Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children over the age of 2 months and has not been shown to cause different side effects or problems than it does in adults. This medicine should not be given to infants under 2 months of age unless directed by the child's doctor, because it may cause unwanted effects.

Geriatric

This medicine is intended for use in children and is not generally used in adult patients.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Astemizole
  • Bepridil
  • Cisapride
  • Colchicine
  • Dihydroergotamine
  • Dronedarone
  • Eliglustat
  • Ergotamine
  • Flibanserin
  • Fluconazole
  • Grepafloxacin
  • Levoketoconazole
  • Levomethadyl
  • Lomitapide
  • Lovastatin
  • Mesoridazine
  • Methenamine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Simvastatin
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Acalabrutinib
  • Acecainide
  • Adagrasib
  • Afatinib
  • Ajmaline
  • Alfentanil
  • Alprazolam
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Anagrelide
  • Apixaban
  • Apomorphine
  • Aprepitant
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Ascorbic Acid
  • Asenapine
  • Atazanavir
  • Atorvastatin
  • Avapritinib
  • Azimilide
  • Azithromycin
  • Bedaquiline
  • Benzhydrocodone
  • Betrixaban
  • Bosutinib
  • Bretylium
  • Brexpiprazole
  • Brigatinib
  • Buprenorphine
  • Buserelin
  • Capivasertib
  • Carbamazepine
  • Ceritinib
  • Cerivastatin
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cholera Vaccine, Live
  • Cilostazol
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clindamycin
  • Clofazimine
  • Clomipramine
  • Clothiapine
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Codeine
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Dabigatran Etexilate
  • Dabrafenib
  • Daridorexant
  • Darunavir
  • Dasatinib
  • Deflazacort
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Dibenzepin
  • Digoxin
  • Dihydrocodeine
  • Diltiazem
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Edoxaban
  • Efavirenz
  • Elacestrant
  • Elexacaftor
  • Encainide
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Eplerenone
  • Escitalopram
  • Etrasimod
  • Everolimus
  • Fedratinib
  • Felodipine
  • Fentanyl
  • Fexinidazole
  • Finerenone
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Formoterol
  • Fosaprepitant
  • Foscarnet
  • Fosnetupitant
  • Fostemsavir
  • Gatifloxacin
  • Gemifloxacin
  • Gepirone
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydrocodone
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibrutinib
  • Ibutilide
  • Ifosfamide
  • Iloperidone
  • Imipramine
  • Infigratinib
  • Inotuzumab Ozogamicin
  • Isoflurane
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Larotrectinib
  • Lefamulin
  • Lemborexant
  • Leniolisib
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Lidoflazine
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Lumacaftor
  • Lumateperone
  • Lumefantrine
  • Lurasidone
  • Lurbinectedin
  • Macimorelin
  • Mavacamten
  • Mefloquine
  • Meperidine
  • Methadone
  • Methotrexate
  • Metronidazole
  • Mifepristone
  • Mirtazapine
  • Mitapivat
  • Mobocertinib
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Naloxegol
  • Neratinib
  • Netupitant
  • Nifedipine
  • Nilotinib
  • Nirmatrelvir
  • Nirogacestat
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olaparib
  • Oliceridine
  • Omaveloxolone
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Palovarotene
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pemigatinib
  • Pentamidine
  • Pentazocine
  • Pexidartinib
  • Pimavanserin
  • Pirmenol
  • Pitavastatin
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Porfimer
  • Prajmaline
  • Pralsetinib
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Quizartinib
  • Ranolazine
  • Relugolix
  • Repotrectinib
  • Ribociclib
  • Rimegepant
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Roflumilast
  • Selpercatinib
  • Selumetinib
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Simeprevir
  • Siponimod
  • Sirolimus Protein-Bound
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sonidegib
  • Sorafenib
  • Sotalol
  • Sparsentan
  • Spiramycin
  • Sufentanil
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Tazemetostat
  • Tedisamil
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Tenofovir Alafenamide
  • Tetrabenazine
  • Tezacaftor
  • Theophylline
  • Tolvaptan
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Troleandomycin
  • Ubrogepant
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Warfarin
  • Zanubrutinib
  • Zolmitriptan
  • Zolpidem
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetohexamide
  • Aminolevulinic Acid
  • Anisindione
  • Avanafil
  • Bexarotene
  • Budesonide
  • Buspirone
  • Diazepam
  • Dicumarol
  • Methylprednisolone
  • Midazolam
  • Phenprocoumon
  • Sildenafil
  • Sirolimus
  • Tolterodine
  • Triazolam
  • Trimetrexate
  • Valproic Acid
  • Zafirlukast

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or other blood problems or
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency—Erythromycin and sulfisoxazole may increase the chance of blood problems
  • Heart disease—High doses of erythromycin and sulfisoxazole may increase the chance of side effects in patients with a history of an irregular heartbeat
  • Kidney disease or
  • Liver disease—Patients with liver or kidney disease may have an increased chance of side effects
  • Loss of hearing—High doses of erythromycin and sulfisoxazole may increase the chance for hearing loss in some patients
  • Porphyria—Erythromycin and sulfisoxazole may increase the chance of a porphyria attack

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.