Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Cleocin HCl
  2. Cleocin Pediatric

Canadian Brand Name

  1. Dalacin C Palmitate

Descriptions


Clindamycin is used to treat bacterial infections. This medicine may be given to patients who had an allergic reaction to penicillin. Clindamycin will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution
  • Capsule

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clindamycin in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clindamycin in the elderly. However, elderly patients are more likely to have diarrhea, which may require caution and adjustment in the dose for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Asciminib
  • Avacopan
  • Berotralstat
  • Carbamazepine
  • Ceritinib
  • Cholera Vaccine, Live
  • Clarithromycin
  • Crizotinib
  • Daridorexant
  • Enasidenib
  • Enzalutamide
  • Erythromycin
  • Fedratinib
  • Itraconazole
  • Lanreotide
  • Lonafarnib
  • Mavacamten
  • Mavorixafor
  • Methotrexate
  • Mitotane
  • Mobocertinib
  • Nirogacestat
  • Octreotide
  • Omaveloxolone
  • Palbociclib
  • Phenobarbital
  • Primidone
  • Repotrectinib
  • Ribociclib
  • Selpercatinib
  • Sotorasib
  • Taurursodiol
  • Tocilizumab
  • Tovorafenib
  • Tucatinib
  • Vonoprazan
  • Vorasidenib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atracurium
  • Cyclosporine
  • Metocurine
  • Tubocurarine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to aspirin—Use with caution. This medicine contains a yellow dye called tartrazine, which may cause allergic reactions (including bronchial asthma) in patients with this condition.
  • Atopic syndrome or
  • Diarrhea or
  • Liver disease, severe or
  • Kidney disease or
  • Stomach or bowel problems, history of—Use with caution. May make these conditions worse.
  • Meningitis—Should not be used in patients with this condition.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Take the capsule with a full glass (8 ounces) of water. This is to prevent irritation of the esophagus (tube between the throat and stomach).

Measure the oral liquid correctly using the marked measuring spoon that comes with the package. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you have a "strep'' infection, you should keep using this medicine for at least 10 days. This is especially important in "strep" infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. If you need help in planning the best times to take your medicine, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (capsules and solution):
    • For treatment of bacterial infections:
      • Adults—150 to 300 milligrams (mg) every 6 hours. For more severe infections, 300 to 450 mg every 6 hours.
      • Children weighing 10 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 8 to 16 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 or 4 equal doses. For more severe infections, the dose is usually 16 to 25 mg per kg of body weight per day, divided into 3 or 4 equal doses.
      • Children weighing 10 kg or less—Dose is based on body weight and must be determined by your doctor. The dose is usually 37.5 milligrams (mg) or 1/2 teaspoonful 3 times a day.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is important that your doctor check your or your child's progress after treatment. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve, or if they become worse, check with your doctor.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you or your child are using this medicine.

Serious skin reactions, including toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and Stevens-Johnson syndrome can occur with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loose skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness while you or your child are receiving this medicine.

Check with your doctor right away if you have blood in the urine, change in frequency of urination, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, trouble breathing, or weakness. These may be symptoms of serious kidney problem.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

  1. Cracks in the skin
  2. loss of heat from the body
  3. red, swollen skin scaly skin

Incidence not known

  1. Black, tarry stools
  2. bleeding gums
  3. blistering, peeling, or loosening of the skin
  4. bloating
  5. blood in the urine or stools
  6. blurred vision
  7. chest pain or tightness
  8. chills
  9. clay-colored stools
  10. cloudy urine
  11. confusion
  12. cough or hoarseness
  13. dark urine
  14. decrease in the amount of urine
  15. diarrhea
  16. diarrhea, watery and severe, which may also be bloody
  17. difficulty with swallowing
  18. dizziness
  19. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  20. dry mouth
  21. fast heartbeat
  22. fever with or without chills
  23. general feeling of tiredness or weakness
  24. headache
  25. heartburn
  26. heart stops
  27. hives or welts, itching, or skin rash
  28. increased thirst
  29. itching of the vagina or genital area
  30. joint or muscle pain
  31. loss of appetite
  32. lower back or side pain
  33. nausea or vomiting
  34. no breathing
  35. no pulse or blood pressure
  36. pain during sexual intercourse
  37. pain in the lower back or side
  38. painful or difficult urination
  39. pinpoint red spots on the skin
  40. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  41. rash with flat lesions or small raised lesions on the skin
  42. red skin lesions, often with a purple center
  43. red, irritated eyes
  44. redness of the skin
  45. sore throat
  46. sores, ulcers, or white spots in the mouth or on the lips
  47. stomach cramps, pain, or tenderness
  48. swollen glands
  49. thick, white vaginal discharge with no odor or with a mild odor
  50. thirst
  51. trouble breathing
  52. unconscious
  53. unpleasant breath odor
  54. unusual bleeding or bruising
  55. unusual tiredness or weakness
  56. unusual weight loss
  57. vomiting of blood
  58. yellow eyes or skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Sept. 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/clindamycin-oral-route/precautions/drg-20110243