Below are current clinical trials.5 studies in Cirrhosis
(open studies only).
Filter this list of studies by location, status and more.
A variety of liver insults lead to pathological changes in liver architecture that culminate in cirrhosis. While invasive liver biopsy was required to detect cirrhosis, the development of magnetic resonance elastography (MRE) has revolutionized our ability to detect liver fibrosis through non-invasive means that involve measurement of liver stiffness. However, a number of pathological findings occur in liver in response to various insults that precede cirrhosis and are clinically important to identify such as steatosis associated with NASH, inflammation associated with viral hepatitis, and congestion associated with cardiac hepatopathy. Detection of such entities provides essential diagnostic, prognostic, and treatment information but yet is not available non-invasively. Recent murine studies from this group of investigators has identified that MRE technology can be adapted to non-invasively detect these conditions. Implementing this into the practice will transform it by obviating the need for invasive liver biopsies in patients suspected of having such forms of suspected liver disease. This will differentiate Mayo from other institutions where such technology is not available.
An additional aim of this study is to examine the impact of obstructive sleep apnea (OSA) on the pathogenesis of nonalcoholic fatty liver disease (NAFLD), both common comorbidities of obesity. Recent evidence indicates a potential link between OSA and severity of NASH and fibrosis, but the mechanisms of OSA- associated hypoxia on liver disease progression in NAFLD is unclear. This study offers the unique opportunity to analyze this association, as the study population will undergo routine evaluation for OSA, as part as the preoperative work-up prior to bariatric surgery.
The purpose of this study is to assess the effectiveness of a new ultrasound technique for non-invasive evaluation of liver fibrosis.
The purpose of this study is to develop and validate a brief patient reported outcomes questionaire that is responsive to ascites-related symptoms in liver cirrhosis.
The purpose of this study is to evaluate the usefulness of new markers found in blood that might help to diagnose of liver cancer (HCC) early among people with cirrhosis. We hope that this study will show that these new markers could identify HCC at an earlier stage where better treatment options are available.
The purpose of the Hepatic Tissue Research Registry is to establish a local program to procure resected liver tissue and to gather critical patient and research information that will be utilized to develop a comprehensive biomedical database. This Registry data will be made accessible to scientists at Mayo, researchers outside of Mayo who have collaborations with Mayo researchers and to further biomedical and clinical research in liver biology, toxicology, cell transplantation, liver support therapy, and pathology.
April 06, 2016
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- Ferri FF. Cirrhosis. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Dec. 26, 2015.
- Cirrhosis. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/liver-disease/cirrhosis/Pages/facts.aspx. Accessed Dec. 27, 2015.
- Boyer TD, et al., eds. Hepatic fibrosis and cirrhosis. In: Zakim & Boyer's Hepatology: A Textbook of Liver Disease. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. https://www.clinicalkey.com. Accessed Dec. 26, 2015.
- Tsochatzis EA, et al. Liver cirrhosis. The Lancet. 2014; 383:1749.
- Feldman M, et al. Overview of Cirrhosis. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Oct. 8, 2015.
- Singal AK, et al. Model for end-stage liver disease. Journal of Clinical and Experimental Hepatology. 2013;3:50.
- Toshikuni N, et al. Nutrition and exercise in the management of liver cirrhosis. World Journal of Gastroenterology. 2014;20:7286.
- Cook AJ. AllScripts EPSi. Mayo Clinic, Rochester, Minn. Sept. 22, 2015.
- Goldberg E, et al. Cirrhosis in adults: Etiologies, clinical manifestations, and diagnosis. http://www.uptodate.com/home. Accessed Dec. 27, 2015.
- De Robertis R, et al. Noninvasive diagnosis of cirrhosis: A review of different imaging modalities. World Journal of Gastroenterology. 2014;20:7231.
- Czaja AJ. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World Journal of Gastroenterology. 2014;20:2515.
- Primary biliary cirrhosis (PBC). American Liver Foundation. http://www.liverfoundation.org/abouttheliver/info/pbc/. Accessed Dec. 27, 2015.
- Liver transplant. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/info/transplant/. Accessed Dec. 27, 2015.
- Rakel D. Chronic hepatitis. In: Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Dec. 7, 2015.
- Hepatitis C: A focus on dietary supplements. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/hepatitisc/hepatitiscfacts.htm. Accessed Dec. 27, 2015.
- U.S. News best hospitals 2013-2014. U.S. News & World Report. http://health.usnews.com/best-hospitals/rankings/gastroenterology-and-gi-surgery. Accessed Dec. 27, 2015.
- Singh S, et al. Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: A systematic review and meta-analysis. Clinical Gastroenterology and Hepatology. 2013;11:1573.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. Jan. 10, 2016.
- Keaveny AP (expert opinion). Mayo Clinic, Jacksonville, Fla. March 15, 2016.