البحث عن طبيب

Pedro Horna, M.D.

  1. Hematopathologist
طلب موعد

المنشورات

  1. Horna P, Weybright MJ, Ferrari M, Jungherz D, Peng Y, Akbar Z, Tudor Ilca F, Otteson GE, Seheult JN, Ortmann J, Shi M, Maciocia PM, Herling M, Pule MA, Olteanu H. Dual T-cell constant beta chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry. Blood Cancer J. 2024 Feb 29; 14 (1):34
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  2. Seheult JN, Weybright MJ, Jevremovic D, Shi M, Olteanu H, Horna P. Computational Flow Cytometry Accurately Identifies Sezary Cells Based on Simplified Aberrancy and Clonality Features. J Invest Dermatol. 2024 Jan 17 [Epub ahead of print]
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  3. Vossen C, Im R, Horna P. Iron-laden blasts in refractory acute myeloid leukemia. J Hematop. 2023 Sep; 16 (3):187-188 Epub 2023 July 29
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  4. Seheult JN, Otteson GE, Jevremovic D, Horna P, Timm MM, Yuan J, Morice WG, Olteanu H, Shi M. Establishing NK-Cell Receptor Restriction by Flow Cytometry and Detecting Potential NK-Cell Clones of Uncertain Significance. Mod Pathol. 2023 Aug; 36 (8):100255 Epub 2023 June 28
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  5. Panakkal V, Lakshman A, Shi M, Olteanu H, Horna P, Timm MM, Otteson GE, Baughn LB, Greipp PT, Gonsalves WI, Kapoor P, Gertz MA, Binder M, Buadi FK, Dispenzieri A, Rajkumar SV, Kumar SK, Jevremovic D. Utility of flow cytometry screening before MRD testing in multiple myeloma. Blood Cancer J 2023 Apr 20; 13 (1):55
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  6. Horna P, King RL, Jevremovic D, Fajgenbaum DC, Dispenzieri A. The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease. Haematologica. 2023 Jan 1; 108 (1):207-218 Epub 2023 Jan 01
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  7. Patra-Kneuer M, Chang G, Xu W, Augsberger C, Grau M, Zapukhlyak M, Ilieva K, Landgraf K, Mangelberger-Eberl D, Yousefi K, Berning P, Kurz KS, Ott G, Klener P, Khandanpour C, Horna P, Schanzer J, Steidl S, Endell J, Heitmuller C, Lenz G. Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma. Front Immunol. 2023; 14:1220558 Epub 2023 July 31
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  8. Horna P, Otteson G, Shi M, Seheult JN, Jevremovic D, Olteanu H. Improved semiautomated detection of TRBC-restricted Sezary cells unveils a spectrum of clonal cluster immunophenotypes. Blood. 2022 Dec 29; 140 (26):2852-2856
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  9. Jevremovic D, Nanaa A, Geyer SM, Timm M, Azouz H, Hengel C, Reberg A, He R, Viswanatha D, Salama ME, Shi M, Olteanu H, Horna P, Otteson G, Greipp PT, Xie Z, Alkhateeb HB, Hogan W, Litzow M, Patnaik MM, Shah M, Al-Kali A, Nguyen PL. Abnormal CD13/HLA-DR Expression Pattern on Myeloblasts Predicts Development of Myeloid Neoplasia in Patients With Clonal Cytopenia of Undetermined Significance. Am J Clin Pathol. 2022 Oct 6; 158 (4):530-536
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  10. Shi M, Timm MM, Howard MT, Jevremovic D, Yuan J, Greipp PT, Peterson JF, Roh DJ, Horna P, Olteanu H. Spurious CD34 expression in B-cell lymphoma due to nonspecific binding to PerCP-Cy5.5 fluorochrome conjugates: A rare phenomenon and a diagnostic pitfall. Cytometry B Clin Cytom 2022 Jul; 102 (4):326-328 Epub 2022 June 02
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  11. Shi M, Timm MM, Howard MT, Jevremovic D, Yuan J, Greipp PT, Peterson JF, Roh DJ, Horna P, Olteanu H. Spurious CD34 expression in B-cell lymphoma due to nonspecific binding to PerCP-Cy5.5 fluorochrome conjugates: A rare phenomenon and a diagnostic pitfall. Cytometry B Clin Cytom. 2022 Jul; 102(4):326-328. Epub 2022 Jun 02.
