Description and Brand Names

Drug information provided by: IBM Micromedex


Cefoperazone injection is used to treat bacterial infections in the different parts of the body.

Cefoperazone injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the supervision of your doctor.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of cefoperazone injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefoperazone injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving cefoperazone injection.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cholera Vaccine, Live
  • Heparin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, history of or
  • Malabsorption problems (eg, cystic fibrosis) or
  • Poor nutrition status—May increase risk of having vitamin K deficiency.
  • Allergy to beta-lactam antibiotics, history of—Should not be used in patients with this condition.
  • Bleeding problems or
  • Kidney disease or
  • Stomach or bowel disease (eg, colitis), history of—Use with caution. May make these conditions worse.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine. It is given as a shot into a muscle or through a needle placed into a vein.

You should receive every dose that is prescribed to clear up your infection, even if you feel better after the first few doses. Your infection may not clear up if you stop receiving the medicine too soon.


It is very important that your doctor check your progress while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause a serious allergic reaction, called anaphylaxis. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis) can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine.

Cefoperazone injection may cause diarrhea, and in some cases it can be severe and may occur 2 months or more after you stop receiving this medicine. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

This medicine may cause bleeding problems. Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal.

Before you have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

Do not drink alcohol during treatment and after you receive this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:


  1. Black, tarry, stools
  2. bluish color of the skin
  3. chills
  4. cough
  5. dark urine
  6. difficulty in breathing or swallowing
  7. fast heartbeat
  8. fever
  9. general tiredness and weakness
  10. light-colored stools
  11. lower back or side pain
  12. nausea
  13. pain or swelling at the injection site
  14. painful or difficult urination
  15. pale skin
  16. skin itching, rash, or redness
  17. sore throat
  18. stomach cramps
  19. swelling of the face, throat, or tongue
  20. swelling of the foot or leg
  21. tenderness
  22. ulcers, sores, or white spots in the mouth
  23. unusual bleeding or bruising
  24. unusual tiredness or weakness
  25. upper right stomach pain
  26. vomiting
  27. watery or bloody diarrhea
  28. yellow eyes and skin

Incidence not known

  1. Bleeding gums
  2. bleeding under the skin
  3. blistering, peeling, loosening of the skin
  4. blood in the urine or stools
  5. clay-colored stools
  6. cold, clammy skin
  7. confusion
  8. coughing up blood
  9. dizziness
  10. fast, weak pulse
  11. headache
  12. increased menstrual flow or vaginal bleeding
  13. joint or muscle pain
  14. lightheadedness
  15. loss of appetite
  16. nosebleeds
  17. paralysis
  18. pinpoint red spots on the skin
  19. prolonged bleeding from cuts
  20. red, irritated eyes
  21. red or black, tarry stools
  22. red or dark brown urine
  23. red skin lesions, often with a purple center
  24. stomach pain
  25. sweating
  26. unpleasant breath odor
  27. vomiting of blood

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.