Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cyclophosphamide in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Zoster Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Adenovirus Vaccine, Live
  • Amprenavir
  • Atazanavir
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Boceprevir
  • Carbamazepine
  • Ceritinib
  • Cholera Vaccine, Live
  • Cobicistat
  • Cyclosporine
  • Darunavir
  • Dengue Tetravalent Vaccine, Live
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Ebola Zaire Vaccine, Live
  • Eslicarbazepine Acetate
  • Etanercept
  • Fexinidazole
  • Fosamprenavir
  • Fosphenytoin
  • Idarubicin
  • Indinavir
  • Influenza Virus Vaccine, Live
  • Lemborexant
  • Lopinavir
  • Nelfinavir
  • Nevirapine
  • Nilotinib
  • Pentostatin
  • Phenobarbital
  • Phenytoin
  • Poliovirus Vaccine, Live
  • Primidone
  • Ritonavir
  • Ruxolitinib
  • Saquinavir
  • Smallpox Monkeypox Vaccine, Live Non-Replicating
  • Smallpox Vaccine
  • Sparsentan
  • St John's Wort
  • Tamoxifen
  • Telaprevir
  • Tipranavir
  • Typhoid Vaccine, Live
  • Warfarin
  • Yellow Fever Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ondansetron
  • Thiotepa

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Chickenpox (including recent exposure) or
  • Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body.
  • Gout, history of or
  • Kidney stones, history of—Cyclophosphamide may increase levels of uric acid in the body, which can cause gout or kidney stones.
  • Infection—May decrease body's ability to fight infection.
  • Kidney disease—The effects of cyclophosphamide may be increased because of slower removal from the body.
  • Liver disease—The effect of cyclophosphamide may be decreased.
  • Prior removal of adrenal gland(s)—Toxic effects of cyclophosphamide may be increased, dosage adjustment may be necessary.
  • Tumor cell accumulation—Increased risk of tumor cells entering the bone marrow, due to bone marrow depression from high doses of cyclophosphamide.