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  12. Horna P, Pearce KE, Ketterling RP, Shi M, Peterson JF. Recurrent Chromosomal Abnormalities in Tissues Involved by Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Am J Clin Pathol. 2022 Feb 3; 157 (2):286-292
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  13. Horna P, Otteson GE, Shi M, Jevremovic D, Yuan J, Olteanu H. Flow Cytometric Evaluation of Surface and Cytoplasmic TRBC1 Expression in the Differential Diagnosis of Immature T-Cell Proliferations. Am J Clin Pathol. 2022 Jan 6; 157 (1):64-72
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  14. Rozenova KA, Jevremovic D, Reichard KK, Nguyen P, Otteson GE, Timm MM, Horna P, Olteanu H, Shi M. CD2 and CD7 are sensitive flow cytometry screening markers for T-lineage acute leukemia(s): a study of 465 acute leukemia cases. Hum Pathol. 2021 Aug; 114:66-73 Epub 2021 May 18
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  15. Horna P, Olteanu H, Jevremovic D, Otteson GE, Corley H, Ding W, Parikh SA, Shah MV, Morice WG, Shi M. Single-Antibody Evaluation of T-Cell Receptor beta Constant Chain Monotypia by Flow Cytometry Facilitates the Diagnosis of T-Cell Large Granular Lymphocytic Leukemia. Am J Clin Pathol. 2021 Jun 17; 156 (1):139-148
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  16. Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H. Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms. Cytometry B Clin Cytom. 2021 May; 100 (3):361-369 Epub 2020 Apr 25
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  17. Horna P, Shi M, Jevremovic D, Craig FE, Comfere NI, Olteanu H. Utility of TRBC1 expression in the diagnosis of peripheral blood involvement by cutaneous T-cell lymphoma Journal of Investigative Dermatology. 2021 Apr; 141 (4):821-9.e2
  18. Horna P, Shi M, Jevremovic D, Craig FE, Comfere NI, Olteanu H. Utility of TRBC1 Expression in the Diagnosis of Peripheral Blood Involvement by Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2021 Apr; 141 (4):821-829.e2 Epub 2020 Oct 10
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  19. Pulitzer MP, Horna P, Almeida J. Sezary syndrome and mycosis fungoides: An overview, including the role of immunophenotyping. Cytometry B Clin Cytom. 2021 Mar; 100 (2):132-138 Epub 2020 June 09
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  20. Horna P, Wang SA, Wolniak KL, Psarra K, Almeida J, Illingworth AJ, Johansson U, Craig FE, Torres R. Flow cytometric evaluation of peripheral blood for suspected Sezary syndrome or mycosis fungoides: International guidelines for assay characteristics. Cytometry B Clin Cytom. 2021 Mar; 100 (2):142-155 Epub 2020 Apr 22
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  21. Illingworth A, Johansson U, Huang S, Horna P, Wang SA, Almeida J, Wolniak KL, Psarra K, Torres R, Craig FE. International guidelines for the flow cytometric evaluation of peripheral blood for suspected Sezary syndrome or mycosis fungoides: Assay development/optimization, validation, and ongoing quality monitors. Cytometry B Clin Cytom. 2021 Mar; 100 (2):156-182 Epub 2020 Oct 28
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  22. Horna P, Shi M, Olteanu H, Johansson U. Emerging Role of T-cell Receptor Constant beta Chain-1 (TRBC1) Expression in the Flow Cytometric Diagnosis of T-cell Malignancies. Int J Mol Sci. 2021 Feb 12; 22 (4)
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  23. Habermann TM, Khurana A, Lentz R, Schmitz JJ, von Bormann AG, Young JR, Hunt CH, Christofferson SN, Nowakowski GS, McCullough KB, Horna P, Wood AJ, Macon WR, Kurtin PJ, Lester SC, Stafford SL, Chamarthy U, Khan F, Ansell SM, King RL. Analysis and impact of a multidisciplinary lymphoma virtual tumor board. Leuk Lymphoma. 2020 Dec; 61 (14):3351-3359 Epub 2020 Sept 23
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  24. Shi M, Nguyen P, Timm MM, Otteson GE, Horna P, Olteanu H, Jevremovic D. Cytoplasmic Expression of CD3epsilon Heterodimers by Flow Cytometry Rapidly Distinguishes Between Mature T-Cell and Natural Killer-Cell Neoplasms. Am J Clin Pathol. 2020 Oct 13; 154 (5):683-691
