Precautions

Drug information provided by: Merative, Micromedex®

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Use an effective form of birth control during treatment and for 5 days after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use this medicine if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), ritonavir (Norvir®), medicine for depression (eg, nefazodone, Serzone®), medicine for heart rhythm problems (eg, amiodarone, disopyramide, dofetilide, flecainide, propafenone, quinidine, sotalol, Cardioquin®, Cordarone®, Norpace®, Tikosyn®), medicine for infections (eg, clarithromycin, erythromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Ery-tab®, Ketek®, Klaricid®, Nizoral®, Sporanox®, Vfend®), or a phenothiazine medicine (eg, chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®). Using these medicines together may cause serious side effects.

Check with your doctor right away if you have chest pain, swelling of your hands, ankles, or feet, trouble breathing, or weight gain. These may be symptoms of heart failure.

This medicine can cause changes in your heart rhythm, including QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if you have fast, pounding, or irregular heartbeats.

Check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause lung problems (eg, interstitial lung disease, pneumonitis, and pulmonary fibrosis). Check with your doctor right away if you have chest pain, chills, cough, fever, general feeling of discomfort or illness, thickening of bronchial secretions, or trouble breathing.

Hypokalemia (low potassium in the blood) or hypomagnesemia (low magnesium in the blood) can occur with this medicine. Check with your doctor right away if you have decreased urine, drowsiness, dry mouth, irregular heartbeat, increased thirst, loss of appetite, mood changes, muscle pain, cramps, spasms or twitching, nausea or vomiting, numbness or tingling in the hands, feet, or lips, seizures, trembling, trouble breathing, or unusual tiredness or weakness.

This medicine may increase the risk for heart attack, stroke, or other serious side effects. Talk to your doctor about whether you should continue to take this medicine.

Do not stop taking this medicine without first checking with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

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Portions of this document last updated: May 01, 2024

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