Carbamazepine (Intravenous Route) Side Effects

Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

Carnexiv

Descriptions

Carbamazepine injection is used as a replacement therapy for oral carbamazepine to treat adults with certain types of seizures (epilepsy). Carbamazepine works in the brain and nervous system to control seizures. This medicine is an anticonvulsant.

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of carbamazepine injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of carbamazepine injection have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of carbamazepine injection in the elderly. However, elderly patients are more likely to have hyponatremia, which may require caution.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Artemether
Atazanavir
Boceprevir
Cabotegravir
Clorgyline
Cobicistat
Daclatasvir
Darunavir
Dasabuvir
Delamanid
Delavirdine
Doravirine
Efavirenz
Elbasvir
Elvitegravir
Fostemsavir
Grazoprevir
Isavuconazonium Sulfate
Isocarboxazid
Lenacapavir
Linezolid
Lorlatinib
Lumefantrine
Lurasidone
Maraviroc
Mavacamten
Methylene Blue
Nefazodone
Nialamide
Nirmatrelvir
Ombitasvir
Ozanimod
Pacritinib
Paritaprevir
Phenelzine
Praziquantel
Procarbazine
Ranolazine
Rasagiline
Rilpivirine
Ritonavir
Safinamide
Selegiline
Telaprevir
Tenofovir Alafenamide
Toloxatone
Tranylcypromine
Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abemaciclib
Abiraterone Acetate
Abrocitinib
Acalabrutinib
Acetaminophen
Acetazolamide
Adagrasib
Adenosine
Afatinib
Alclometasone
Aldosterone
Alfentanil
Alfuzosin
Almotriptan
Alosetron
Alpelisib
Alprazolam
Amcinonide
Amineptine
Amiodarone
Amitriptyline
Amitriptylinoxide
Amlodipine
Amodiaquine
Amoxapine
Amphetamine
Amprenavir
Apixaban
Apremilast
Aprepitant
Aranidipine
Aripiprazole
Artesunate
Astemizole
Atogepant
Atorvastatin
Avacopan
Avanafil
Avapritinib
Avatrombopag
Axitinib
Beclomethasone
Bedaquiline
Belumosudil
Bendamustine
Benzhydrocodone
Benzphetamine
Bepridil
Berotralstat
Betamethasone
Betrixaban
Bictegravir
Bortezomib
Bosentan
Bosutinib
Brexpiprazole
Brigatinib
Brivaracetam
Bromocriptine
Budesonide
Buprenorphine
Bupropion
Buspirone
Butorphanol
Cabozantinib
Caffeine
Calcifediol
Cannabidiol
Capivasertib
Capmatinib
Cariprazine
Carisoprodol
Carvedilol
Celecoxib
Ceritinib
Cerivastatin
Chloroquine
Chlorpromazine
Ciclesonide
Cilnidipine
Cilostazol
Cimetidine
Cinacalcet
Ciprofloxacin
Cisapride
Cisatracurium
Citalopram
Clarithromycin
Clevidipine
Clindamycin
Clobazam
Clobetasol
Clobetasone
Clocortolone
Clofazimine
Clomipramine
Clonazepam
Clopidogrel
Clozapine
Cobimetinib
Codeine
Colchicine
Conivaptan
Copanlisib
Cortisone
Crizotinib
Cyclophosphamide
Cyclosporine
Dabigatran Etexilate
Dabrafenib
Danazol
Dantrolene
Daprodustat
Daridorexant
Darifenacin
Darolutamide
Dasatinib
Deflazacort
Desipramine
Desloratadine
Desmopressin
Desogestrel
Desonide
Desoximetasone
Desvenlafaxine
Dexamethasone
Dexlansoprazole
Dextroamphetamine
Dextromethorphan
Diazepam
Dibenzepin
Dienogest
Diflorasone
Diflucortolone
Difluprednate
Dihydrocodeine
Dihydroergotamine
Diltiazem
Docetaxel
Dofetilide
Dolasetron
Dolutegravir
Domperidone
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Dronabinol
Dronedarone
Drospirenone
Duloxetine
Duvelisib
Edoxaban
Elacestrant
Elagolix
Eletriptan
Elexacaftor
Eliglustat
Encorafenib
Entrectinib
Enzalutamide
Eplerenone
Eravacycline
Erdafitinib
Ergotamine
Erlotinib
Erythromycin
Escitalopram
Esketamine
Esomeprazole
Estetrol
Estradiol
Eszopiclone
Ethinyl Estradiol
Ethynodiol
Etonogestrel
Etravirine
Everolimus
Exemestane
Ezogabine
Fedratinib
Felodipine
Fenfluramine
Fentanyl
Fexinidazole
Fezolinetant
Finerenone
Flucloronide
Fluconazole
Fludrocortisone
Flumethasone
Flunisolide
Fluocinolone
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluoxetine
Flurandrenolide
Flurbiprofen
Fluticasone
Fluvastatin
Fluvoxamine
Fosamprenavir
Fosaprepitant
Fosnetupitant
Fosphenytoin
Fostamatinib
Fruquintinib
Futibatinib
Gefitinib
Gepirone
Gestodene
Gilteritinib
Glasdegib
Glecaprevir
Glimepiride
Glipizide
Glyburide
Granisetron
Halcinonide
Halobetasol
Halofantrine
Haloperidol
Hemin
Hydrocodone
