Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
The use of hydrocodone in children younger than 6 years old has caused serious breathing problems, sometimes causing death. Hydrocodone and chlorpheniramine combination is not indicated for use in children younger than 18 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydrocodone and chlorpheniramine combination in the elderly. However, elderly patients are more likely to develop age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Naltrexone
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Potassium Citrate
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Safinamide
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Samidorphan
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Tranylcypromine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abametapir
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Acepromazine
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Aclidinium
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Alfentanil
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Almotriptan
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Alprazolam
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Amantadine
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Amifampridine
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Amiloride
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Amineptine
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Amiodarone
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Amitriptyline
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Amitriptylinoxide
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Amobarbital
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Amoxapine
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Amphetamine
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Amprenavir
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Anileridine
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Apalutamide
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Aprepitant
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Aripiprazole
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Aripiprazole Lauroxil
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Armodafinil
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Asenapine
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Atazanavir
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Atropine
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Avacopan
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Baclofen
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Belladonna
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Belzutifan
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Bemetizide
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Bendroflumethiazide
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Benperidol
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Bentazepam
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Benzhydrocodone
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Benzphetamine
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Benzthiazide
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Benztropine
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Berotralstat
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Biperiden
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Boceprevir
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Bosentan
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Bromazepam
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Bromopride
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Brompheniramine
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Bumetanide
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Buprenorphine
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Bupropion
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Buspirone
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Butabarbital
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Butalbital
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Butorphanol
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Calcium Oxybate
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Cannabidiol
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Cannabis
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Canrenoate
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Canrenone
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Carbamazepine
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Carbinoxamine
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Carisoprodol
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Carphenazine
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Cenobamate
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Ceritinib
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Cetirizine
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Chloral Hydrate
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Chlordiazepoxide
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Chlorothiazide
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Chlorpheniramine
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Chlorpromazine
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Chlorthalidone
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Chlorzoxazone
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Cilostazol
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Cimetidine
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Ciprofloxacin
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Citalopram
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Clarithromycin
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Clemastine
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Clidinium
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Clobazam
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Clofazimine
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Clomipramine
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Clonazepam
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Clopamide
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Clopidogrel
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Clorazepate
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Cloxazolam
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Clozapine
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Cobicistat
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Cocaine
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Codeine
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Conivaptan
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Crizotinib
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Cyclobenzaprine
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Cyclopenthiazide
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Cyclopentolate
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Cyclosporine
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Cyclothiazide
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Cyproheptadine
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Dabrafenib
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Dantrolene
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Daridorexant
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Darifenacin
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Darunavir
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Dasabuvir
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Delavirdine
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Delorazepam
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Desipramine
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Desmopressin
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Desvenlafaxine
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Dexamethasone
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Dexmedetomidine
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Dextroamphetamine
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Dextromethorphan
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Dezocine
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Diacetylmorphine
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Diazepam
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Diazoxide
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Dibenzepin
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Dichloralphenazone
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Dicloxacillin
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Dicyclomine
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Difenoxin
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Dihydrocodeine
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Diltiazem
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Dimenhydrinate
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Diphenhydramine
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Diphenoxylate
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Dipyrone
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Dolasetron
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Donepezil
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Doxepin
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Doxylamine
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Dronedarone
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Droperidol
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Duloxetine
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Duvelisib
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Efavirenz
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Elagolix
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Eletriptan
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Enflurane
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Enzalutamide
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Eplerenone
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Erythromycin
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Escitalopram
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Esketamine
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Eslicarbazepine Acetate
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Estazolam
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Eszopiclone
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Ethacrynic Acid
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Ethchlorvynol
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Ethopropazine
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Ethylmorphine
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Etozolin
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Etravirine
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Fedratinib
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Fenfluramine
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Fentanyl
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Fesoterodine
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Fexinidazole
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Flavoxate
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Flibanserin
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Fluconazole
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Flunitrazepam
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Fluoxetine
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Fluphenazine
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Flurazepam
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Fluspirilene
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Fluvoxamine
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Fosamprenavir
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Fosaprepitant
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Fosnetupitant
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Fosphenytoin
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Fospropofol
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Frovatriptan
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Furosemide
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Gabapentin
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Gabapentin Enacarbil
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Gepirone
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Glucagon
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Glycopyrrolate
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Glycopyrronium Tosylate
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Granisetron
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Halazepam
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Haloperidol
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Halothane
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Hexobarbital
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Homatropine
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Hydrochlorothiazide
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Hydrocodone
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Hydroflumethiazide
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Hydromorphone
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Hydroxyamphetamine
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Hydroxytryptophan
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Hydroxyzine
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Hyoscyamine
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Idelalisib
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Imatinib
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Imipramine
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Indapamide
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Indinavir
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Ipratropium
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Isocarboxazid
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Isoflurane
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Itraconazole
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Ivacaftor
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Ivosidenib
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Ketamine
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Ketazolam
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Ketobemidone
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Ketoconazole
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Lacosamide
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Larotrectinib
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Lasmiditan
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Lemborexant
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Lenacapavir
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Lesinurad
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Letermovir
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LetibotulinumtoxinA-wlbg
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Levocetirizine
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Levomilnacipran
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Levorphanol
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Linezolid
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Lisdexamfetamine
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Lithium
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Lofepramine
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Lofexidine
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Lomitapide
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Lonafarnib
