Bone metastasis occurs when cancer cells break away from the original tumor and spread to the bones, where they begin to multiply. It's believed that cancer cells arrive in the bones by traveling through the blood vessels.
Doctors aren't sure what causes some cancers to spread. And it's not clear why some cancers travel to the bones rather than to other common sites for metastasis, such as the liver.
Apr. 27, 2012
- Walsh D, et al. Palliative Medicine. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-0-323-05674-8..X5001-4&isbn=978-0-323-05674-8&uniqId=325267977-3. Accessed March 23, 2012.
- Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008. http://www.mdconsult.com/das/book/body/208746819-4/0/1709/0.html. Accessed March 23, 2012.
- Canale ST, et al. Campbell's Operative Orthopaedics. 11th ed. Philadelphia, Pa.: Mosby Elsevier; 2008. http://www.mdconsult.com/das/book/body/208746819-4/0/1584/0.html. Accessed April 3, 2012.
- Browner BD, et al. Skeletal Trauma. 4th ed. Philadelphia, Pa.: Saunders Elsevier; 2009. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-1-4160-2220-6..X1000-6&isbn=978-1-4160-2220-6&uniqId=327645813-3. Accessed April 3, 2012.
- Paes FM, et al. Radiopharmaceuticals: When and how to use them to treat metastatic bone pain. Supportive Oncology. 2011;9:197.
- Rosenthal D, et al. Critical review of the state of the art in interventional oncology: Benign and metastatic disease involving bone. Radiology. 2012;262:765.
- Metastatic cancer. National Cancer Institute. http://cancer.gov/cancertopics/factsheet/Sites-Types/metastatic. Accessed March 23, 2012.
- Moynihan TJ (expert opinion). Mayo Clinic, Rochester, Minn. April 9, 2012.
You Are ... The Campaign for Mayo Clinic
Mayo Clinic is a not-for-profit organization. Make a difference today.