Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Prohance

Descriptions


Gadoteridol injection is a magnetic resonance imaging (MRI) contrast agent used to help create a clear picture of the body during an MRI scan. MRI scans use magnets and computers to create images or “pictures” of certain areas of the body. Unlike x-rays, MRI scans do not involve radiation. Gadoteridol is a gadolinium-based contrast agent (GBCA) that is given by injection before an MRI to help diagnose problems in the brain, spine, head, or neck.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of gadoteridol injection in newborns to children 17 years of age. Safety and efficacy have been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of gadoteridol injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Asthma or allergies, history of or
  • Diabetes or
  • Hypertension (high blood pressure) or
  • Sickle cell anemia—Use with caution. May increase risk for side effects.
  • Kidney problems, severe, or history of or
  • Liver disease, history of or
  • Seizures (grand mal), history of—Use with caution. May cause side effects to become worse.

Proper Use

A doctor or other trained health professional will give you or your child this medicine. It is given through a needle placed into one of your veins just before you have an MRI scan.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Precautions

It is very important that your doctor check your or your child's progress while you are receiving this medicine and during the MRI scan to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor or nurse right away if you or your child have burning or itching of the skin, deep bone pain in the hips or ribs, joint stiffness, a limited range of motion in the arms and legs, muscle weakness, red or dark patches on the skin of the arms or legs, or skin swelling, hardening, or tightening within the first few days or weeks after you receive this medicine. These may be symptoms of a very serious disease called nephrogenic systemic fibrosis (NSF).

This medicine may increase your risk of having acute kidney injury (AKI). This has occurred in patients with severe kidney problems, and the risk is increased with high doses of gadoteridol.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor or nurse right away if you or your child have chest pain, cold, clammy skin, confusion, dizziness, lightheadedness, a skin rash, itching, sweating, swelling of the face, tongue, and throat, or trouble breathing after receiving the medicine.

This medicine contains a metal called gadolinium, which can stay in your body (including the brain, bones, skin, kidneys, liver, spleen) for a long time (several months to years). Talk to your doctor if you have concerns.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

  1. Absence of or decrease in body movement
  2. arm, back, or jaw pain
  3. bluish color of the fingernails, lips, skin, palms, or nail beds
  4. blurred vision
  5. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  6. chest pain, discomfort, or tightness
  7. confusion
  8. cough
  9. decreased awareness or responsiveness
  10. difficult or labored breathing
  11. difficulty swallowing
  12. dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  13. false feeling of insects crawling on the skin
  14. fast, irregular, pounding, or racing heartbeat or pulse
  15. feeling of warmth
  16. fever
  17. general feeling of discomfort or illness
  18. headache, severe and throbbing
  19. hives, itching, skin rash
  20. hoarseness
  21. increased salivation
  22. loss of bladder control
  23. loss of consciousness
  24. low blood pressure or pulse
  25. nausea
  26. nervousness
  27. pounding in the ears
  28. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  29. redness of the face, neck, arms, and occasionally, upper chest
  30. seizures
  31. shakiness in the legs, arms, hands, or feet
  32. slow, fast, or irregular breathing
  33. spasm of the throat
  34. sweating
  35. trembling or shaking of the hands or feet
  36. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence not known

  1. Agitation
  2. burning, dry, or itching eyes
  3. coughing that sometimes produces a pink frothy sputum
  4. decreased or uncontrolled urination
  5. difficult, fast, noisy breathing
  6. discharge, excessive tearing
  7. incoordination
  8. lack or loss of strength
  9. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  10. muscle weakness
  11. numbness, tingling, pain, or weakness in the hands or feet
  12. paralysis or severe weakness of the legs
  13. slow heartbeat
  14. skin lesions (plaques)
  15. stiffness of the arms or legs
  16. swelling in the legs and ankles
  17. uncontrolled bowel movements
  18. uncontrolled movements of the body

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  1. Anxiety
  2. bad, unusual, or unpleasant (after) taste
  3. bleeding gums
  4. bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  5. continuing ringing or buzzing or other unexplained noise in the ears
  6. diarrhea
  7. dry mouth
  8. ear discomfort
  9. hearing loss
  10. irritation in the mouth
  11. loss of coordination in the arms
  12. mouth ulcers
  13. rash with flat lesions or small raised lesions on the skin
  14. redness and swelling of the gums
  15. runny or stuffy nose
  16. sneezing
  17. stomach cramps
  18. tingling sensation in the throat
  19. voice changes
  20. vomiting
  21. watery eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.