神经科

以下为当前的临床试验。

按位置、状态和其他条件筛选该研究列表。

1. ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design.  FTLD is a neurodegenerative disorder of the nervous system which there are no approved treatments or cures.

   The study has two arms: a “longitudinal arm” involving a comprehensive assessment of clinical, functional, imaging, and biofluid data collection, and a “biofluid-focused arm” involving limited clinical data to accompany biospecimen collection.

2. A Study of Multicenter Outcomes in Pediatric Status Epilepticus

   Rochester, Minn.

   The purpose of this study is to develop a prospective status epilepticus registry among twelve tertiary care pediatric hospitals in the United States focused on standardizing status epilepticus outcome assessments.

3. A Study to Evaluate Rozanolixizumab to Treat Patients with Generalized Myasthenia Gravis

   Rochester, Minn.

   The purpose of this study is to assess the safety, tolerability, and effectiveness of additional 6-week treatment cycles with Rozanolixizumab in study participants with generalized myasthenia gravis.

4. Nicotinamide Riboside (NR) for Mitochondrial Myopathy Disorder Treatment

   Rochester, Minn.

   This study is a phase II, single-center, randomized, double blind, placebo-controlled trail of the efficacy of Nicotinamide Riboside, in the treatment of adult-onset Mitochondrial Myopathy.

5. Brain Tumor Repository

   Scottsdale/Phoenix, Ariz.

   The main objective of the Brain Tumor Repository is to allow access to coded patient data by researchers both inside and outside of the Mayo Clinic system so that important research questions can be answered.  

6. Image-based Mapping of Brain Tumors

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.

    

7. Innovative Trial for Understanding the Impact of Targeted Therapies in NF2

   Rochester, Minn.

   The purpose of this study is to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow people with multiple tumor types associated with NF2 to receive new drugs throughout this study. Embedded within the Master Study are individual drug substudies. - Investigational Drug Sub-study A: Brigatinib.

8. A Study to Develop Liquid Biopsy for Pediatric Brain Tumor Patients

   Rochester, Minn.

   The purpose of this study is to confirm detection of the H3K27M mutation in patient biofluids (CSF, blood, urine, saliva) and uncover the molecular histone (alkaline protein) profile of H3K trimethylation and H3S phosphorylation in the circulating nucleosomes isolated from the biofluids of patients with H3K27M tumors.

9. Inherited Muscle Diseases Repository

   Rochester, Minn.

   To establish a repository of DNA samples collected prospectively from patients with inherited myopathies of unknown molecular and/or biochemical defect. To access residual muscle specimens from diagnostic muscle biopsies obtained as part of the routine medical care. The biospecimens will be used to better understanding the underlying molecular defects and mechanisms of muscle diseases.

10. Brain Health and Dementia Prevention Registry

    Jacksonville, Fla.

    The purpose of this study is to create a registry of patients having a clinical diagnosis and collect demographics, cognitive testing, blood and cerebrospinal fluid so that biomarkers and genetic difference can be found in different patient groups.