Hydrocortisone
Hydromorphone
Hydroxyamphetamine
Hydroxychloroquine
Hydroxytryptophan
Ibrexafungerp
Ibrutinib
Ibuprofen
Idelalisib
Ifosfamide
Imatinib
Imipramine
Indinavir
Infigratinib
Iptacopan
Irbesartan
Irinotecan
Irinotecan Liposome
Isoniazid
Isradipine
Istradefylline
Itraconazole
Ivabradine
Ivacaftor
Ivosidenib
Ixabepilone
Ixazomib
Ketamine
Ketoconazole
Labetalol
Lamotrigine
Lansoprazole
Lapatinib
Larotrectinib
Lasmiditan
Ledipasvir
Lefamulin
Lemborexant
Leniolisib
Lercanidipine
Lesinurad
Letermovir
Levoketoconazole
Levomilnacipran
Levonorgestrel
Levorphanol
Lidocaine
Linagliptin
Lisdexamfetamine
Lofepramine
Lomitapide
Lonafarnib
Loperamide
Lopinavir
Loratadine
Lorcaserin
Losartan
Loteprednol
Lovastatin
Loxapine
Lumateperone
Lurbinectedin
Macimorelin
Macitentan
Manidipine
Maribavir
Medroxyprogesterone
Medrysone
Mefloquine
Melatonin
Melitracen
Meloxicam
Meperidine
Mestranol
Metaxalone
Methadone
Methamphetamine
Methotrexate
Methylprednisolone
Mexiletine
Midazolam
Midostaurin
Mifepristone
Milnacipran
Mirtazapine
Mitapivat
Mobocertinib
Mometasone
Montelukast
Moricizine
Morphine
Morphine Sulfate Liposome
Nalbuphine
Naloxegol
Nateglinide
Nelfinavir
Neratinib
Netupitant
Nevirapine
Niacinamide
Nicardipine
Nifedipine
Nilotinib
Nimodipine
Nintedanib
Nirogacestat
Nisoldipine
Nitrendipine
Nomegestrol
Norelgestromin
Norethindrone
Norgestimate
Norgestrel
Nortriptyline
Olanzapine
Olaparib
Oliceridine
Olutasidenib
Omaveloxolone
Omeprazole
Ondansetron
Opipramol
Orlistat
Osilodrostat
Osimertinib
Oxcarbazepine
Oxybutynin
Oxycodone
Oxymorphone
Paclitaxel
Palbociclib
Paliperidone
Palonosetron
Palovarotene
Pancuronium
Panobinostat
Pantoprazole
Paramethasone
Paroxetine
Pazopanib
Pemigatinib
Pentazocine
Perampanel
Pexidartinib
Phenobarbital
Phenytoin
Pibrentasvir
Pimavanserin
Pimozide
Pioglitazone
Piperaquine
Pirfenidone
Piroxicam
Pirtobrutinib
Pitavastatin
Pitolisant
Pomalidomide
Ponatinib
Ponesimod
Posaconazole
Pralsetinib
Prednicarbate
Prednisolone
Prednisone
Pretomanid
Primaquine
Primidone
Progesterone
Proguanil
Propoxyphene
Protriptyline
Pyrimethamine
Quazepam
Quetiapine
Quinidine
Quinine
Quizartinib
Rabeprazole
Ramelteon
Ranitidine
Reboxetine
Regorafenib
Relugolix
Remifentanil
Repaglinide
Repotrectinib
Ribociclib
Rifabutin
Riluzole
Rimegepant
Rimexolone
Riociguat
Ripretinib
Risperidone
Ritlecitinib
Rivaroxaban
Rocuronium
Roflumilast
Rolapitant
Romidepsin
Ropivacaine
Rosiglitazone
Ruxolitinib
Salmeterol
Samidorphan
Saquinavir
Saxagliptin
Schisandra sphenanthera
Segesterone
Selexipag
Selpercatinib
Selumetinib
Sertraline
Sibutramine
Sildenafil
Silodosin
Simeprevir
Simvastatin
Siponimod
Sirolimus Protein-Bound
Sofosbuvir
Sonidegib
Sotorasib
Sparsentan
Stiripentol
Sufentanil
Sunitinib
Suvorexant
Tacrine
Tacrolimus
Tadalafil
Tafenoquine
Tamoxifen
Tamsulosin
Tapentadol
Tasimelteon
Tazemetostat
Telithromycin
Temsirolimus
Tenoxicam
Tepotinib
Terfenadine
Tezacaftor
Thioridazine
Thiotepa
Tianeptine
Ticagrelor
Ticlopidine
Tipranavir
Tivozanib
Tizanidine
Tofacitinib
Tolbutamide
Tolterodine
Tolvaptan
Topiramate
Torsemide
Trabectedin
Tramadol
Trazodone
Tretinoin
Triamcinolone
Triazolam
Triclabendazole
Trimipramine
Troleandomycin
Tucatinib
Ubrogepant
Ulipristal
Upadacitinib
Valbenazine
Valproic Acid
Vandetanib
Vardenafil
Vecuronium
Velpatasvir
Vemurafenib
Venetoclax
Venlafaxine
Verapamil
Vigabatrin
Vilazodone
Vinblastine
Vincristine
Vincristine Sulfate Liposome
Vinflunine
Vinorelbine
Voclosporin
Vonoprazan
Vorapaxar
Vortioxetine
Voxelotor
Voxilaprevir
Zafirlukast
Zaleplon
Zanubrutinib
Ziprasidone
Zolpidem
Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetylcysteine
Aminophylline
Anisindione
Aripiprazole Lauroxil
Caspofungin
Dalfopristin
Dicumarol
Eslicarbazepine Acetate
Etretinate
Felbamate
Flunarizine
Furosemide
Ginkgo
Hydrochlorothiazide
Influenza Virus Vaccine
Levetiracetam
Lithium
Methylphenidate
Metronidazole
Mianserin
Miokamycin
Nafimidone
Ospemifene
Phenprocoumon
Pipecuronium
Psyllium
Quinupristin
Remacemide
Rifampin
Rufinamide
Sabeluzole
Theophylline
Tiagabine
Valnoctamide
Viloxazine
Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol
Grapefruit Juice

