Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Ethiodol
  2. Lipiodol3

Descriptions


Ethiodized oil injection is used to help diagnose or find problems in the uterus, fallopian tubes, lymphatic vessels, and for looking at tumors in adults with liver cancer. It is an oil-based radiopaque contrast agent. Contrast agents are used to help create a clear picture of the body during different medical procedures.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Oil

Before Using

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ethiodized oil injection for lymphography in children.

Geriatric

Appropriate studies on the relationship of age to the effects of ethiodized oil injection have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this diagnostic test with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Metformin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to iodinated contrast agents or
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Bleeding, recent or
  • Hyperthyroidism (overactive thyroid) or
  • Trauma—Should not be used in patients with these conditions.
  • Cancer, advanced or
  • Heart problems (eg, cardiac shunt) or
  • Lung or breathing problems, advanced or
  • Radiation treatment or
  • Surgery, recent—Patients with these conditions should not receive Lipiodol® for lymphography.
  • Cervix problems or
  • Menstrual period, near or after or
  • Pelvic disease or
  • Surgery (eg, conization, curettage) within 30 days—Patients with these conditions should not receive Lipiodol® for hysterosalpingography.
  • Dilated bile ducts without external drainage—Patients with this condition should not receive Lipiodol® for liver tumor imaging.
  • Heart disease or
  • Liver disease or
  • Lung disease or
  • Portal hypertension (high blood pressure in the liver portal vein) or
  • Thyroid problems—Use with caution. May make these conditions worse.

Proper Use

A doctor or other trained health professional will give you this medicine in a hospital. It is given through a needle placed within the uterus, into a lymphatic vessel, or into an artery of the liver.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

This medicine may cause pulmonary embolism (blood clots in the lungs). Tell your doctor right away if you have anxiety, chest pain, cough, dizziness or lightheadedness, fainting, fast heartbeat, sudden trouble breathing.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness after you receive this medicine.

This medicine may cause thyroid problems (eg, overactive or underactive thyroid). Check with your doctor right away if you have depressed mood, dry skin and hair, feeling cold, hair loss, hoarseness or a husky voice, muscle cramps and stiffness, nervousness, sensitivity to heat, slowed heartbeat, sweating. weight gain or loss, or unusual tiredness or weakness.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  1. Anxiety
  2. bloated stomach
  3. changes in vision
  4. chest pain or tightness
  5. cough
  6. decreased frequency or amount of urine
  7. depressed mood
  8. difficulty with swallowing
  9. dizziness or lightheadedness
  10. fainting
  11. fast heartbeat
  12. fever
  13. headache
  14. inflamed tissue from infection
  15. loss of appetite
  16. lower back or side pain
  17. muscle cramps and stiffness
  18. nausea or vomiting
  19. pain and fullness in the right upper abdomen or stomach
  20. pain, tenderness, or swelling of the foot or leg
  21. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  22. skin rash, hives, itching, or redness
  23. stomach pain
  24. sudden trouble breathing
  25. sweating
  26. swelling of the face, fingers, or lower legs
  27. trouble sleeping
  28. unusual tiredness or weakness
  29. weight gain or loss
  30. yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Delayed healing at the incision site
  2. diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Feb. 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/ethiodized-oil-injection-route/precautions/drg-20095369