Proper Use

Drug information provided by: Micromedex

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Bedaquiline is given by directly observed therapy (DOT). It must always be taken with at least 3 other medicines for TB. Carefully follow your doctor's instructions.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Swallow the tablet whole with water. Do not crush, break, or chew it. Take this medicine with food.

This medicine is taken for a total of 24 weeks. On the first 2 weeks, you will take the medicine every day. On the 3rd to 24th week, you have to take it at the same time on the same 3 days (eg, Monday, Wednesday, and Friday) at least 48 hours apart each week.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For treatment of multi-drug resistant tuberculosis:
      • Adults—
        • Week 1-2: 400 milligrams (mg) (4 tablets of 100 mg) once a day with food.
        • Week 3-24: 200 mg (2 tablets of 100 mg) three times per week (with at least 48 hours between doses), for a total of 600 mg per week.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you missed a dose during the first 2 weeks, skip the missed dose and continue to use your medicine as usual. If you missed a dose during weeks 3 to 24, take the missed dose as soon as possible and then go back to your normal dosing schedule.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the medicine in its original container.