Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Do not give any medicine containing aspirin to a child with fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor . This is very important because aspirin may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.

Geriatric

People 60 years of age and older are especially sensitive to the effects of aspirin. This may increase the chance of side effects during treatment. Also, the sodium in this combination medicine can be harmful to some elderly people, especially if large amounts of the medicine are taken regularly. Therefore, it is best that older people not use this medicine for more than 5 days in a row, unless otherwise directed by their doctor.

Breastfeeding

Citric Acid

Potassium Citrate

Aspirin

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Sodium Bicarbonate

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Abrocitinib
  • Aclidinium
  • Amantadine
  • Amiloride
  • Amitriptyline
  • Amoxapine
  • Anisotropine
  • Atropine
  • Belladonna
  • Benztropine
  • Biperiden
  • Bornaprine
  • Brompheniramine
  • Butylscopolamine
  • Canrenoate
  • Canrenone
  • Carbinoxamine
  • Carisoprodol
  • Chlorpheniramine
  • Chlorpromazine
  • Cimetropium
  • Clemastine
  • Clidinium
  • Clomipramine
  • Clozapine
  • Cyclobenzaprine
  • Cyclopentolate
  • Cyproheptadine
  • Darifenacin
  • Defibrotide
  • Desipramine
  • Dichlorphenamide
  • Dicyclomine
  • Dimenhydrinate
  • Diphenhydramine
  • Doxepin
  • Emepronium
  • Eplerenone
  • Fesoterodine
  • Flavoxate
  • Fluphenazine
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Homatropine
  • Hydroxyzine
  • Hyoscyamine
  • Imipramine
  • Influenza Virus Vaccine, Live
  • Ipratropium
  • Isopropamide
  • Ketorolac
  • Loxapine
  • Mebeverine
  • Meclizine
  • Mepenzolate
  • Methantheline
  • Methixene
  • Methscopolamine
  • Nortriptyline
  • Olanzapine
  • Orphenadrine
  • Oxitropium Bromide
  • Oxybutynin
  • Paroxetine
  • Perphenazine
  • Pimozide
  • Pinaverium
  • Pipenzolate Bromide
  • Pirenzepine
  • Prochlorperazine
  • Procyclidine
  • Promethazine
  • Propantheline
  • Propiverine
  • Protriptyline
  • Quetiapine
  • Revefenacin
  • Scopolamine
  • Solifenacin
  • Spironolactone
  • Stramonium
  • Terodiline
  • Thioridazine
  • Thiothixene
  • Tiotropium
  • Tizanidine
  • Tolterodine
  • Triamterene
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimipramine
  • Tropicamide
  • Trospium
  • Umeclidinium
  • Valethamate

