute or severe or
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Lung or breathing problems (eg, respiratory depression), severe or
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Narrowing of the stomach or bowels ("blind loops") or
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Stomach or bowel blockage (eg, paralytic ileus), known or suspected—Should not be used in patients with these conditions.
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Hypotension (low blood pressure) or
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Pancreatitis (swelling of the pancreas) or
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Seizures, history of—Use with caution. May make these conditions worse.
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Kidney disease or
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Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.