Clinical Trials تتوفر أدناه التجارب السريرية الحالية.74 الدراسات في Cardiovascular Diseases and Cardiac Surgery (الدراسات المفتوحة فقط). تصفية قائمة الدراسات هذه حسب الموقع، والحالة والمزيد. Angiographic and Psychosocial Evaluation of Peripartum vs. Non Peripartum Spontaneous Coronary Artery Dissection (SCAD Rochester, Minn. The purpose of this study is to determine differences in clinical and imaging presentation, in-hospital management and prognosis in peri-partum and non-peri-partum SCAD patients. Prospective Identification of Long QT Syndrome in Fetal Life Rochester, Minn. The postnatal diagnosis of Long QT Syndrome (LQTS) is suggested by a prolonged QT interval on 12 lead electrocardiogram (ECG),a positive family history and/or characteristic arrhythmias and confirmed by genetic testing. LQTS testing cannot be performed successfully before birth as fetal ECG is not possible and direct measure of the fetal QT interval by magnetocardiography is limited. Genetic testing can be performed in utero, but there is risk to the pregnancy and the fetus. Although some fetuses present with arrhythmias easily recognized as LQTS (torsade des pointes (TdP) and/or 2° atrioventricular (AV) block, this is uncommon, occurring in <25% of fetal LQTS cases. Rather, the most common presentation of fetal LQTS is sinus bradycardia, a subtle rhythm disturbance that often is unappreciated to be abnormal. Consequently, the majority of LQTS cases are unsuspected and undiagnosed during fetal life, with dire consequences. For example, maternal medications commonly used during pregnancy can prolong the fetal QT interval and may provoke lethal fetal ventricular arrhythmias. But the most significant consequence is the missed opportunity for primary prevention of life threatening ventricular arrhythmias after birth because the infant is not suspected to have LQTS before birth. The over-arching goal of the study is to overcome the barriers to prenatal detection of LQTS. The investigators plan to do so by developing an algorithm using fetal heart rate (FHR) which will discriminate fetuses with or without LQTS. Immediate Goal: The investigators propose a multicenter pre-birth observational cohort study to develop a Fetal Heart Rate (FHR)/Gestational Age (GA) algorithm from a cohort of fetuses recruited from 13 national and international centers where one parent is known by prior genetic testing to have a mutation in one of the common LQTS genes: potassium voltage-gated channel subfamily Q member 1 (KCNQ1), potassium voltage-gated channel subfamily H member 2 (KCNH2), or sodium voltage-gated channel alpha subunit 5 (SCN5A). The investigators have chosen this population because 1) These mutations are the most common genetic causes of LQTS, and 2) Offspring will have high risk of LQTS as inheritance of these LQTS gene mutations is autosomal dominant. Thus, progeny of parents with a known mutation are at high (50%) risk of having the same parental LQTS mutation. The algorithm will be developed using FHR measured serially throughout pregnancy. All offspring will undergo postnatal genetic testing for the parental mutation as the gold standard for diagnosing the presence or absence of LQTS. A Study to Analyze Association of Frequent Premature Ventricular Complex with Stroke or Transient Ischemic Attack Rochester, Minn. The purpose of this study is to verify that high Premature Ventricular Complex (PVC) burden is associated with increased risk of stroke and/or Transient Ischemic Attack (TIA), to examine outcomes such as stroke/TIA, atrial fibrillation/flutter, and all-cause mortality associated with PVCs, and to evaluate whether PVCs are associated with development of appendage dysfunction. A Study of the Effect of Myectomy on the Sudden Cardiac Death Risk in Hypertrophic Cardiomyopathy Rochester, Minn. The primary purpose/objective of this study is to determine whether myectomy as a management option for severe hypertrophic cardiomyopathy (HCM) reduces the incidence of sudden cardiac death. Predictive Role of Non-Invasive Glucose Assessment During Pregnancy Rochester, Minn. This study aims to determine the value of regular, non-invasive [glucose] LabClasp monitoring during pregnancy. A Study to Evaluate the Burden of Treatment and Illness in Advanced Heart Failure Patients Rochester, Minn. The primary purpose of this study is to identify which aspects of treatment are most prevalent and burdensome to patients with advanced heart failure. A Study of Lung Ultrasound to Assess Extravascular Lung Water Rochester, Minn. The purpose of this study is to determine if lung ultrasound surface wave elastography (LUSWE) can accurately detect changes in lung elasticity (compliance) caused by the presence of extravascular lung water (pulmonary edema). the Mayo Cardiac Sarcoid Registry Rochester, Minn., Jacksonville, Fla. Aims, purpose, or objectives: Develop a retrospective registry of patients with cardiac sarcoidosis Develop a prospective registry of patients with cardiac sarcoidosis Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry Determine risk factors for sarcoid involvement of the heart Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis Understand the complications of untreated and treated cardiac sarcoidosis A Study of Heart Muscle Elasticity Measured by Echocardiography Rochester, Minn. The purpose of this study is to evaluate the possibility of using echocardiography to measure heart muscle elasticity in clinical practice. A Study to Identify the Genetic Defect(s) in Individuals with Arrhythmogenic Bi-Leaflet Mitral Prolapse (aBiMVP) Rochester, Minn. The purpose of this study is to elucidate the genetic basis of aBiMVP in hopes of determining novel mechanisms that underlie aBiMVP pathogenesis. التصفّح دراسات سريرية السابقالصفحة السابقة توجّه للصفحة 11 توجّه للصفحة 22 توجّه للصفحة 33 توجّه للصفحة 44 توجّه للصفحة 55 التاليالصفحة التالية المتخصصون في المجالات الطبية Cardiovascular Diseases & Cardiac Surgery clinical-trials