Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bupropion in the pediatric population. However, children are more sensitive to the effects of this medicine than adults when used for treating depression. Use of bupropion to treat depression in children is not recommended. Safety and efficacy of bupropion to help stop smoking have not been established in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bupropion in the elderly. However, elderly patients may be more sensitive to the effects of this medicine and are more likely to have age-related kidney or liver problems, which may require caution and an adjustment in the dose for patients receiving bupropion.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bromopride
  • Eliglustat
  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Methylene Blue
  • Moclobemide
  • Nialamide
  • Ozanimod
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Selegiline
  • Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetophenazine
  • Aclidinium
  • Acrivastine
  • Acyclovir
  • Alcaftadine
  • Alfentanil
  • Amantadine
  • Ambenonium
  • Amdinocillin
  • Amdinocillin Pivoxil
  • Amiloride
  • Amineptine
  • Aminophylline
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amphetamine
  • Amphotericin B
  • Ampicillin
  • Anisotropine
  • Antazoline
  • Aripiprazole
  • Astemizole
  • Atomoxetine
  • Atovaquone
  • Atropine
  • Azatadine
  • Azelastine
  • Azlocillin
  • Aztreonam
  • Bacampicillin
  • Baclofen
  • Balofloxacin
  • Belladonna Alkaloids
  • Benperidol
  • Benzhydrocodone
  • Benzphetamine
  • Bepotastine
  • Besifloxacin
  • Betamethasone
  • Bornaprine
  • Brexpiprazole
  • Bromodiphenhydramine
  • Bromperidol
  • Brompheniramine
  • Buclizine
  • Budesonide
  • Bupivacaine
  • Buprenorphine
  • Buspirone
  • Busulfan
  • Butorphanol
  • Butriptyline
  • Butylscopolamine
  • Carbamazepine
  • Carbenicillin
  • Carbimazole
  • Carbinoxamine
  • Carvedilol
  • Chlorambucil
  • Chloroquine
  • Chlorotrianisene
  • Chlorpheniramine
  • Chlorphenoxamine
  • Chlorpromazine
  • Chlorprothixene
  • Cimetidine
  • Cimetropium
  • Cinnarizine
  • Ciprofloxacin
  • Citalopram
  • Clemastine
  • Clemizole
  • Clidinium
  • Clobetasone
  • Clomipramine
  • Clopidogrel
  • Clothiapine
  • Clovoxamine
  • Cloxacillin
  • Clozapine
  • Cocaine
  • Codeine
  • Conjugated Estrogens
  • Corticotropin
  • Cortisone
  • Cosyntropin
  • Cyclacillin
  • Cyclizine
  • Cyclopentolate
  • Cyclosporine
  • Cyproheptadine
  • Dabrafenib
  • Dalfampridine
  • Danazol
  • Darifenacin
  • Deflazacort
  • Delavirdine
  • Demecarium
  • Desipramine
  • Desonide
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexamethasone
  • Dexbrompheniramine
  • Dexchlorpheniramine
  • Dextroamphetamine
  • Dextromethorphan
  • Dibenzepin
  • Dicloxacillin
  • Dicyclomine
  • Dienestrol
  • Diethylstilbestrol
  • Difenoxin
  • Dihydroartemisinin
  • Dihydrocodeine
  • Dimenhydrinate
  • Dimethindene
  • Diphenhydramine
  • Diphenoxylate
  • Diphenylpyraline
  • Distigmine
  • Dixyrazine
  • Donepezil
  • Dopamine
  • Dothiepin
  • Doxepin
  • Doxofylline
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxylamine
  • Droperidol
  • Duloxetine
  • Ebastine
  • Echothiophate
  • Edrophonium
  • Efavirenz
  • Emedastine
  • Enflurane
  • Enoxacin
  • Epinastine
  • Escitalopram
  • Esterified Estrogens
  • Estradiol
  • Estramustine
  • Estriol
  • Estrone
  • Estropipate
  • Ethinyl Estradiol
  • Ethopropazine
  • Etomidate
  • Famotidine
  • Femoxetine
  • Fenfluramine
  • Fentanyl
  • Fesoterodine
  • Fexinidazole
  • Flavoxate
  • Flecainide
  • Floxacillin
  • Fludrocortisone
  • Flumequine
  • Flunarizine
  • Flunisolide
  • Fluoxetine
  • Fluphenazine
  • Fluticasone
  • Fluvoxamine
  • Foscarnet
  • Fosphenytoin
  • Galantamine
  • Ganciclovir
  • Gatifloxacin
  • Glycopyrrolate
  • Guanidine
  • Halofantrine
  • Haloperidol
  • Hetacillin
  • Homatropine
  • Hydrocodone
  • Hydrocortisone
  • Hydromorphone
  • Hydroxyamphetamine
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine
  • Ifosfamide
  • Imipenem
  • Imipramine
  • Indalpine
  • Iobenguane I 123
  • Iobenguane I 131
  • Iprindole
  • Isoflurane
  • Isoflurophate
  • Isoniazid
  • Isopropamide
  • Ketamine
  • Ketotifen
  • Lemborexant
  • Levocabastine
  • Levodopa
  • Levofloxacin
  • Levomilnacipran
  • Levorphanol
  • Lidocaine
  • Lindane
