Stages

Staging describes how far cancer has grown or spread. The stage helps your care team plan treatment. Urethral cancer uses a staging system called TNM.

The TNM system looks at the tumor, nearby lymph nodes and whether cancer has spread to distant parts of the body.

  • Ta or Tis. The tumor is limited to the inner lining of the urethra.
  • T1. The tumor has grown into tissue beneath the lining of the urethra.
  • T2. The tumor has grown into tissues next to the urethra, such as the prostate.
  • T3. The tumor has grown farther into nearby structures, such as the front wall of the vagina or the bladder neck.
  • T4. The tumor has grown into another nearby organ.
  • N0. There is no evidence of cancer in lymph nodes.
  • N1. Cancer is found in one nearby lymph node.
  • N2. Cancer is found in more than one nearby lymph node.
  • M0. There is no evidence of cancer in distant parts of the body.
  • M1. Cancer has spread to a distant part of the body.

Results from imaging tests, including CT and MRI, help your care team determine the cancer stage.

01/09/2026
  1. EAU Guidelines on Primary Urethral Carcinoma. European Association of Urology; 2026. https://uroweb.org/guidelines/primary-urethral-carcinoma. Accessed Aug. 17, 2026.
  2. Urethral cancer treatment (PDQ) — Health Professional Version. National Cancer Institute. https://www.cancer.gov/types/urethral/hp/urethral-treatment-pdq. Accessed Aug. 17, 2026.
  3. Neuville P, et al. Primary urethral carcinoma: Recommendations of the oncology committee of the French Urology Association. French Journal of Urology. 2024; doi:10.1016/j.fjurol.2024.102606.
  4. Wang B, et al. Clinical and histological predictors of treatment outcomes in primary urethral carcinoma. Urologic Oncology. 2025; doi:10.1016/j.urolonc.2025.09.003.
  5. Daniels C, et al. Rethinking urethral diverticulum: A narrative review of clinical outcomes and cancer associations. International Urogynecology Journal. 2025; doi:10.1007/s00192-025-06244-5.
  6. Sanders JJ, et al. Palliative care for patients with cancer: ASCO guideline update. Journal of Clinical Oncology. 2024; doi:10.1200/JCO.24.00542.
  7. Understanding cancer prognosis. National Cancer Institute. https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis. Accessed Aug. 17, 2026.
  8. Communication in cancer care (PDQ) — Health Professional Version. National Cancer Institute. https://www.cancer.gov/about-cancer/coping/adjusting-to-cancer/communication-hp-pdq. Accessed Aug. 17, 2026.
  9. Bladder cancer. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1417. Accessed Aug. 19, 2026.
  10. Immunotherapy. American Cancer Society. https://www.cancer.org/cancer/treatment-types/immunotherapy.html. Accessed Aug. 19, 2026.
  11. Urethral cancer. MSD Manual Professional Version. https://www.msdmanuals.com/professional/oncology/genitourinary-cancers/urethral-cancer. Accessed Aug. 20, 2026.
  12. García-Perdomo HA, et al. Urethral cancer management in contemporary practice: A review. Urologic Oncology: Seminars and Original Investigations. 2026; doi:10.1016/j.urolonc.2026.04.006.
  13. Medical review (expert opinion). Mayo Clinic. Aug 21, 2026.
  14. Daneshmand S, et al. Urethral cancer. https://www.uptodate.com/contents/search. Accessed Aug. 26, 2026.
  15. Tumor Grade. National Cancer Institute. https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-grade. Accessed Aug. 28, 2026.
  16. Chemotherapy and you: Support for people with cancer. National Cancer Institute. https://www.cancer.gov/publications/patient-education/chemo-and-you. Accessed Aug. 28, 2026.