Symptoms and causes

Symptoms

In some cases, carcinoid tumors don't cause any signs or symptoms. When they do occur, signs and symptoms are usually vague and depend on the location of the tumor.

Carcinoid tumors in the lungs

Signs and symptoms of carcinoid lung tumors include:

  • Chest pain
  • Wheezing
  • Shortness of breath
  • Diarrhea
  • Redness or a feeling of warmth in your face and neck (skin flushing)
  • Weight gain, particularly around the midsection and upper back
  • Pink or purple marks on the skin that look like stretch marks

Carcinoid tumors in the digestive tract

Signs and symptoms of carcinoid tumors in the digestive tract include:

  • Abdominal pain
  • Diarrhea
  • Nausea, vomiting and inability to pass stool due to intestinal blockage (bowel obstruction)
  • Rectal bleeding
  • Rectal pain
  • Redness or a feeling of warmth in your face and neck (skin flushing)

When to see a doctor

If you experience any signs and symptoms that bother you and are persistent, make an appointment with your doctor.

Causes

It's not clear what causes carcinoid tumors. In general, cancer occurs when a cell develops mutations in its DNA. The mutations allow the cell to continue growing and dividing when healthy cells would normally die.

The accumulating cells form a tumor. Cancer cells can invade nearby healthy tissue and spread to other parts of the body.

Doctors don't know what causes the mutations that can lead to carcinoid tumors. But they know that carcinoid tumors develop in neuroendocrine cells.

Neuroendocrine cells are found in various organs throughout the body. They perform some nerve cell functions and some hormone-producing endocrine cell functions. Some hormones that are produced by neuroendocrine cells are cortisol, histamine, insulin and serotonin.

Risk factors

Factors that increase the risk of carcinoid tumors include:

  • Older age. Older adults are more likely to be diagnosed with a carcinoid tumor than are younger people or children.
  • Sex. Women are more likely than men to develop carcinoid tumors.
  • Family history. A family history of multiple endocrine neoplasia, type I (MEN I), increases the risk of carcinoid tumors. In people with MEN I, multiple tumors occur in glands of the endocrine system.

Complications

The cells of carcinoid tumors can secrete hormones and other chemicals, causing a range of complications, including:

  • Carcinoid syndrome. Carcinoid syndrome causes redness or a feeling of warmth in your face and neck (skin flushing), chronic diarrhea, and difficulty breathing, among other signs and symptoms.
  • Carcinoid heart disease. Carcinoid tumors may secrete hormones that can cause thickening of the lining of heart chambers, valves and blood vessels. This can lead to leaky heart valves and heart failure that may require valve-replacement surgery. Carcinoid heart disease can usually be controlled with medications.
  • Cushing's syndrome. A lung carcinoid tumor can produce an excess of a hormone that can cause your body to produce too much of the hormone cortisol.
Dec. 03, 2015
References
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