Bile acid resins
These drugs, such as cholestyramine (Prevalite), colestipol (Colestid) and colesevelam (Welchol), bind to bile acids in the intestine. These acids contain cholesterol, which are then eliminated from the body.
- Benefits. Bile acid resins can lower LDL cholesterol by 15 to 30 percent.
- Possible side effects. Bile acid resins may need to be taken in combination with other cholesterol-lowering drugs to effectively lower LDL levels. They may cause stomach and intestinal issues such as constipation.
Nicotinic acid (Niacin) is a water-soluble B vitamin that lowers bad cholesterol and increases good cholesterol.
- Benefits. Nicotinic acid reduces LDL levels by 5 to 15 percent, and up to 25 percent in some people.
- Possible side effects. Nicotinic acid may cause flushing, itchiness and upset stomach. Your doctor must monitor your liver function if you're taking this drug. Don't use it if you have diabetes because it can raise blood sugar levels.
Fibrates, such as gemfibrozil (Lopid) and fenofibrate (Tricor), can raise good cholesterol if you have low HDL levels.
- Benefits. Fibrates can improve HDL levels.
- Possible side effects. Among all cholesterol-lowering medications, fibrates are the least effective at lowering bad cholesterol. They can also cause muscle pain when prescribed with statins, as well as digestive problems.
Your doctor will recommend a specific choice of medication or combination of medications based on a variety of factors, such as your individual risk factors, your age, your current health and possible side effects. Your doctor will also monitor your medication regularly and recommend lifestyle changes that will allow you to take less medication and lower your risk of heart disease.
Apr. 01, 2014
See more In-depth
- Your guide to lowering your cholesterol with TLC. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/cgi-bin/search?q=TLC&site=NHLBI_Public&client=NHLBI_Public_frontend&proxystylesheet=NHLBI_Public_frontend&output=xml_no_dtd&getfields=description.keywords&oe=ISO-8859-1&ie=ISO-8859-1. Accessed Feb. 5, 2014.
- Drug therapy for cholesterol. American Heart Association. http://www.heart.org/HEARTORG/Conditions/Cholesterol/PreventionTreatmentofHighCholesterol/Drug-Therapy-for-Cholesterol_UCM_305632_Article.jsp. Accessed Feb. 5, 2014.
- Third report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Bethesda, Md.: National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/cholesterol. Accessed Feb. 6, 2014.
- Zetia (prescribing information). Whitehouse Station, N.J. Merck and Co.; 2012. http://www.zetia.com/ezetimibe/zetia/consumer/prescribing-information/index.jsp?WT.svl=1. Accessed Feb. 6, 2014.
- How is high blood cholesterol treated? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/hbc/treatment.html. Accessed Feb. 5, 2014.
- High blood cholesterol: What you need to know. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/public/heart/chol/wyntk.htm. Accessed Feb. 5, 2014.