Yan Bi, M.D., Ph.D.

  1. Gastroenterologist
  2. Internist

出版物

  1. Zhang Y, Ma Y, Wang Y, Mukhopadhyay D, Bi Y, Ji B. Aurora kinase a inhibitor MLN8237 suppresses pancreatic cancer growth. Pancreatology. 2022 Apr 13 [Epub ahead of print]
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  2. Gonda TA, Farrell J, Wallace M, Khanna L, Janec E, Kwon R, Saunders M, Siddiqui UD, Brand R, Simeone DM, PRECEDE Consortium. Standardization of EUS imaging and reporting in high-risk individuals of pancreatic adenocarcinoma: consensus statement of the Pancreatic Cancer Early Detection Consortium. Gastrointest Endosc. 2022 Apr; 95 (4):723-732.e7 Epub 2021 Nov 02
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  3. Wang J, Wan J, Wang L, Pandol SJ, Bi Y, Ji B. Wild-Type Human PRSS2 and PRSS1(R122H) Cooperatively Initiate Spontaneous Hereditary Pancreatitis in Transgenic Mice. Gastroenterology. 2022 Mar 11 [Epub ahead of print]
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  4. Montenegro ML, Corral JE, Lukens FJ, Ji B, Kroner PT, Farraye FA, Bi Y. Pancreatic Disorders in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2022 Feb; 67 (2):423-436 Epub 2021 Feb 24
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  5. Bajaj, Unnati, Stevi , Jordan, Yan Bi. Necrotizing pancreatitis in a COVID-19 patient managed with endoscopic AXIOS stent placement International Journal of Gastrointestinal Intervention. 2022.
  6. Cortes P, Harris DM, Bi Y. Systematic Approach to Celiac Disease: A Comprehensive Review for Primary Providers. Rom J Intern Med. 2022 Jan 29 [Epub ahead of print]
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  7. Wang J, Wang O, Bi Y, Wang Y, Crawford H, Ji B. Ptf1a Promoter-Driven Cre Expression During Spermatogenesis Causes Germline Recombination. Pancreas. 2022 Jan 1; 51 (1):90-93
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  8. Cortez Pedro, Raimondo Massimo, Wallace Michael, Bi Yan. The role of endoscopic ultrasound and magnetic resonance cholangiopancreatography in the diagnosis of idiopathic recurrent acute pancreatitis: a narrative review Dig Med Res. 2021; 4(69):21-66.
  9. Harris DM, Stancampiano FF, Burton MC, Moyer AM, Schuh MJ, Valery JR, Bi Y. Use of Pharmacogenomics to Guide Proton Pump Inhibitor Therapy in Clinical Practice. Dig Dis Sci. 2021 Dec; 66 (12):4120-4127 Epub 2021 Jan 21
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  10. Gonda TA, Everett JN, Wallace M, Simeone DM, PRECEDE Consortium. Recommendations for a More Organized and Effective Approach to the Early Detection of Pancreatic Cancer From the PRECEDE (Pancreatic Cancer Early Detection) Consortium. Gastroenterology. 2021 Dec; 161 (6):1751-1757 Epub 2021 Aug 27
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  11. Kroner PT, Wallace MB, Raimondo M, Antwi SO, Ma Y, Li Z, Ji B, Bi Y. Systemic anticoagulation is associated with decreased mortality and morbidity in acute pancreatitis. Pancreatology. 2021 Dec; 21 (8):1428-1433 Epub 2021 Sept 08
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  12. Zaver HB, Ghoz H, Malviya BJ, Brahmbhatt B, Palmer WC, Lacy BE, DeVault KR, Krishna M, Bi Y. Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes. Dig Dis Sci. 2021 Nov; 66 (11):3976-3984 Epub 2020 Nov 20
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  13. Bajaj S, Barrett SM, Nakhleh RE, Brahmbhatt B, Bi Y. Umbralisib-Induced Immune-Mediated Colitis: A Concerning Adverse Effect of the Novel PI3Kdelta/CK1epsilon Inhibitor. ACG Case Rep J. 2021 Nov; 8 (11):e00701 Epub 2021 Nov 24