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Black Tea

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine. Your doctor may want to have certain tests done to see if you are receiving the right amount of medicine or if certain side effects may be occurring without you knowing it. Also, the amount of medicine you are receiving may have to be changed often.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use carbamazepine together with a monoamine oxidase inhibitor (MAOI) or during the first 14 days after you stop taking a MAOI. MAOIs are used for depression and some examples are isocarboxazid (Marplan®), phenelzine (Nardil®), selegiline (Eldepryl®), or tranylcypromine (Parnate®). Do not use this medicine together with boceprevir (Victrelis®), delavirdine (Rescriptor®), and nefazodone (Serzone®).

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, a fever, or chills while you are using this medicine.

Check with your doctor right away if a fever, sore throat, rash, ulcers in the mouth, nosebleeds, bleeding gums, swollen glands, or small red or purple spots on the skin occur. These could be symptoms of a serious blood problem.

Carbamazepine may cause serious allergic reactions affecting multiple body organs (eg, liver or kidney). Check with your doctor right away if you have the following symptoms: a fever, dark urine, headache, rash, stomach pain, unusual tiredness, or yellow eyes or skin.

Carbamazepine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these unwanted effects, tell your doctor right away.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that cause drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures (eg, barbiturates), muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

This medicine may cause some people to become drowsy, dizzy, lightheaded, or less alert than they are normally, especially when they are starting treatment or increasing the dose. It may also cause blurred or double vision, weakness, or loss of muscle control in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert and well-coordinated or able to see well.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Do not stop using this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of seizures and reduce the possibility of withdrawal symptoms.

Birth control pills containing estrogen may not work properly if you take them while you are using carbamazepine. Unplanned pregnancies may occur. Use a different or additional means of birth control while you are taking carbamazepine. If you have any questions about this, check with your doctor.

Grapefruit and grapefruit juice may increase the effects of this medicine by increasing the amount in the body. You should not eat grapefruit or drink grapefruit juice while you are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Back pain
chest tightness
chills
fever
flushing
headache
nausea and vomiting
pale skin
trouble breathing
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness

Rare

Coma
confusion
convulsions
decreased urine output
dizziness
fast or irregular heartbeat
increased thirst
muscle pain or cramps
swelling of the face, ankles, or hands

Incidence not known

Bleeding gums
blistering, peeling, or loosening of the skin
blood in the urine or stools
bloody, black, or tarry stools
changes in behavior
chest pain
cough or hoarseness
dark-colored urine
decreased urine output
diarrhea
fainting
general feeling of tiredness or weakness
high fever
itching
joint or muscle pain
light-colored stools
lightheadedness
lower back or side pain
painful or difficult urination
pinpoint red spots on the skin
rapid, shallow breathing
red skin lesions, often with a purple center
red, irritated eyes
sore throat
sores, ulcers, or white spots on the lips or in the mouth
stiff neck or back
stomach pain, continuing
swelling of the face, ankles, or hands
swollen or painful glands
thoughts of killing oneself
tightness in the chest
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Sleepiness or unusual drowsiness

Less common

Double vision
seeing double

Incidence not known

Abdominal or stomach pain
burning, dry, or itching eyes
diarrhea
difficulty having a bowel movement (stool)
discharge, excessive tearing
dry mouth
loss of appetite
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
redness, swelling, or soreness of the tongue
swelling or inflammation of the mouth
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/carbamazepine-intravenous-route/side-effects/drg-20310900

Carbamazepine (Intravenous Route)

Description and Brand Names

US Brand Name

Descriptions

Before Using

Allergies

Pediatric

Geriatric

Breastfeeding

Drug Interactions

Other Interactions

Other Medical Problems

Proper Use

Precautions

Side Effects

Less common

Rare

Incidence not known

More common

Less common

Incidence not known

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