Proper Use

Drug information provided by: IBM Micromedex

Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine usually comes with patient information leaflet. Read and follow the instructions carefully and make sure you understand them before taking this medicine. Ask your doctor if you have any questions.

Swallow the capsule whole. Do not open, crush, chew, or dissolve it. You may take this medicine with or without food.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of medicine that is absorbed in the body.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For ROS1-positive non-small cell lung cancer:
      • Adults—600 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor.
    • For NTRK gene fusion-positive solid tumors:
      • Adults—600 milligrams (mg) once a day.
      • Children 12 years of age and older—Dose is based on body surface area (BSA) and must be determined by your doctor:
        • BSA greater than 1.50 meter squared (m2)—600 mg once a day.
        • BSA 1.11 to 1.50 m2—500 mg once a day.
        • BSA 0.91 to 1.10 m2—400 mg once a day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If your next dose is within 12 hours, skip the missed dose and return to your regular dosing schedule.

If you vomit after taking a dose, take another dose as soon as possible.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.