Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of clonidine and chlorthalidone combination in children with use in other age groups. However, children may be more sensitive than adults to clonidine. Clonidine overdose has been reported when children accidentally took this medicine.

Geriatric

Dizziness or lightheadedness and signs of too much potassium loss may be more likely to occur in the elderly, who are more sensitive to the effects of clonidine and chlorthalidone.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acebutolol
  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Albiglutide
  • Albuterol
  • Alogliptin
  • Amitriptyline
  • Amoxapine
  • Amtolmetin Guacil
  • Arsenic Trioxide
  • Aspirin
  • Atenolol
  • Bepridil
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bromfenac
  • Bromocriptine
  • Bufexamac
  • Buprenorphine
  • Canagliflozin
  • Carteolol
  • Celecoxib
  • Celiprolol
  • Ceritinib
  • Chlorpropamide
  • Choline Salicylate
  • Clomipramine
  • Clonixin
  • Codeine
  • Crizotinib
  • Dapagliflozin
  • Desipramine
  • Deslanoside
  • Desmopressin
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitalis
  • Digitoxin
  • Digoxin
  • Dilevalol
  • Diltiazem
  • Dipyrone
  • Dofetilide
  • Dothiepin
  • Doxepin
  • Droperidol
  • Droxicam
  • Dulaglutide
  • Empagliflozin
  • Esmolol
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Exenatide
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Formoterol
  • Glimepiride
  • Glipizide
  • Glyburide
  • Ibuprofen
  • Imipramine
  • Indomethacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glulisine
  • Iobenguane I 131
  • Ketanserin
  • Ketoprofen
  • Ketorolac
  • Levobunolol
  • Levomethadyl
  • Linagliptin
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Lofepramine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Macimorelin
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Methotrexate
  • Metildigoxin
  • Metipranolol
  • Metoprolol
  • Miglitol
  • Mirtazapine
  • Morniflumate
  • Nabumetone
  • Nadolol
  • Naproxen
  • Nateglinide
  • Nebivolol
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Oxaprozin
  • Oxprenolol
  • Oxyphenbutazone
  • Parecoxib
  • Penbutolol
  • Phenylbutazone
  • Piketoprofen
  • Pindolol
  • Pioglitazone
  • Piroxicam
  • Pramlintide
  • Proglumetacin
  • Propranolol
  • Propyphenazone
  • Proquazone
  • Protriptyline
  • Repaglinide
  • Rofecoxib
  • Rosiglitazone
  • Salicylic Acid
  • Salsalate
  • Saxagliptin
  • Sitagliptin
  • Sodium Salicylate
  • Sotalol
  • Sulindac
  • Tapentadol
  • Tenoxicam
  • Tertatolol
  • Tiaprofenic Acid
  • Timolol
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Trimipramine
  • Valdecoxib
  • Verapamil
  • Vildagliptin
  • Vonoprazan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aminolevulinic Acid
  • Cyclosporine
  • Fluphenazine
  • Gossypol
  • Licorice
  • Mepivacaine
  • Naloxone
  • Warfarin
  • Yohimbine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Type 2 diabetes mellitus—This medicine may change the amount of diabetes medicine needed
  • Gout—This medicine may increase the amount of uric acid in the blood, which can lead to gout
  • Heart or blood vessel disease or
  • Lupus erythematosus (history of) or
  • Mental depression (history of) or
  • Pancreatitis (inflammation of the pancreas) or
  • Raynaud's syndrome—This medicine may make these conditions worse
  • Kidney disease—Effects of this medicine may be increased because of slower removal from the body. If kidney disease is severe, the chlorthalidone portion of this medicine may not work
  • Liver disease—If this medicine causes loss of too much water from the body, liver disease can become much worse