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  25. Shi M, Olteanu H, Jevremovic D, He R, Viswanatha D, Corley H, Horna P. T-cell clones of uncertain significance are highly prevalent and show close resemblance to T-cell large granular lymphocytic leukemia. Implications for laboratory diagnostics. Mod Pathol. 2020 Oct; 33 (10):2046-2057 Epub 2020 May 13
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  26. Vaughan JW, Shi M, Horna P, Olteanu H. Increased CD200 expression in post-transplant lymphoproliferative disorders correlates with an increased frequency of FoxP3(+) regulatory T cells. Ann Diagn Pathol. 2020 Oct; 48:151585 Epub 2020 Aug 14
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  27. Shi M, Rech KL, Otteson GE, Horna P, Olteanu H, Pardanani A, Chen D, Jevremovic D. Prevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia: A reference laboratory experience. Ann Diagn Pathol. 2020 Feb; 44:151412 Epub 2019 Oct 18
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  28. Shi M, Jevremovic D, Otteson GE, Timm MM, Olteanu H, Horna P. Single Antibody Detection of T-Cell Receptor alphabeta Clonality by Flow Cytometry Rapidly Identifies Mature T-Cell Neoplasms and Monotypic Small CD8-Positive Subsets of Uncertain Significance. Cytometry B Clin Cytom. 2020 Jan; 98 (1):99-107 Epub 2019 Apr 11
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  29. Mirza AS, Horna P, Teer JK, Song J, Akabari R, Hussaini M, Sokol L. New Insights Into the Complex Mutational Landscape of Sezary Syndrome. Front Oncol. 2020; 10:514 Epub 2020 Apr 21
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  30. Mirza AS, Dholaria BR, Hussaini M, Mushtaq S, Horna P, Ravindran A, Kumar A, Ayala E, Kharfan-Dabaja MA, Bello C, Chavez JC, Sokol L. High-dose Therapy and Autologous Hematopoietic Cell Transplantation as Consolidation Treatment for Primary Effusion Lymphoma. Clin Lymphoma Myeloma Leuk. 2019 Sep; 19 (9):e513-e520 Epub 2019 Mar 29
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  31. Patnaik MM, Pophali PA, Lasho TL, Finke CM, Horna P, Ketterling RP, Gangat N, Mangaonkar AA, Pardanani A, Tefferi A. Clinical correlates, prognostic impact and survival outcomes in chronic myelomonocytic leukemia patients with the JAK2V617F mutation. Haematologica 2019 Jun; 104 (6):e236-e239 Epub 2019 Jan 03
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  32. Horna P, Moscinski LC, Sokol L, Shao H. Naive/memory T-cell phenotypes in leukemic cutaneous T-cell lymphoma: Putative cell of origin overlaps disease classification. Cytometry B Clin Cytom. 2019 May; 96 (3):234-241 Epub 2018 Oct 16
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  33. Pophali P, Horna P, Lasho TL, Finke CM, Ketterling RP, Gangat N, Nagorney D, Tefferi A, Patnaik MM. Splenectomy in patients with chronic myelomonocytic leukemia: Indications, histopathological findings and clinical outcomes in a single institutional series of thirty-nine patients. Am J Hematol. 2018 Nov; 93 (11):1347-1357 Epub 2018 Oct 05
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  34. Perez L, Fernandez H, Horna P, Riches M, Locke F, Field T, Powers J, Sahakian E, Villagra A, Mishra A, Betts B, Kharfan-Dabaja M, Beato F, Ochoa-Bayona L, Pidala J, Anasetti C. Phase I trial of histone deacetylase inhibitor panobinostat in addition to glucocorticoids for primary therapy of acute graft-versus-host disease. Bone Marrow Transplant. 2018 Nov; 53 (11):1434-1444 Epub 2018 Apr 18
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  35. Higgins A, Mangaonkar AA, Hefazi M, Viswanatha D, Horna P, Foran J, Gangat N. Non-internal tandem duplication (ITD), non-tyrosine kinase domain (TKD) FLT3 mutations in myeloid malignancies: A brief report of 10 patients. Leuk Res 2018 Sep; 72:1-4 Epub 2018 July 21
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  36. Ferrufino-Schmidt MC, Medeiros LJ, Liu H, Clemens MW, Hunt KK, Laurent C, Lofts J, Amin MB, Ming Chai S, Morine A, Di Napoli A, Dogan A, Parkash V, Bhagat G, Tritz D, Quesada AE, Pina-Oviedo S, Hu Q, Garcia-Gomez FJ, Jose Borrero J, Horna P, Thakral B, Narbaitz M, Hughes RC 3rd, Yang LJ, Fromm JR, Wu D, Zhang D, Sohani AR, Hunt J, Vadlamani IU, Morgan EA, Ferry JA, Szigeti R, C Tardio J, Granados R, Dertinger S, Offner FA, Pircher A, Hosry J, Young KH, Miranda RN. Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. Am J Surg Pathol. 2018 Mar; 42 (3):293-305
