Publications Print Marek G. Not so subclinical: Is early thyroid disease an untapped avenue to protect children from MASLD? Hepatology. 2025 Jul 1; 82 (1):5-6 Epub 2025 June 19 View PubMed Marek G. More than a lark? LRRK2 inhibitors to treat alpha-1 antitrypsin deficiency. Hepatology. 2025 Mar 1; 81 (3):749-750 Epub 2025 Feb 17 View PubMed Marek GW, Malhi H. MetALD: Does it require a different therapeutic option? Hepatology. 2024 Dec 1; 80 (6):1424-1440 Epub 2024 May 31 View PubMed Mohammad N, Oshins R, Gu T, Clark V, Lascano J, Assarzadegan N, Marek G, Brantly M, Khodayari N. Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease. J Clin Transl Hepatol. 2024 Oct 28; 12 (10):845-856 Epub 2024 Sept 14 View PubMed Parthasarathy G, Mauer AS, Golla N, Daniel PV, Kim LH, Sidhu GS, Marek GW 3rd, Loeuillard E, Krishnan A, Lee HSK, Pavelko KD, Charlton M, Hirsova P, Ilyas SI, Malhi H. Macrophage RAGE activation is proinflammatory in NASH. JCI Insight. 2024 Feb 8; 9 (3) Epub 2024 Feb 08 View PubMed Snipes GM, Hafeez A, Marek G, Winchester DE. Sinus bradycardia with haemodynamic compromise following lithium intoxication. Drug Ther Bull. 2022 Dec; 60 (12):188-191 Epub 2022 Aug 25 View PubMed Snipes GM, Hafeez A, Marek G, Winchester DE. Sinus bradycardia with haemodynamic compromise following lithium intoxication. BMJ Case Rep. 2021 May 13; 14 (5) View PubMed Marek G, Collinsworth A, Liu C, Brantly M, Clark V. Quantitative measurement of the histological features of alpha-1 antitrypsin deficiency-associated liver disease in biopsy specimens. PLoS One. 2021; 16 (8):e0256117 Epub 2021 Aug 16 View PubMed Khodayari N, Oshins R, Holliday LS, Clark V, Xiao Q, Marek G, Mehrad B, Brantly M. Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo. Cell Commun Signal. 2020 Sep 4; 18 (1):140 Epub 2020 Sept 04 View PubMed Wang L, Marek GW 3rd, Hlady RA, Wagner RT, Zhao X, Clark VC, Fan AX, Liu C, Brantly M, Robertson KD. Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity. Hepatology. 2019 Jul; 70(1):51-66. Epub 2019 Mar 20. View PubMed Clark VC, Marek G, Liu C, Collinsworth A, Shuster J, Kurtz T, Nolte J, Brantly M. Clinical and histologic features of adults with alpha-1 antitrypsin deficiency in a non-cirrhotic cohort. J Hepatol. 2018 Dec; 69 (6):1357-1364 Epub 2018 Aug 21 View PubMed Bryant AJ, Shenoy V, Fu C, Marek G, Lorentsen KJ, Herzog EL, Brantly ML, Avram D, Scott EW. Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 Feb; 58 (2):170-180 View PubMed Khodayari N, Marek G, Lu Y, Krotova K, Wang RL, Brantly M. Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation. J Cell Biochem. 2017 Oct; 118 (10):3090-3101 Epub 2017 June 20 View PubMed Krotova K, Marek GW, Wang RL, Aslanidi G, Hoffman BE, Khodayari N, Rouhani FN, Brantly ML. Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity. Am J Respir Cell Mol Biol. 2017 Aug; 57 (2):238-247 View PubMed Khodayari N, Wang RL, Marek G, Krotova K, Kirst M, Liu C, Rouhani F, Brantly M. SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78. PLoS One. 2017; 12 (3):e0172983 Epub 2017 Mar 16 View PubMed Marek G, Pannu V, Shanmugham P, Pancione B, Mascia D, Crosson S, Ishimoto T, Sautin YY. Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway. Diabetes. 2015 Feb; 64 (2):508-18 Epub 2014 Sept 03 View PubMed Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem. 2012 Nov 23; 287 (48):40732-44 Epub 2012 Oct 03 View PubMed Baldwin W, McRae S, Marek G, Wymer D, Pannu V, Baylis C, Johnson RJ, Sautin YY. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011 Apr; 60 (4):1258-69 Epub 2011 Feb 23 View PubMed Marek G, Carver R, Ding Y, Sathyanarayan D, Zhang X, Mou Z. A high-throughput method for isolation of salicylic acid metabolic mutants. Plant Methods. 2010 Sep 23; 6:21 Epub 2010 Sept 23 View PubMed PST-20587932 Home Publications