Proper Use

Drug information provided by: IBM Micromedex

A nurse or other trained health professional will give you this medicine. It is given as a shot under your skin, usually in the stomach, thighs, upper arm, or buttocks. You or your caregiver may be trained to prepare and inject this medicine at home. Be sure that you understand how to use the medicine.

If you use this medicine at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject into skin areas that are tender, red, bruised, or hard.

This medicine comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

This medicine is available in two forms: a prefilled syringe or a prefilled pen, which you can use at home.

Check the liquid in the prefilled syringe. It should be clear and colorless to slightly yellow or slightly brown. Do not use it if it is cloudy, discolored, or has particles in it. Do not shake.

Allow the medicine to warm to room temperature for at least 30 minutes before you use it. Do not warm it in any other way.

Do not remove the needle cap from the prefilled syringe until you are ready to use it.

You might not use all of the medicine in each prefilled syringe or pen. Use each prefilled syringe and pen only one time. Do not save an open syringe or pen.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (solution):
    • For episodic cluster headaches:
      • Adults—At first, 300 milligrams (mg) injected under the skin (given as three 100 mg injections in a row) at the start of a cluster headache. Then 300 mg injected under the skin once a month until the end of the cluster period.
      • Children—Use and dose must be determined by your doctor.
    • For migraine headaches:
      • Adults—At first, 240 milligrams (mg) injected under the skin as a loading dose (given as two 120 mg injections in a row). This is followed by 120 mg injected under the skin once a month.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Continue to use this medicine each month from the date of your last dose. If you have missed a dose of this medicine and you are using it for episodic cluster headaches, continue to use this medicine each month from the date of your last dose until the end of the cluster period.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Keep the medicine in its original carton. You may also store it at room temperature for up to 7 days. Do not place it back in the refrigerator once you store it at room temperature.

Throw away used needles in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.