Survival rates Survival rates for people with Li-Fraumeni syndrome vary. In one large study, the estimated age at which half the studied group of people were still alive was between 65 and 66 years of age. However, survival rates cannot predict how long any one person will live. Survival depends on factors such as whether cancer develops, what type of cancer it is, and how early it is found and treated. Regular cancer screening may improve outcomes by helping find cancer earlier. طلب تحديد موعد التشخيص والعلاجالأطباء والأقسام 28/08/2026 تبادلها عبر ارسلها على الفيس بوكارسلها في تغريدة إظهار المَراجع Evans DG, et al. Li-Fraumeni syndrome. https://www.uptodate.com/contents/search. Accessed Aug. 10, 2026. Frebourg T, et al. Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes. European Journal of Human Genetics. 2020; doi:10.1038/s41431-020-0638-4. Kratz CP, et al. Cancer screening recommendations for individuals with Li-Fraumeni syndrome. 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Baseline surveillance in Li Fraumeni syndrome using whole-body MRI: A systematic review and updated meta-analysis. European Radiology. 2025; doi: 10.1007/s00330-024-10983-2. Petry V, et al. Frequency of radiation therapy-induced malignancies in patients with Li-Fraumeni syndrome and early-stage breast cancer and the influence of radiation therapy technique. International Journal of Radiation Oncology, Biology, Physics. 2024; doi:10.1016/j.ijrobp.2024.01.204. Fortuno C, et al. Cancer risks associated with TP53 pathogenic variants: Maximum likelihood analysis of extended pedigrees for diagnosis of first cancers beyond the Li-Fraumeni syndrome spectrum. JCO Precision Oncology. 2024; doi:10.1200/PO.23.00453. Surgery to reduce the risk of breast cancer. National Cancer Institute. https://www.cancer.gov/types/breast/causes-risk-factors/prevention/preventive-breast-surgery. Accessed Aug. 10, 2026. Genetic/familial high-risk assessment: Breast, ovarian, pancreatic, and prostate. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=2&id=1545. Accessed Aug. 10, 2026. Soft tissue sarcomas. American Cancer Society. https://www.cancer.org/cancer/types/soft-tissue-sarcoma.html. Accessed Aug. 12, 2026. Osteosarcoma. American Cancer Society. https://www.cancer.org/cancer/types/osteosarcoma.html. Accessed Aug. 12, 2026. Breast cancer. American Cancer Society. https://www.cancer.org/cancer/types/breast-cancer.html. Accessed Aug. 12, 2026. Brain tumors in adults. American Cancer Society. https://www.cancer.org/cancer/types/brain-spinal-cord-tumors-adults.html. Accessed Aug. 12, 2026. About adrenal cancer. American Cancer Society. https://www.cancer.org/cancer/types/adrenal-cancer/about.html. Accessed Aug. 12, 2026. Adrenal cancer early detection, diagnosis, and staging. American Cancer Society. https://www.cancer.org/cancer/types/adrenal-cancer/detection-diagnosis-staging.html. Accessed Aug. 12, 2026. Medical review (expert opinion). Mayo Clinic. Aug. 21, 2026. Satake A. Mayo Clinic researchers capture first signs of ovarian cancer risk. Mayo Clinic. https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-researchers-capture-first-signs-of-ovarian-cancer-risk/. Accessed Aug. 14, 2026. De Andrade KC, et al. Cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic or likely pathogenic germline TP53 variants: An observational cohort study. The Lancet Oncology. 2021; doi:10.1016/ S1470-2045(21)00580-5. Li-Fraumeni syndrome FAQs. Li-Fraumeni Syndrome Association (LFSA). https://www.lfsassociation.org/family-care-provider-toolkit/. Accessed Aug. 14, 2026. Awareness of LFS is important. Li-Fraumeni Syndrome Association (LFSA). https://www.lfsassociation.org/family-care-provider-toolkit/. Accessed Aug. 14, 2026. Urban RM, et al. Mosaic Li Fraumeni syndrome not identified in germinal tissue. 2026; doi:10.1002/mgg3.70178. Clinical Genomics research. Mayo Clinic. https://www.mayoclinic.org/departments-centers/clinical-genomics/sections/research/rsc-20567374. Accessed Aug. 14, 2026. Mayo Clinic Biobank. Mayo Clinic. https://www.mayo.edu/research/centers-programs/mayo-clinic-biobank/overview. Accessed Aug. 14, 2026. Ritting ML, et al. Epithelial abnormalities in the high-risk fallopian tube of a rare TP53/BRCA2 Li-Fraumeni syndrome patient with multiple tumors. JCO Precision Oncology. 2025; doi:10.1200/PO-24-00589. Li-Fraumeni syndromeالأعراضوالأسبابالتشخيصوالعلاجSurvivalratesالأطباءوالأقسام CON-20604858 الأمراض والحالات Li-Fraumeni syndrome