Proper Use

Drug information provided by: IBM Micromedex

A nurse or other trained health professional will give you this medicine. It is given as a shot under your skin, usually in the thigh, abdomen (stomach) area, or upper arm. This medicine may also be given at home to patients who do not need to be in a hospital or clinic. You or your caregiver may be trained to prepare and inject the medicine at home. Be sure that you understand how to use the medicine.

This medicine should come with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

If you use Dupixent® at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems. Do not inject into skin areas that are tender, damaged, bruised, or scarred.

This medicine is available as a prefilled pen or syringe. Use the prefilled pen only for adults and children 12 years of age and older.

Allow the medicine to warm to room temperature for 30 or 45 minutes before using it.

Check the liquid in the prefilled syringe. It should be clear or colorless to slightly yellow. Do not use it if it is cloudy, discolored, or has particles in it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (prefilled syringe):
    • For asthma dependent on steroids or asthma with atopic dermatitis:
      • Adults and children 12 years of age and older—At first, 600 milligrams (mg) (two 300 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 300 mg every other week.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For chronic rhinosinusitis with nasal polyposis:
      • Adults—300 milligrams (mg) injected under the skin every other week.
      • Children—Use and dose must be determined by your doctor.
    • For moderate to severe asthma:
      • Adults and children 12 years of age and older—At first, 400 or 600 milligrams (mg) (two 200 or 300 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 200 or 300 mg every other week.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For moderate to severe atopic dermatitis:
      • Adults—At first, 600 milligrams (mg) (two 300 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 300 mg every other week.
      • Children 6 years of age and older weighing 60 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. At first, 600 mg (two 300 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 300 mg every other week.
      • Children 6 years of age and older weighing 30 kg to less than 60 kg—Dose is based on body weight and must be determined by your doctor. At first, 400 mg (two 200 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 200 mg every other week.
      • Children 6 years of age and older weighing 15 kg to less than 30 kg—Dose is based on body weight and must be determined by your doctor. At first, 600 mg (two 300 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 300 mg every 4 weeks.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose and it is within 7 days from the missed dose, use a dose as soon as possible and go back to your regular dosing schedule. If you miss a dose and it is more than 7 days, skip the missed dose and go back to your regular schedule (for the every other week dose schedule) or start a new schedule based on this date (for the every 4 week dose schedule).

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Protect the medicine from direct light. Keep the medicine in the original package until you are ready to use it. You may also store the prefilled syringe or pen at room temperature for up to 14 days. Use the medicine within 14 days after removing it from the refrigerator.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.