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Loprazolam
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Lorazepam
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Lorcaserin
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Lorlatinib
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Lormetazepam
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Loxapine
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Lumacaftor
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Magnesium Oxybate
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Maribavir
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Mavacamten
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Meclizine
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Medazepam
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Melitracen
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Melperone
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Mepenzolate
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Meperidine
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Mephobarbital
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Meprobamate
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Meptazinol
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Mesoridazine
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Metaclazepam
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Metaxalone
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Methacholine
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Methadone
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Methamphetamine
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Methdilazine
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Methocarbamol
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Methohexital
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Methotrimeprazine
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Methyclothiazide
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Methylene Blue
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Methylprednisolone
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Metoclopramide
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Metolazone
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Midazolam
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Mifepristone
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Milnacipran
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Mirtazapine
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Mitotane
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Mobocertinib
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Modafinil
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Molindone
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Moricizine
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Morphine
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Morphine Sulfate Liposome
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Nafcillin
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Nalbuphine
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Naratriptan
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Nefazodone
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Nelfinavir
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Netupitant
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Nevirapine
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Nicomorphine
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Nilotinib
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Nitrazepam
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Nitrous Oxide
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Nordazepam
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Nortriptyline
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Olanzapine
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Oliceridine
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Omaveloxolone
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Ombitasvir
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Ondansetron
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Opipramol
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Opium
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Opium Alkaloids
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Orphenadrine
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Oxazepam
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Oxcarbazepine
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Oxitropium Bromide
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Oxybutynin
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Oxycodone
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Oxymorphone
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Ozanimod
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Palbociclib
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Paliperidone
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Palonosetron
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Papaveretum
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Paregoric
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Paritaprevir
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Paroxetine
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Pentazocine
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Pentobarbital
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Perampanel
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Perazine
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Periciazine
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Perphenazine
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Phenelzine
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Phenobarbital
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Phenytoin
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Pimozide
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Pinazepam
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Pipenzolate Bromide
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Piperacetazine
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Pipotiazine
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Pirenzepine
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Piretanide
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Piritramide
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Pitolisant
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Polythiazide
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Posaconazole
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Potassium Oxybate
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Prazepam
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Prednisone
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Pregabalin
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Primidone
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Procarbazine
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Prochlorperazine
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Procyclidine
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Promazine
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Promethazine
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Propantheline
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Propiverine
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Propofol
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Protriptyline
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Quazepam
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Quetiapine
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Quinethazone
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Ramelteon
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Ranitidine
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Ranolazine
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Rasagiline
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Remifentanil
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Remimazolam
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Remoxipride
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Revefenacin
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Ribociclib
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Rifabutin
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Rifampin
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Rifapentine
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Ritlecitinib
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Ritonavir
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Rizatriptan
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Ropeginterferon Alfa-2b-njft
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Saquinavir
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Schisandra sphenanthera
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Scopolamine
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Secobarbital
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Secretin Human
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Selegiline
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Sertindole
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Sertraline
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Sibutramine
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Sodium Oxybate
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Sofpironium
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Solifenacin
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Spironolactone
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St John's Wort
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Stramonium
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Sufentanil
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Sulpiride
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Sumatriptan
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Suvorexant
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Tapentadol
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Tazemetostat
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Telaprevir
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Telithromycin
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Telotristat Ethyl
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Temazepam
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Terodiline
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Tetrazepam
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Thiethylperazine
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Thiopental
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Thiopropazate
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Thioridazine
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Thiothixene
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Tianeptine
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Ticagrelor
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Tilidine
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Tiotropium
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Tizanidine
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Tolonium Chloride
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Tolterodine
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Topiramate
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Torsemide
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Tramadol
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Tranylcypromine
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Trazodone
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Triamterene
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Triazolam
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Trichlormethiazide
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Trifluoperazine
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Trifluperidol
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Triflupromazine
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Trihexyphenidyl
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Trimeprazine
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Trimipramine
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Trofinetide
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Troleandomycin
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Tropicamide
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Trospium
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Tryptophan
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Tucatinib
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Umeclidinium
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Venlafaxine
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Verapamil
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Vilazodone
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Vonoprazan
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Voriconazole
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Vortioxetine
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Voxelotor
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Xipamide
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Zaleplon
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Ziprasidone
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Zolmitriptan
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Zolpidem
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Zopiclone
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Zotepine
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Zuranolone
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Acute pancreatitis (swelling of the pancreas) or
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Addison's disease (adrenal gland problem) or
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Alcohol use disorder, or history of or
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Drug dependence, especially opioid use disorder or dependence, or history of or
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Enlarged prostate (eg, BPH, prostatic hypertrophy) or
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Gallbladder disease or
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Increased pressure in the head or
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Lung or breathing problems (eg, COPD) or
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Problems with passing urine or
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Thyroid disease—Use with caution. May make these conditions worse.
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Asthma, acute or severe or
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Stomach or bowel blockage (eg, paralytic ileus), known or suspected or
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Respiratory depression (very slow breathing)—Should not be used in patients with these conditions.
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Brain tumor or
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Head injuries or
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Increased pressure in the head or
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Stomach problems, acute—Some of the side effects of hydrocodone can cause serious problems in people who have these conditions.
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Kidney disease, severe or
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Liver disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Portions of this document last updated: Oct. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.