Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of everolimus when used for SEGA brain tumors in children. However, use is not recommended in children younger than 1 year of age.

Appropriate studies have not been performed on the relationship of age to the effects of everolimus when used for kidney cancer, pancreatic cancer (PNET), and kidney or liver transplants in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of everolimus in the elderly. However, elderly patients are more likely to have unwanted side effects, which may require caution and an adjustment in the dose for patients receiving everolimus.

Pregnancy

Information about this everolimus-oral-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amprenavir
  • Atazanavir
  • Boceprevir
  • Cobicistat
  • Delavirdine
  • Fosamprenavir
  • Lopinavir
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Telaprevir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Adenovirus Vaccine Type 4, Live
  • Adenovirus Vaccine Type 7, Live
  • Amiodarone
  • Aprepitant
  • Azithromycin
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Bosutinib
  • Captopril
  • Carbamazepine
  • Carvedilol
  • Ceritinib
  • Ciprofloxacin
  • Clarithromycin
  • Conivaptan
  • Crizotinib
  • Dabrafenib
  • Darunavir
  • Diltiazem
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Enzalutamide
  • Erythromycin
  • Eslicarbazepine Acetate
  • Felodipine
  • Fluconazole
  • Fosaprepitant
  • Fosphenytoin
  • Imatinib
  • Indinavir
  • Influenza Virus Vaccine, Live
  • Itraconazole
  • Ketoconazole
  • Lomitapide
  • Measles Virus Vaccine, Live
  • Mitotane
  • Mumps Virus Vaccine, Live
  • Nefazodone
  • Nilotinib
  • Phenobarbital
  • Phenytoin
  • Piperaquine
  • Poliovirus Vaccine, Live
  • Posaconazole
  • Primidone
  • Quercetin
  • Quinidine
  • Ranolazine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Siltuximab
  • Simeprevir
  • Smallpox Vaccine
  • St John's Wort
  • Telithromycin
  • Ticagrelor
  • Tipranavir
  • Tocophersolan
  • Typhoid Vaccine
  • Varicella Virus Vaccine
  • Verapamil
  • Voriconazole
  • Yellow Fever Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clotting problems or
  • Diabetes or
  • Hepatitis B infection, history of or
  • Hyperglycemia (high sugar in the blood) or
  • Hyperlipidemia (high cholesterol in the blood) or
  • Hypertriglyceridemia (high fat in the blood) or
  • Hypoxia (low oxygen in the blood) or
  • Infection (eg, bacteria, fungus, virus) or
  • Lung or breathing problems or
  • Lymphoma (cancer of the lymph glands) or
  • Proteinuria (protein in the urine) or
  • Skin cancer—Use with caution. May make these conditions worse.
  • Glucose-galactose malabsorption (a rare genetic disorder) or
  • Heart transplant, or history of or
  • Lapp lactase deficiency (a rare genetic disorder)—Use of Zortress® is not recommended in patients with these conditions.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.