Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Cleocin Phosphate IV


Clindamycin injection is used to treat bacterial infections in different areas of the body. This medicine is given to patients who had an allergic reaction to penicillin.

Clindamycin belongs to the class of medicines known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clindamycin injection in children.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clindamycin injection in the elderly. However, elderly patients are more likely to have diarrhea, which may require caution and adjustment in the dose for patients receiving this medicine.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Asciminib
  • Avacopan
  • Berotralstat
  • Carbamazepine
  • Ceritinib
  • Cholera Vaccine, Live
  • Clarithromycin
  • Crizotinib
  • Daridorexant
  • Enasidenib
  • Enzalutamide
  • Erythromycin
  • Fedratinib
  • Itraconazole
  • Lanreotide
  • Mavacamten
  • Mitotane
  • Mobocertinib
  • Nirogacestat
  • Octreotide
  • Omaveloxolone
  • Palbociclib
  • Phenobarbital
  • Primidone
  • Repotrectinib
  • Ribociclib
  • Selpercatinib
  • Sotorasib
  • Taurursodiol
  • Tocilizumab
  • Tucatinib
  • Vonoprazan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atracurium
  • Metocurine
  • Tubocurarine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Atopic syndrome or
  • Diarrhea or
  • Kidney disease or
  • Liver disease, severe or
  • Stomach or bowel problems, history of—Use with caution. May make these conditions worse.

Proper Use

A nurse or other trained health professional will give you or your child this medicine in a hospital. This medicine is given as a shot into a muscle or into a vein.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.


It is important that your doctor check your or your child's progress after treatment. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you or your child stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

This medicine contains benzyl alcohol, which may cause serious reactions (eg, gasping syndrome) to newborn or premature babies. Discuss this with your doctor if you are concerned.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Serious skin reactions, including toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and Stevens-Johnson syndrome can occur with this medicine. Check with your doctor right away if you or your child have black, tarry stools, blistering, peeling, or loose skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness while you or your child are receiving this medicine.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you or your child are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:


  1. Cracks in the skin
  2. loss of heat from the body
  3. red, swollen skin
  4. scaly skin

Incidence not known

  1. Agitation
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, or loosening of the skin
  5. bloating
  6. blood in the urine or stools
  7. blurred vision
  8. chest pain or tightness
  9. chills
  10. clay-colored stools
  11. cloudy urine
  12. coma
  13. confusion
  14. cough or hoarseness
  15. dark urine
  16. decrease in the amount of urine
  17. depression
  18. diarrhea
  19. diarrhea, watery and severe, which may also be bloody
  20. difficulty with swallowing
  21. dizziness
  22. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  23. dry mouth
  24. fast heartbeat
  25. fever with or without chills
  26. general feeling of tiredness or weakness
  27. headache
  28. heart stops
  29. hives or welts, itching, or skin rash
  30. hostility
  31. increased thirst
  32. irritability
  33. itching of the vagina or genital area
  34. joint or muscle pain
  35. lethargy
  36. loss of appetite
  37. lower back or side pain
  38. muscle twitching
  39. nausea or vomiting
  40. no breathing
  41. no pulse or blood pressure
  42. pain during sexual intercourse
  43. pain in the lower back or side
  44. pain, tenderness, or swelling of the foot or leg
  45. painful or difficult urination
  46. pinpoint red spots on the skin
  47. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  48. rapid weight gain
  49. rash with flat lesions or small raised lesions on the skin
  50. red skin lesions, often with a purple center
  51. red, irritated eyes
  52. redness of the skin
  53. seizures
  54. sore throat
  55. sores, ulcers, or white spots in the mouth or on the lips
  56. stomach cramps, pain, or tenderness
  57. swelling of the face, ankles, or hands
  58. swollen glands
  59. thick, white vaginal discharge with no odor or with a mild odor
  60. thirst
  61. unconscious
  62. unpleasant breath odor
  63. unusual bleeding or bruising
  64. unusual tiredness or weakness
  65. unusual weight loss
  66. vomiting of blood
  67. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Bitter taste
  2. changes in skin color
  3. pain, lump, or irritation at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.