2020COVID-19 and related vaccine development and research

History of COVID-19: Outbreaks and vaccine timeline

Find out more about the COVID-19 pandemic, COVID-19 tests, COVID-19 treatments, mRNA research and COVID-19 vaccines.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19

The virus that causes COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19

1984

Paul A. Krieg, Ph.D., Douglas A. Melton, Ph.D., Tom Maniatis, Ph.D., and Michael Green, Ph.D. and colleagues at Harvard University use a synthesized RNA enzyme to make biologically active messenger RNA (mRNA) in a lab. A similar process is still used today to make synthetic mRNA. Drs. Krieg and Melton use synthetic mRNA to study gene function and activity. Other researchers also study RNA.

1987

Robert W. Malone, M.D., M.S. mixes mRNA with fat droplets. He discovers that when human cells are added to this mixture, they absorb the mRNA and make proteins. Dr. Malone also finds that frog embryos absorb mRNA. These experiments are considered early steps in the eventual development of mRNA-based COVID-19 vaccines.

1990s

Researchers test mRNA as a treatment in rats and as an influenza and cancer vaccine in mice.

2000s

Several researchers study mRNA treatments or vaccines. But since mRNA is easy to damage and expensive to produce, many researchers can’t get funding to pursue this work and so the research often wasn’t pursued.

2005

Katalin Kariko, Ph.D., and Drew Weissman, M.D., Ph.D., discover that modifying synthetic mRNA keeps the immune system from attacking the mRNA. This discovery moves mRNA vaccine research forward.

2010s

Many researchers study mRNA treatments or vaccines.

2019

A new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in China. The SARS-CoV-2 virus causes coronavirus disease 2019 (COVID-19). WHO will declare the COVID-19 outbreak a pandemic in 2020. WHO and CDC issue recommendations for preventing and treating COVID-19. By January 2021, COVID-19 will cause about 2.5 million deaths worldwide.

2020

Many COVID-19 vaccine clinical trials are in process. Researchers take what was previously learned from vaccine studies of SARS-CoV, MERS-CoV and other viruses to develop vaccines that prevent COVID-19. Researchers also study COVID-19 symptoms, long-term effects, diagnostic tests, antibody tests, treatments and drugs.

Mayo Clinic researchers study and develop a COVID-19 diagnostic test, an antibody test, monoclonal antibody medications, convalescent plasma therapy and vaccines.

COVID-19 vaccines

The FDA gives emergency use authorization to two mRNA COVID-19 vaccines, the Pfizer-BioNTech and the Moderna COVID-19 vaccines. Because there is an urgent need for COVID-19 vaccines and the FDA’s vaccine approval process can take months to years, the FDA first gave emergency use authorization to COVID-19 vaccines based on less data than is normally required. The data must show that the vaccines are safe and effective before the FDA can give emergency use authorization or approval. Vaccines have gone through — and continue to go through — extensive safety monitoring. Millions of COVID-19 vaccines have been given since December 2020.

Researchers at Mayo Clinic and other medical centers continue to study more vaccines that prevent COVID-19.

A young girl wearing a mask gets a COVID-19 vaccine from a health care professional wearing a mask and face shield.

COVID-19 vaccine

A child wearing a mask gets a COVID-19 vaccine.

2021

The FDA gives emergency use authorization to the Janssen/Johnson & Johnson COVID-19 vaccine. The FDA approves the Pfizer-BioNTech COVID-19 vaccine, now called Comirnaty, to prevent COVID-19 in people age 16 and older. The FDA also authorizes the Pfizer-BioNTech vaccine for children ages 5 through 15. Researchers continue to study and develop several other COVID-19 vaccines. Many COVID-19 vaccines are in clinical trials.

2022

The FDA approves the Moderna COVID-19 vaccine, now called Spikevax, to prevent COVID-19 in people age 18 and older.

