Proper Use

Drug information provided by: Merative, Micromedex®

Medicines used to treat cancer are very strong and can have many side effects. Before taking this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of unwanted effects.

This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Do not substitute Cabometyx® tablets with cabozantinib capsules. Do not substitute Cometriq® capsules with cabozantinib tablets.

Take this medicine on an empty stomach. Do not eat for at least 2 hours before and at least 1 hour after taking this medicine.

Swallow the medicine whole with a full glass (at least 8 ounces) of water. Do not crush, break, chew, or open the capsule or tablet.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may increase the amount of this medicine in the blood.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For thyroid cancer:
      • Adults—140 milligrams (mg) (one 80 mg and three 20 mg capsules) per day as a single dose. Your doctor may adjust the dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (tablets):
    • For advanced kidney cancer:
      • Adults—60 milligrams (mg) once a day. Your doctor may adjust the dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.
    • For advanced kidney cancer in combination with nivolumab:
      • Adults—40 milligrams (mg) once a day. Your doctor may adjust the dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.
    • For hepatocellular carcinoma:
      • Adults—60 milligrams (mg) once a day. Your doctor may adjust the dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.
    • For thyroid cancer:
      • Adults and children 12 years of age and older—Dose is based on body surface area (BSA) and must be determined by your doctor.
        • BSA of 1.2 meter squared (m2) or more—60 milligrams (mg) once a day. Your doctor may adjust your dose as needed and tolerated.
        • BSA of less than 1.2 m2—40 mg once a day. Your doctor may adjust your dose as needed and tolerated.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine and it is less than 12 hours until your next scheduled dose, skip the missed dose and take your next dose at the normal time. If you miss a dose and it is more than 12 hours until your next dose, take it as soon as possible and take your next dose at the normal time.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Portions of this document last updated: May 01, 2024

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