الجراحة

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. Optimizing Rehabilitation Effect with Electrical Stimulation Therapy Rehab

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the dentate nucleus area for improving functional status in patients with moderate to severe residual upper-extremity motor impairment due to stroke.

    

    

2. Cerebrovascular Diseases Prospective Registry

   Rochester, Minn.

   The purpose of this study is for genetic analysis of specimens removed during cerebrovascular neurosurgery to better understand pathophysiology of cerebrovascular pathology. 

    

    

3. A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty

   Rochester, Minn.

   The purpose of this study is to determine unique genetic profile of patients requiring MUA following bilateral pTKA via genetic sequencing, to determine outcomes of patients receiving MUA in terms of KSS, implant durability, survival free of reoperation, and to define characteristics and comorbidities of patients undergoing unilateral and bilateral MUA.

4. A Study to Evaluate Awake vs. Asleep Spine Surgery

   Jacksonville, Fla.

   Patients undergoing spine lumbar surgery will be asked to perform short exams/questionnaires aimed at determining cognitive function, quality of life, health outcomes twice post surgery with a baseline performance prior to surgery.

5. MElanoma Research Lymph node prediction Implementation National_001 (MERLIN_001)

   Rochester, Minn.

   This study aims to create a registry for primary melanoma gene-signature to predict sentinel node (SN) status and determine its prognostic value for more accurate staging of SN-negative melanoma patients.

6. A Vaccine (H2NVAC) Before Surgery for the Treatment of HER2-Expressing Ductal Carcinoma In Situ

   Rochester, Minn., Jacksonville, Fla.

   This phase Ib trial studies the side effects and best dose of a vaccine called H2NVAC before surgery in treating patients with HER2 expressing ductal carcinoma in situ. H2NVAC is a vaccine designed to stimulate specialized white blood cells in hopes of increasing immune response and protecting against breast cancer.

7. Renal Intervention For Chronic Hypertension Pilot Trial Using The Verve Medical RPDTM System (RPD Pilot Trial)

   Rochester, Minn.

   The RPD Pilot trial will evaluate the safety and effectiveness of Verve Medical's RPDTM renal denervation system for hypertensive patients with uncontrolled blood pressure, despite use of two anti-hypertensive medications and lifestyle changes. The novelty of the RPDTM system relates to its placement via natural orifice into the pelvis of the kidney (bilaterally) for delivery of radiofrequency energy to ablate the nerves that pass through the outer wall of the renal pelvis, a technique referred to as renal pelvic denervation (RPD).

8. Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

   Rochester, Minn.

   The purpose of this study is to determine the impact of focused ultrasound (FUS) on the composition of the tumor extracellular microenvironment.

9. Cognitive Advancement and Recovery in VNS-Rehabilitation (CARE)

   Rochester, Minn.

   The purpose of this study is to investigate whether VNS therapy leads to any changes in the cognitive functions of individuals who have survived a stroke.

10. A Study Of Sonodynamic Therapy With SONALA-001 And Exablate 4000 Type 2.0 In Subjects With Progressive Or Recurrent Glioblastoma Multiforme (RGBM)

    Rochester, Minn.

    The purpose of this study is to characterize the safety, dose limiting toxicities (DLTs), maximum tolerated dose (MTD), maximum administered dose (MAD) and recommended phase 2 dose (RP2D) for future study after treatment with SONALA-001 in combination with MRgFUS in subjects with progressive or rGBM.

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. Optimizing Rehabilitation Effect with Electrical Stimulation Therapy Rehab

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the dentate nucleus area for improving functional status in patients with moderate to severe residual upper-extremity motor impairment due to stroke.

    

    

2. Cerebrovascular Diseases Prospective Registry

   Rochester, Minn.

   The purpose of this study is for genetic analysis of specimens removed during cerebrovascular neurosurgery to better understand pathophysiology of cerebrovascular pathology. 

    

    

3. A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty

   Rochester, Minn.

   The purpose of this study is to determine unique genetic profile of patients requiring MUA following bilateral pTKA via genetic sequencing, to determine outcomes of patients receiving MUA in terms of KSS, implant durability, survival free of reoperation, and to define characteristics and comorbidities of patients undergoing unilateral and bilateral MUA.

4. A Study to Evaluate Awake vs. Asleep Spine Surgery

   Jacksonville, Fla.

   Patients undergoing spine lumbar surgery will be asked to perform short exams/questionnaires aimed at determining cognitive function, quality of life, health outcomes twice post surgery with a baseline performance prior to surgery.

5. MElanoma Research Lymph node prediction Implementation National_001 (MERLIN_001)

   Rochester, Minn.

   This study aims to create a registry for primary melanoma gene-signature to predict sentinel node (SN) status and determine its prognostic value for more accurate staging of SN-negative melanoma patients.

6. A Vaccine (H2NVAC) Before Surgery for the Treatment of HER2-Expressing Ductal Carcinoma In Situ

   Rochester, Minn., Jacksonville, Fla.

   This phase Ib trial studies the side effects and best dose of a vaccine called H2NVAC before surgery in treating patients with HER2 expressing ductal carcinoma in situ. H2NVAC is a vaccine designed to stimulate specialized white blood cells in hopes of increasing immune response and protecting against breast cancer.

7. Renal Intervention For Chronic Hypertension Pilot Trial Using The Verve Medical RPDTM System (RPD Pilot Trial)

   Rochester, Minn.

   The RPD Pilot trial will evaluate the safety and effectiveness of Verve Medical's RPDTM renal denervation system for hypertensive patients with uncontrolled blood pressure, despite use of two anti-hypertensive medications and lifestyle changes. The novelty of the RPDTM system relates to its placement via natural orifice into the pelvis of the kidney (bilaterally) for delivery of radiofrequency energy to ablate the nerves that pass through the outer wall of the renal pelvis, a technique referred to as renal pelvic denervation (RPD).

8. Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

   Rochester, Minn.

   The purpose of this study is to determine the impact of focused ultrasound (FUS) on the composition of the tumor extracellular microenvironment.

9. A Study Of Sonodynamic Therapy With SONALA-001 And Exablate 4000 Type 2.0 In Subjects With Progressive Or Recurrent Glioblastoma Multiforme (RGBM)

   Rochester, Minn.

   The purpose of this study is to characterize the safety, dose limiting toxicities (DLTs), maximum tolerated dose (MTD), maximum administered dose (MAD) and recommended phase 2 dose (RP2D) for future study after treatment with SONALA-001 in combination with MRgFUS in subjects with progressive or rGBM.

10. Cognitive Advancement and Recovery in VNS-Rehabilitation (CARE)

    Rochester, Minn.

    The purpose of this study is to investigate whether VNS therapy leads to any changes in the cognitive functions of individuals who have survived a stroke.