  1. Plotkin SA, et al., eds. Plotkin’s Vaccines. 7th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Oct. 8, 2021.
  2. Blake JB. Benjamin Waterhouse and the introduction of vaccination. Reviews of Infectious Diseases. Oxford University Press. 1987;doi:10.1093/clinids/9.5.1044.
  3. Desmond A, et al. On the shoulders of giants — From Jenner’s cowpox to mRNA Covid vaccines. The New England Journal of Medicine. 2021; doi:10.1056/NEJMp2034334.
  4. Saleh A, et al. Vaccine development throughout history. Cureus. 2021; doi:10.7759/cureus.16635.
  5. The history of vaccines. College of Physicians of Philadelphia. https://www.historyofvaccines.org. Accessed Oct. 7, 2021.
  6. Stokes J, et al. Trivalent combined measles-mumps-rubella vaccine. JAMA. 1971;218:57.
  7. Klein NP. Licensed pertussis vaccine in the United States: History and current state. 2014; doi:10.4161/hv.29576.
  8. Influenza historic timeline. Centers for Disease Control and Prevention. https://www.cdc.gov/flu/pandemic-resources/pandemic-timeline-1930-and-beyond.htm. Accessed Oct. 7, 2021.
  9. Poland GA, et al. Development of vaccines against Zika virus. The Lancet. Infectious Diseases. 2018; doi:10.1016/S1473-3099(18)30063-X.
  10. Poland GA, et al. Zika vaccine development: Current status. Mayo Clinic Proceedings. 2019; doi:10.1016/j.mayocp.2019.05.016.
  11. Li YD, et al. Coronavirus vaccine development: From SARS and MERS to COVID-19. Journal of Biomedical Science. 2020; doi:10.1186/s12929-020-00695-2.
  12. Dolgin E. The tangled history of mRNA vaccines. Nature. 2021; doi:10.1038/d41586-021-02483-w.
  13. Goodman RA, et al., eds. Vaccination mandates: The public health imperative and individual rights. In: Law in Public Health Practice. Oxford University Press; 2007.
  14. Centers for Disease Control and Prevention. Current trends childhood immunization initiative, United States — 5-year follow up. MMWR Morbidity and Mortality Weekly Report. 1982; http://www.cdc.gov/mmwr/preview/mmwrhtml/00001091.htm. Accessed Oct. 7, 2021.
  15. Immunization and infectious diseases. HealthyPeople.gov. https://www.healthypeople.gov/2020/topics-objectives/topic/immunization-and-infectious-diseases. Accessed Oct. 7, 2021.
  16. The history of vaccines. History of the immunization schedule. College of Physicians of Philadelphia. https://www.historyofvaccines.org/content/history-immunization-schedule. Accessed Oct. 7, 2021.
  17. NNDS surveillance materials and resources. Centers for Disease Control and Prevention. https://www.cdc.gov/ncird/surveillance/materials-resources.html. Accessed Oct. 7, 2021.
  18. Roush SW, et al. Historical comparisons of morbidity and mortality for vaccine-preventable disease in the United States. JAMA. 2007;doi:10.1001/jama.298.18.2155.
  19. Poland GA (expert opinion). Mayo Clinic. Sept. 17, 2021.
  20. Vaccine effectiveness: How well do flu vaccines work? Centers for Disease Control and Prevention. https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm. Accessed Oct. 8, 2021.
  21. 1918 pandemic influenza timeline. Centers for Disease Control and Prevention. https://www.cdc.gov/flu/pandemic-resources/1918-commemoration/pandemic-timeline-1918.htm. Accessed Oct. 8, 2021.
  22. Safety of COVID-19 vaccines. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/safety-of-vaccines.html. Accessed Oct. 8, 2021.
  23. Understanding mRNA COVID-19 vaccines. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mRNA.html. Accessed Oct. 8, 2021.
  24. COVID-19 vaccines. U.S. Food and Drug Administration. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines. Accessed Oct. 12, 2021.
  25. Poland GA, et al. The age-old struggle against the antivaccinationists. The New England Journal of Medicine. 2011; doi:10.1056/NEJMp1010594.
  26. Clapesattle H. The Doctors Mayo. The University of Minnesota Press; 1941.
  27. Saint Mary’s isolation hospital during the influenza pandemic. Saint Marys Hospital Annals; 1918.
  28. Harren R. Olmsted country in the grippe of Spanish influenza. The Scribe. History Center of Olmsted Country. 2018.
  29. Strand PK. A Century of Caring: 1889-1989. Saint Marys Hospital; 1988.
  30. Mayo Clinic: The battle plan for H1N1. Mayo Alumni Magazine; 2009.
  31. First polio vaccine delivery. MayoVox. Mayo Clinic; 1955.
  32. Rosenow EC. Prophylactic inoculation against respiratory infections during the present pandemic of influenza: Preliminary report. Mayo Clinic; 1918.
  33. Rules concerning the report of contagious diseases. The Clinic Bulletin. 1919;1;1.
  34. Maltezou HA, et al. Immunization of health-care providers: Necessity and public-health policies. Healthcare. 2016; doi: 10.3390/healthcare4030047.
  35. Voigt EA, et al. Defending against smallpox: A focus on vaccines. Expert Review of Vaccines. 2016; doi:10.1080/14760584.2016.1175305.
  36. Wright GH, et al. Effect of reduced dose schedules and intramuscular injection of anthrax vaccine adsorbed on immunological response and safety profile: A randomized trial. Vaccine. 2014; doi:10.1016/j.vaccine.2013.10.039.
  37. Spikevax and Moderna COVID-19 vaccine. U.S. Food and Drug Administration. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/spikevax-and-moderna-covid-19-vaccine#additional. Accessed Feb. 11, 2022.