Lung Cancer

Clinical Trials

Below is a list of Lung Cancer clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer
OBJECTIVES: Primary - To compare overall survival (OS) in patients with stage IV or recurrent non-small cell lung cancer treated with carboplatin, paclitaxel, and bevacizumab (if appropriate) with vs without cetuximab. - To compare progression-free survival (PFS) of EGFR FISH-positive patients by institutional review.
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Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-Small Lung Cancer That Was Removed By Surgery
OBJECTIVES: Primary - Compare overall survival of patients with completely resected stage IB (tumors ≥ 4cm)-IIIA non-small cell lung cancer treated with adjuvant chemotherapy with or without bevacizumab. Secondary - Compare disease-free survival of patients treated with these regimens.
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Cisplatin and Etoposide Phosphate With or Without GDC-0449 or Cixutumumab in Treating Patients With Extensive-Stage Small Cell Lung Cancer
OBJECTIVES: Primary - To evaluate the progression-free survival of patients with extensive stage small cell lung cancer treated with cisplatin and etoposide with or without Hedgehog antagonist GDC-0449 or cixutumumab. Secondary - To evaluate the response rate in patients treated with these regimens.
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Comparison of Different Types of Surgery in Treating Patients With Stage IA Non-Small Cell Lung Cancer
OBJECTIVES: Primary - Compare the disease-free survival of patients with small (≤ 2 cm) peripheral stage IA non-small cell lung cancer undergoing lobectomy vs sublobar resection (wedge resection or segmentectomy). Secondary - Compare the overall survival of patients undergoing lobectomy vs sublobar resection.
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Genetic Epidemiology Of Lung Cancer
The purpose of the study is to compare any inherited or genetic characteristics using blood or tissue specimens collected from individuals who have been diagnosed with lung cancer with the blood or tissue of their family members.
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Gold Sodium Thiomalate in Treating Patients With Advanced Non-Small Cell Lung Cancer
OBJECTIVES: - To determine the maximum tolerated dose of gold sodium thiomalate in patients with advanced non-small cell lung cancer. - To describe the toxicities associated with this treatment. - To describe any preliminary evidence of biologic activity.
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Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Approximately 8.2 million (3.3%) of Americans ≥ 12 years of age are current smokeless tobacco (ST) users, and the prevalence of ST use has increased over the past three years. ST is increasingly being promoted as a harm reduction strategy for cigarette smoking, and two of the world's largest cigarette manufacturers have entered the ST market.
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Inositol in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia
OBJECTIVES: Primary - To compare the efficacy of inositol vs placebo in reverting bronchial dysplasia in current or former smokers. Secondary - To further define the mechanism(s) of action of pharmacological doses of inositol as a lung cancer chemopreventive agent by evaluating changes in the number of dysplastic lesions and Ki-67, caspase-3, PPAR gamma, cyclin D1, cyclin E, VEGF, EGFR, NF-kappa B, and STAT3 immunostaining in
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Minimally invasive staging of lung cancer
This study evaluates a novel, minimally invasive technique for determining whether lung cancer has spread to lymph nodes. The technique, endobronchial ultrasound, uses a very small, 5-6mm, ultrasound transducer inside the airways to view and guide a biopsy of lymph nodes in the central chest (mediastinum).
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Phase III Lucanix™ Vaccine Therapy in Advanced Non-small Cell Lung Cancer (NSCLC) Following Front-line Chemotherapy
Primary Efficacy Endpoints: - Compare the overall survival of subjects with stage III or IV non-small cell lung cancer treated with belagenpumatucel-L (Lucanix™) vs placebo. Secondary Efficacy Endpoints: - Evaluate the progression free survival (PFS) of subjects treated with Lucanix™ compared to treatment within the BSC control group.
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Pioglitazone Hydrochloride in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
OBJECTIVES: Primary - To evaluate the mechanism(s) of action of pioglitazone hydrochloride (pioglitazone) as a candidate chemopreventive agent for lung cancer by investigating the effects on Ki-67 defined in non-small cell lung cancer (NSCLC) tumor tissue.
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Safety and Efficacy of Cryoablation for Metastatic Lung Tumors
ECLIPSE is a treatment, Phase 1 multicenter, prospective, single arm study with patients serving as their own control. This study is to enroll patients who will undergo cryoablation of at least 1 metastatic pulmonary tumor that is less than or equal to 3.5
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Seneca Valley Virus-001 After Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
OBJECTIVES: Primary - To compare the progression-free survival (PFS) of patients with extensive-stage small cell lung cancer treated with Seneca Valley virus-001 (NTX-010) vs placebo. Secondary - To compare the overall survival (OS) of patients treated with NTX-010 vs placebo.
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Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer
PRIMARY OBJECTIVES: I. To determine the maximally tolerated dose (MTD) of ATM (gold sodium thiomalate) plus sirolimus. SECONDARY OBJECTIVES: I. To describe the adverse event profile associated with this treatment combination. II.
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Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer
OBJECTIVES: Primary - To determine the maximum tolerated dose (MTD) of stereotactic body radiotherapy (SBRT) in medically inoperable patients with centrally located stage I non-small cell lung cancer. (Phase I) - To determine the efficacy of SBRT when administered at the MTD in these patients.
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Surgery With or Without Internal Radiation Therapy Compared With Stereotactic Body Radiation Therapy in Treating Patients With High-Risk Stage I Non-Small Cell Lung Cancer
OBJECTIVES: Primary - To ascertain whether patients treated by stereotactic body radiation therapy (SBRT) have a 3-year overall survival (OS) rate that is no more than 10% less than patients treated with sublobar resection (SR).
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Three Different Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide
OBJECTIVES: Primary - To determine whether administering high-dose thoracic radiotherapy, 70 Gy (2 Gy once daily over 7 weeks) or 61.2 Gy (1.8 Gy once daily for 16 days followed by 1.8 Gy twice daily for 9 days), will improve median and 2-year survival compared with 45 Gy (1.5
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Validation of a Multi-gene Test for Lung Cancer Risk
Because more than 160,000 individuals die of lung cancer/year in the United States alone, it is important to use the best possible methods to determine whether increased surveillance of individuals at highest risk for lung cancer will result in reduced lung cancer mortality.
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Varenicline and Bupropion for Smoking Cessation
Cigarette smoking is the single most important preventable cause of morbidity, mortality and excess health care costs in the United States and accounts for 30% of U.S. cancer deaths. Varenicline and bupropion SR (sustained-release) are non nicotine pharmacotherapies FDA-indicated for the treatment of tobacco dependence in cigarette smokers.
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