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acalabrutinib
  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Acetazolamide
  • Alclometasone
  • Aldosterone
  • Alipogene Tiparvovec
  • Aliskiren
  • Alteplase, Recombinant
  • Amcinonide
  • Amikacin
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amphetamine
  • Amphotericin B
  • Amtolmetin Guacil
  • Anagrelide
  • Anisindione
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Atazanavir
  • Azilsartan
  • Azilsartan Medoxomil
  • Bacitracin
  • Beclomethasone
  • Bemetizide
  • Bemiparin
  • Benazepril
  • Bendroflumethiazide
  • Benzphetamine
  • Benzthiazide
  • Betamethasone
  • Betrixaban
  • Bivalirudin
  • Brinzolamide
  • Bromfenac
  • Budesonide
  • Bufexamac
  • Bumetanide
  • Cabotegravir
  • Candesartan
  • Caplacizumab-yhdp
  • Capreomycin
  • Captopril
  • Cefuroxime Axetil
  • Celecoxib
  • Certoparin
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Choline Salicylate
  • Ciclesonide
  • Cilazapril
  • Cilostazol
  • Cisplatin
  • Citalopram
  • Clobetasol
  • Clobetasone
  • Clocortolone
  • Clomipramine
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Cortisone
  • Curcumin
  • Cyclopenthiazide
  • Cyclosporine
  • Cyclothiazide
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desonide
  • Desoximetasone
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Dextroamphetamine
  • Diazoxide
  • Dibenzepin
  • Diclofenac
  • Dicumarol
  • Diflorasone
  • Diflucortolone
  • Diflunisal
  • Difluprednate
  • Digoxin
  • Dipyrone
  • Dorzolamide
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Emtricitabine
  • Enalapril
  • Enalaprilat
  • Enoxaparin
  • Eplerenone
  • Eprosartan
  • Eptifibatide
  • Erdafitinib
  • Escitalopram
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etozolin
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Feverfew
  • Floctafenine
  • Flucloronide
  • Fludrocortisone
  • Flufenamic Acid
  • Flumethasone
  • Flunisolide
  • Fluocinolone
  • Fluocinonide
  • Fluocortin
  • Fluocortolone
  • Fluorometholone
  • Fluoxetine
  • Flurandrenolide
  • Flurbiprofen
  • Fluticasone
  • Fluvoxamine
  • Fondaparinux
  • Foscarnet
  • Fosinopril
  • Fosphenytoin
  • Furosemide
  • Gefitinib
  • Gentamicin
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Halcinonide
  • Halobetasol
  • Heparin
  • Hydrochlorothiazide
  • Hydrocortisone
  • Hydroflumethiazide
  • Ibrutinib
  • Ibuprofen
  • Imipramine
  • Indapamide
  • Indomethacin
  • Infigratinib
  • Inotersen
  • Irbesartan
  • Kanamycin
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Ledipasvir
  • Lepirudin
  • Levomilnacipran
  • Lisdexamfetamine
  • Lisinopril
  • Lithium
  • Lofepramine
  • Lornoxicam
  • Losartan
  • Loteprednol
  • Loxoprofen
  • Lumiracoxib
  • Macimorelin
  • Meclofenamate
  • Medrysone
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Melphalan
  • Memantine
  • Metformin
  • Methamphetamine
  • Methazolamide
  • Methotrexate
  • Methyclothiazide
  • Methylprednisolone
  • Metolazone
  • Milnacipran
  • Moexipril
  • Mometasone
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nateglinide
  • Nefazodone
  • Neomycin
  • Nepafenac
  • Neratinib
  • Netilmicin
  • Nicorandil
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Octreotide
  • Olmesartan
  • Opipramol
  • Oxaprozin
  • Oxyphenbutazone
  • Paramethasone
  • Parecoxib
  • Parnaparin
  • Paromomycin
  • Paroxetine
  • Pazopanib
  • Pemetrexed
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Perindopril
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Piracetam
  • Piretanide
  • Piroxicam
  • Plazomicin
  • Polythiazide
  • Potassium Citrate
  • Pranoprofen
  • Prasugrel
  • Prednicarbate
  • Prednisolone
  • Prednisone
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quinapril
  • Quinethazone
  • Ramipril
  • Repaglinide
  • Reteplase, Recombinant
  • Reviparin
  • Rilpivirine
  • Rimexolone
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Selpercatinib
  • Selumetinib
  • Sertraline
  • Sodium Salicylate
  • Sotorasib
  • Spectinomycin
  • Spirapril
  • Spironolactone
  • Streptomycin
  • Sulindac
  • Sulodexide
  • Tacrolimus
  • Telmisartan
  • Tenofovir Alafenamide
  • Tenofovir Disoproxil Fumarate
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Trandolapril
  • Trazodone
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Trichlormethiazide
  • Trimipramine
  • Turmeric
  • Valdecoxib
  • Valproic Acid
  • Valsartan
  • Vancomycin
  • Varicella Virus Vaccine, Live
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin
  • Xipamide
  • Zofenopril

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Chloroquine
  • Delapril
  • Esmolol
  • Imidapril
  • Labetalol
  • Levobunolol
  • Levothyroxine
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nitroglycerin
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Probenecid
  • Propranolol
  • Sotalol
  • Streptokinase
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Timolol

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Stomach ulcer or other stomach problems—Aspirin can make these conditions worse
  • Appendicitis (symptoms of, such as stomach or lower abdominal pain, cramping, bloating, soreness, nausea, or vomiting)—Sodium bicarbonate can make your condition worse; also, people who may have appendicitis need medical attention and should not try to treat themselves
  • Asthma, allergies, and nasal polyps (history of) or
  • Kidney disease or
  • Liver disease—The chance of serious side effects may be increased
  • Edema (swelling of face, fingers, feet, or lower legs caused by too much water in the body) or
  • Heart disease or
  • High blood pressure or
  • Toxemia of pregnancy—The sodium in this combination medicine can make these conditions worse
  • Gout—Aspirin can make this condition worse and can also keep some medicines used to treat gout from working properly
  • Hemophilia or other bleeding problems—Aspirin increases the chance of serious bleeding

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.