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  37. Markow M, Mirza AS, Perez L, Perez L, Shao H, Horna P, Anasetti C, Sokol L, Hussaini MO. Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases. Case Rep Hematol. 2018; 2018:9191582 Epub 2018 Feb 28
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  38. Horna P, Shao H, Idrees A, Glass LF, Torres-Cabala CA. Indeterminate dendritic cell neoplasm of the skin: A 2-case report and review of the literature. J Cutan Pathol. 2017 Nov; 44 (11):958-963 Epub 2017 Sept 06
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  39. Hussaini MO, Rehman A, Chavez JC, Pinilla-Ibarz J, Horna P. EBV-positive Richter's syndrome with laboratory features of Burkitt's lymphoma, in Ibrutinib-treated chronic lymphocytic leukemia. Leuk Lymphoma 2017 Jul; 58 (7):1753-1756 Epub 2016 Nov 16
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  40. Sahakian E, Chen J, Powers JJ, Chen X, Maharaj K, Deng SL, Lienlaf M, Wang HW, Cheng F, Sodre AL, Distler A, Xing L, Perez-Villarroel P, Wei S, Villagra A, Seto E, Sotomayor EM, Horna P, Pinilla-Ibarz J.. Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology [Manuscript Accepted] Journal of Leukocyte Biology.2017;
  41. Betts BC, Veerapathran A, Pidala J, Yang H, Horna P, Walton K, Cubitt CL, Gunawan S, Lawrence HR, Lawrence NJ, Sebti SM, Anasetti C. Targeting Aurora kinase A and JAK2 prevents GVHD while 1 maintaining Treg and anti-tumor CTL function Sci Transl Med.2017;9:(372):pii:eaai8269.
  42. Chavez JC, Sandoval-Sus J, Horna P, Dalia S, Bello C, Chevernick P, Sotomayor EM, Sokol L, Shah B. Lymphomatoid Granulomatosis: A Single Institution Experience and Review of the Literature Clin Lymphoma Myeloma Leuk.2016;16 Suppl:S170-4.
  43. Salem KZ, Nishihori T, Kharfan-Dabaja MA, Horna P, Alsina M. Primary plasmacytoma involving mediastinal lymph nodes: A diagnostic mimicry of primary mediastinal lymphoma. Hematol Oncol Stem Cell Ther. 2016 Mar; 9 (1):26-9 Epub 2015 July 08
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  44. Zimmerman A, Locke FL, Emole J, Rosa M, Horna P, Hoover S, Dayicioglu D. Recurrent Systemic Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphoma Presenting as a Breast Implant-Associated Lesion Cancer Control.2015;22:(3)369-73.
  45. Horna P, Kurant D, Sokol L, Sotomayor EM, Moscinski L, Glass LF. Flow Cytometric Identification of Immunophenotypically Aberrant T-cell Clusters on Skin Shave Biopsies from Patients with Mycosis Fungoides Am J Clin Pathol.2015;143:(6)785-96.
  46. Peker D, Padron E, Bennett JM, Zhang X, Horna P, Epling-Burnette PK, Lancet JE, Pinilla-Ibarz J, Moscinski L, List AF, Komrokji RS, Zhang L. Close Association of Autoimmune-Mediated Processes and Autoimmune Disorders with Chronic Myelomonocytic Leukemia: Observation from a Single Institution Acta Haematol.2015;133:(2)249-56.
  47. Dalia S, Brayer J, Horna P, Zhang H, Pinilla-Ibarz J. Transformation to Hodgkin lymphoma in chronic lymphocytic leukemia coexisting with Epstein-Barr viremia Leuk Lymphoma.2014;55:(11)2660-2.
  48. Horna P, Zhang L, Sotomayor EM, Lancet JE, Moscinski LC. Diagnostic immunophenotype of acute promyelocytic leukemia before and early during therapy with all-trans retinoic acid Am J Clin Pathol.2014;142:(4)546-52.
  49. Riaz W, Zhang L, Horna P, Sokol L. Blastic plasmacytoid dendritic cell neoplasm: update on molecular biology, diagnosis, and therapy Cancer Control.2014;21:(4)279-89.
  50. Deaver D, Horna P, Cualing H, Sokol L. Pathogenesis, diagnosis, and management of kikuchi-fujimoto disease Cancer Control.2014;21:(4)313-21.
  51. Horna P, Pantazopoulos P, Lancet JE, Moscinski LC, Zhang L. Prominent hematogone hyperplasia in BCR-ABL1-positive chronic myelogenous leukemia: mimicking recurrent B-lymphoid blast crisis Leuk Lymphoma.2014;55:(8)1952-4.
