May 20, 2025
  1. Aspartate aminotransferase (AST) (GOT), serum. Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/overview/8360%20#Clinical-and-Interpretive. Accessed March 26, 2025.
  2. Friedman LS. Overview of liver biochemical tests. https://www.uptodate.com/contents/search. Accessed March 26, 2025.
  3. Langan RC, et al. Mildly elevated liver transaminase levels: Causes and evaluation. American Academy of Family Physicians. 2024. https://www.clinicalkey.com. Accessed April 23, 2025.
  4. Lee EY, et al. Health behavior associated with liver enzymes among obese Korean adolescents, 2009-2014. PLOS One. 2018; doi:10.1371/journal.pone.0190535.
  5. Youssef EM, et al. Subnormal serum liver enzyme levels: A review of pathophysiology and clinical significance. Journal of Clinical and Translational Hepatology. 2024; doi:10.14218/jcth.2023.00446.
  6. Mohamed MF, at al. Etiologies and outcomes of transaminase elevation >1000 IU/L: A systematic review and meta-analysis. Digestive Disease and Sciences. 2023; doi:10.1007/s10620-023-07962-w.
  7. Reutemann B, et al. Evaluation of patients with markedly abnormal liver enzymes. Clinics in Liver Disease. 2023; doi:10.1016/j.cld.2022.08.007.
  8. Rosenberg J, et al. Approach to elevated liver enzymes. Primary Care: Clinic in Office Practice. 2023; doi:10.1016/j.pop.2023.03.007.
  9. Tamber SS, et al. Biomarkers of liver disease. Molecular Biology Reports. 2023; doi:10.1007/s11033-023-08666-0.
  10. Aspartate aminotransferase (AST) test. Testing.com. https://www.testing.com/tests/aspartate-aminotransferase-ast/. Accessed May 5, 2025.
  11. McPherson RA, et al., eds. Evaluation of liver function. In: Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed May 5, 2025.
  12. Kalas MA, et al. Abnormal liver enzymes: A review for clinicians. World Journal of Hepatology. 2021; doi:10.4254/wjh.v13.i11.1688.
  13. Kwo PY, et al. ACG Clinical guideline: Evaluation of abnormal liver chemistries. American Journal of Gastroenterology. 2017; doi:10.1038/ajg.2016.517.
  14. Riedl JM, et al. The AST/ALT (De Ritis) ratio predicts clinical outcome in patients with pancreatic cancer treated with first-line nab-paclitaxel and gemcitabine. Therapeutic Advances In Medical Oncology. 2020; doi:10.1177/1758835919900872.
  15. Medical review (expert opinion). Mayo Clinic. April 11, 2025.
  16. Friedman S, et al., eds. Approach to abnormal liver tests. In: Greenberger's Current Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy. 4th ed. McGraw Hill; 2022. https://accessmedicine.mhmedical.com. Accessed April 10, 2025.
  17. Ferri FF. Laboratory tests and interpretation of results. In: Ferri's Clinical Advisor 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed May 6, 2025.
  18. Abnormal liver tests (adult). AskMayoExpert; 2024.

Aspartate aminotransferase (AST) blood test