Quality CareFind out why Mayo Clinic is the right place for your health care. Make an appointment.
Meet the StaffFind a directory of doctors and departments at all Mayo Clinic campuses. Visit now.
Research and Clinical TrialsSee how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now.
Visit Our SchoolsEducators at Mayo Clinic train tomorrow’s leaders to deliver compassionate, high-value, safe patient care. Choose a degree.
Professional ServicesExplore Mayo Clinic’s many resources and see jobs available for medical professionals. Get updates.
Give to Mayo ClinicHelp set a new world standard in care for people everywhere. Give now.
Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.
Subscribe to Housecall
Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Yes. In large amounts, calcium supplements may interact with some blood pressure medications. Interactions may occur with:
Thiazide diuretics. Taking 1,500 milligrams (mg) or more of calcium with thiazide diuretics — such as chlorothiazide (Diuril), hydrochlorothiazide (Microzide, Oretic) and indapamide — can result in milk-alkali syndrome, a serious condition.
In general, avoid taking more than 1,500 mg of calcium (supplements and food sources combined) a day if you're taking a thiazide diuretic (also referred to as water pills).
If you take calcium supplements while taking a thiazide diuretic, talk to your doctor about the appropriate dose, and have your blood pressure and calcium levels checked.
Calcium channel blockers. When given through an intravenous (IV) line, calcium may decrease the effects of calcium channel blockers, such as nifedipine (Adalat CC, Afeditab CR, Procardia), verapamil (Calan, Covera-HS, Tarka), diltiazem (Cardizem, Cartia XT, Dilacor XR, others) and others. In fact, IV calcium is used to help reverse calcium channel blocker overdose.
There's no evidence that oral calcium supplements interfere with calcium channel blockers. To be safe, check your blood pressure regularly if taking calcium channel blockers and calcium supplements at the same time.
Calcium supplements don't appear to interact with other commonly prescribed blood pressure medications, such as:
Talk to your doctor if you take high blood pressure medications and calcium supplements and are concerned about interactions.
Sheldon G. Sheps, M.D.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.
We comply with the HONcode standard for trustworthy health information: verify here.