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lomefloxacin
  • Lopinavir
  • Loxapine
  • Maprotiline
  • Mebeverine
  • Mebhydrolin
  • Meclizine
  • Mefenamic Acid
  • Mefloquine
  • Melitracen
  • Melperone
  • Memantine
  • Mepenzolate
  • Meperidine
  • Meropenem
  • Mesoridazine
  • Mestranol
  • Metformin
  • Methadone
  • Methamphetamine
  • Methantheline
  • Methdilazine
  • Methenolone
  • Methicillin
  • Methimazole
  • Methixene
  • Methotrimeprazine
  • Methylphenidate
  • Methylprednisolone
  • Methyltestosterone
  • Metoclopramide
  • Metopimazine
  • Metronidazole
  • Mexiletine
  • Mezlocillin
  • Midostaurin
  • Milnacipran
  • Mirtazapine
  • Mizolastine
  • Morphine
  • Moxifloxacin
  • Nadifloxacin
  • Nafcillin
  • Nalbuphine
  • Nalidixic Acid
  • Nandrolone
  • Nebivolol
  • Nefazodone
  • Neostigmine
  • Nevirapine
  • Niaprazine
  • Norfloxacin
  • Nortriptyline
  • Ofloxacin
  • Olanzapine
  • Oliceridine
  • Olopatadine
  • Ondansetron
  • Opipramol
  • Oxacillin
  • Oxaliplatin
  • Oxandrolone
  • Oxatomide
  • Oxybutynin
  • Oxycodone
  • Oxymetholone
  • Oxymorphone
  • Paramethasone
  • Paroxetine
  • Pazufloxacin
  • Pefloxacin
  • Penicillin G
  • Penicillin V
  • Pentazocine
  • Perazine
  • Periciazine
  • Perphenazine
  • Phenindamine
  • Pheniramine
  • Phenobarbital
  • Phenylpropanolamine
  • Phenyltoloxamine
  • Phenytoin
  • Physostigmine
  • Pimozide
  • Pinaverium
  • Pindolol
  • Pipamperone
  • Piperacillin
  • Piperaquine
  • Pipotiazine
  • Pirenzepine
  • Pitolisant
  • Pivampicillin
  • Pizotyline
  • Polyestradiol Phosphate
  • Prednisolone
  • Prednisone
  • Procainamide
  • Procaine
  • Prochlorperazine
  • Proguanil
  • Promazine
  • Promestriene
  • Promethazine
  • Propafenone
  • Propantheline
  • Propicillin
  • Propiverine
  • Propizepine
  • Propofol
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Prulifloxacin
  • Pyrilamine
  • Quetiapine
  • Quinacrine
  • Quinestrol
  • Ranitidine
  • Remifentanil
  • Rifampin
  • Rimexolone
  • Risperidone
  • Ritonavir
  • Rivastigmine
  • Rufloxacin
  • Safinamide
  • Scopolamine
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Solifenacin
  • Sparfloxacin
  • Sparsentan
  • Stanozolol
  • Sufentanil
  • Sulbenicillin
  • Sultamicillin
  • Sumatriptan
  • Tacrine
  • Tapentadol
  • Temocillin
  • Terfenadine
  • Testosterone
  • Theophylline
  • Thiethylperazine
  • Thiopropazate
  • Thioproperazine
  • Thioridazine
  • Thiotepa
  • Thiothixene
  • Thonzylamine
  • Tianeptine
  • Tibolone
  • Ticarcillin
  • Ticlopidine
  • Timiperone
  • Timolol
  • Tolterodine
  • Tramadol
  • Trifluoperazine
  • Triflupromazine
  • Trimeprazine
  • Trimipramine
  • Tripelennamine
  • Triprolidine
  • Tropicamide
  • Trospium
  • Umeclidinium
  • Valbenazine
  • Valethamate
  • Varenicline
  • Venlafaxine
  • Vortioxetine
  • Zidovudine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aripiprazole Lauroxil
  • Digoxin
  • Isavuconazonium Sulfate
  • Lofexidine
  • Metoprolol
  • Nirmatrelvir
  • St John's Wort
  • Tipranavir

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol use, if stopped suddenly, or
  • Eating disorders (eg, anorexia, bulimia), history of or
  • Seizures, history of or
  • Seizure medicine use, if stopped suddenly (eg, carbamazepine (Tegretol®), phenobarbital, phenytoin (Dilantin®)), or
  • Sleeping or anxiety medicine use, if stopped suddenly (eg, alprazolam (Xanax®), lorazepam (Ativan®), temazepam (Restoril®), triazolam (Halcion®))—Should not be used in patients with these conditions.
  • Arteriovenous malformation (circulation problem) or
  • Brain tumor or infection or
  • Diabetes or
  • Drug or alcohol abuse or
  • Head injury, severe or
  • Hypoglycemia (low blood sugar) or
  • Hyponatremia (low sodium in the blood) or
  • Hypoxia (low oxygen in the blood) or
  • Liver disease, severe
  • Stroke, history of—May increase the risk of seizures.
  • Bipolar disorder (type of depression), or risk of or
  • Glaucoma, angle closure or
  • Hypertension (high blood pressure) or
  • Mania or hypomania (type of mental disease), history of or
  • Psychosis (type of mental disease) or
  • Schizophrenia (type of mental disease)—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

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Portions of this document last updated: April 01, 2024

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