There's no specific test for Reye's syndrome. Instead, screening for Reye's syndrome usually begins with blood and urine tests as well as testing for fatty acid oxidation disorders and other metabolic disorders.
Sometimes more-invasive diagnostic tests are needed to evaluate other possible causes of liver problems and investigate any neurological abnormalities. For example:
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Spinal tap (lumbar puncture). A spinal tap can help the doctor identify or rule out other diseases with similar signs and symptoms, such as infection of the lining that surrounds the brain and spinal cord (meningitis) or inflammation or infection of the brain (encephalitis).
During a spinal tap, a needle is inserted through the lower back into a space below the end of the spinal cord. A small sample of cerebrospinal fluid is removed and sent to a lab for analysis.
Liver biopsy. A liver biopsy can help the doctor identify or rule out other conditions that may be affecting the liver.
During a liver biopsy, a needle is inserted through the skin on the upper right side of the abdomen and into the liver. A small sample of liver tissue is removed and sent to a lab for analysis.
Computerized tomography (CT) scan or magnetic resonance imaging (MRI). A head CT or MRI scan can help the doctor identify or rule out other causes of behavior changes or decreased alertness.
A CT scan uses a sophisticated imaging machine linked to a computer to produce detailed, 2-D images of the brain. An MRI scan uses a strong magnetic field and radio waves rather than X-rays to generate images of the brain.
Skin biopsy. Testing for fatty acid oxidation disorders or metabolic disorders may require a skin biopsy.
During a skin biopsy, a doctor takes a small skin sample (biopsy) for analysis in a lab. A biopsy can usually be done in a doctor's office using a local anesthetic.
- Ferri FF. Ferri's Clinical Advisor 2014: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2014. https://www.clinicalkey.com. Accessed May 25, 2014.
- Cherry JD, et al. Feigin and Cherry's Textbook of Pediatric Infectious Diseases. 7th ed. Philadelphia, Pa.: Saunders Elsevier; 2014. https://www.clinicalkey.com. Accessed May 25, 2014.
- NINDS Reye's syndrome information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/reyes_syndrome/reyes_syndrome.htm. Accessed May 25, 2014.
- What is Reye's syndrome? National Reye's Syndrome Foundation. http://www.reyessyndrome.org/what.html. Accessed May 25, 2014.
- Chiriboga CA. Acute toxic-metabolic encephalopathy in children. http://www.uptodate.com/home. Accessed May 25, 2014.
- Reye's syndrome. The Merck Manual for Health Care Professionals. http://www.merckmanuals.com/professional/pediatrics/miscellaneous_disorders_in_infants_and_children/reyes_syndrome.html. Accessed May 26, 2014.
- Medications containing aspirin (acetylsalicylate) and aspirin-like products. National Reye's Syndrome Foundation. http://www.reyessyndrome.org/. Accessed May 28, 2014.
- Renaud DL (expert opinion). Mayo Clinic, Rochester, Minn. June 2, 2014.