  52. Dalia SM, Horna P, Zhang L. Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature Int J Clin Exp Pathol.2014;7:(8)5636-8.
  53. Horna P, Deaver DM, Qin D, Moscinski LC, Sotomayor EM, Glass LF, Sokol L. Quantitative flow cytometric identification of aberrant T cell clusters in erythrodermic cutaneous T cell lymphoma. Implications for staging and prognosis J Clin Pathol.2014;67:(5)431-6.
  54. Holdener SL, Harrington L, Nguyen J, Horna P, Sagatys E, Shah B, Zhang L. Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy--a unique case report Int J Clin Exp Pathol.2014;7:(4)1800-4.
  55. Horna P, Hamill JR, Sokol L, Glass LF. Primary Cutaneous Plasmablastic Lymphoma in an Immunocompetent Patient J Am Acad Dermatol.2013;69:(5)e274-6.
  56. Youn JI, Kumar V, Collazo M, Nefedova Y, Condamine T, Cheng P, Villagra A, Antonia S, McCaffrey JC, Fishman M, Sarnaik A, Horna P, Sotomayor E, Gabrilovich DI. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer Nat Immunol .2013;14:(3)211-20.
  57. Cheng F, Wang H, Horna P, Wang Z, Shah B, Sahakian E, Woan KV, Villagra A, Pinilla-Ibarz J, Sebti S, Smith M, Tao J, Sotomayor EM. Stat3 inhibition augments the immunogenicity of B-cell lymphoma cells, leading to effective antitumor immunity Cancer Res.2012;72:(17)4440-8.
  58. Horna P, Olteanu H, Kroft SH, Harrington AM. Flow cytometric analysis of surface light chain expression patterns in B-cell lymphomas using monoclonal and polyclonal antibodies. Am J Clin Pathol. 2011 Dec; 136 (6):954-9
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  59. Brayer J, Cheng F, Wang H, Horna P, Vicente-Suarez I, Pinilla-Ibarz J, Sotomayor EM. Enhanced CD8 T cell cross-presentation by macrophages with targeted disruption of STAT3. Immunol Lett. 2010 Jul 8; 131: (2)126-30.
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  60. Tirado CA, Chen W, Valdez FJ, Henderson S, Doolittle J, Horna P, Garcia R, Patel S, Holdridge S, Chastain C, Collins RH. Acute myeloid leukemia (M2) with a cryptic RUNX1/RUNX1T1 t(1;21;8)(p36;q22;q22) variant. Cancer Genet Cytogenet. 2009 Aug; 193: (1)67-9.
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  61. Tirado CA, Valdez FJ, Doolittle J, Garcia R, Holdridge S, Horna P, Chastain C, Matthews E, Patel S, mayne J, Smart RL, Collins RH. Un caso de leukemia mielode agude en un paciente con una translocacion y una sola fusion AML1/ETO Acta Cancerologica (The Journal of the Cancer Institute, Lima Peru).2008;36:(1)29-32.
  62. Vicente-Suarez I, Takahashi Y, Cheng F, Horna P, Wang HW, Wang HG, Sotomayor EM. Identification of a novel negative role of flagellin in regulating IL-10 production. Eur J Immunol. 2007 Nov; 37 (11):3164-75
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  63. Horna P, Sotomayor EM. Cellular and molecular mechanisms of tumor-induced T-cell tolerance. Curr Cancer Drug Targets. 2007 Feb; 7: (1)41-53.
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  64. Horna P, Cuenca A, Cheng F, Brayer J, Wang HW, Borrello I, Levitsky H, Sotomayor EM. In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood. 2006 Apr 1; 107: (7)2871-8.
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  65. Wang H, Cheng F, Cuenca A, Horna P, Zheng Z, Bhalla K, Sotomayor EM. Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood. 2005 Feb 1; 105: (3)1135-43.
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  66. Cuenca A, Cheng F, Wang H, Brayer J, Horna P, Gu L, Bien H, Borrello IM, Levitsky HI, Sotomayor EM. Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res. 2003 Dec 15; 63: (24)9007-15.
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  67. Andia LR, Cordero RS, Horna P. Patients with Retinoblastoma in Peru. Revista Peruana de Oftalmologia (Peruvian Society of Opthamology).2002;26:(1)
  68. Horna P, Curioso WH, Guillen CA, Torres CX, Kawano JE. Knowledge, Abilities and Characteristics of the Access to the Internet by Medical Students of a Peruvian University. Annales de la Facultad de Medicina (San Marcos National University, Peru).2002;63:(1)32-39.