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  14. Cruz LM, Kwon JY, Oman SP, Zaver H, Bolanos GA, Kroner PT, Raimondo M, Bi Y, Lukens FJ, Corral JE. Comparison of idiopathic recurrent acute pancreatitis [IRAP] and recurrent acute pancreatitis with genetic mutations. Dig Liver Dis. 2021 Oct; 53 (10):1294-1300 Epub 2021 May 07
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  15. Wan J, Wang J, Wagner LE 2nd, Wang OH, Gui F, Chen J, Zhu X, Haddock AN, Edenfield BH, Haight B, Mukhopadhyay D, Wang Y, Yule DI, Bi Y, Ji B. Pancreas-specific CHRM3 activation causes pancreatitis in mice. JCI Insight. 2021 Sep 8; 6 (17) Epub 2021 Sept 08
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  16. Cortes P, Bi Y, Stancampiano F, Valery JR, Cooper JH, Harris DM. Clostridioides difficile infection: a comprehensive review for primary providers. Rom J Intern Med. 2021 Sep 1; 59 (3):262-269 Epub 2021 Aug 26
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  17. Liu Y, Raimondo M, Wallace MB, Mody K, Stauffer JA, Zhang L, Ji B, Bi Y. Exome Sequencing of Pancreatic Acinar Carcinoma Identified Distinctive Mutation Patterns. Pancreas. 2021 Aug 1; 50 (7):1007-1013
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  18. Cortes P, Ghoz HM, Mzaik O, Alhaj Moustafa M, Bi Y, Brahmbhatt B, Daoud N, Pang M. Colchicine as an Alternative First-Line Treatment of Sclerosing Mesenteritis: A Retrospective Study. Dig Dis Sci. 2021 Jun 4 Epub 2021 June 04
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  19. Nelson A, Bi Y, Harris D. Helicobacter Pylori: a comprehensive review for primary care providers. Rom J Intern Med. 2021 Jun 1; 59 (2):112-118 Epub 2021 May 08
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  20. Bi Y, LeGout JD, Lukens FJ. A Rare Cause of Shortness of Breath. Clin Gastroenterol Hepatol. 2021 Mar; 19 (3):e28 Epub 2020 Feb 07
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  21. Corral JE, Croome KP, Keaveny AP, Brahmbhatt B, Bartel MJ, Kroner PT, Wijarnpreecha K, Goswami RM, Raimondo M, Wallace MB, Bi Y, Mousa OY. A 3-Decade Analysis of Pancreatic Adenocarcinoma After Solid Organ Transplant. Pancreas. 2021 Jan 1; 50 (1):54-63
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  22. Cortes P, Nelson AD, Bi Y, Stancampiano FF, Murray LP, Pujalte GGA, Gomez V, Harris DM. Treatment Approach of Refractory Helicobacter pylori Infection: A Comprehensive Review. J Prim Care Community Health. 2021 Jan-Dec; 12:21501327211014087
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  23. Cai W, Liu F, Wen Y, Han C, Prasad M, Xia Q, Singh VK, Sutton R, Huang W, Bi Yan. Pain Management in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Front Med (Lausanne). 2021; 8:782151 Epub 2021 Dec 17
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  24. Ali AH, Bi Y, Machicado JD, Garg S, Lennon RJ, Zhang L, Takahashi N, Carey EJ, Lindor KD, Buness JG, Tabibian JH, Chari ST. The long-term outcomes of patients with immunoglobulin G4-related sclerosing cholangitis: the Mayo Clinic experience. J Gastroenterol. 2020 Nov; 55 (11):1087-1097 Epub 2020 Aug 08
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  25. Corral JE, Kroner PT, Yarlagadda B, Vemireddy LPR, Wijarnpreecha K, Goswami RM, Raimondo M, Bi Y. Left Ventricular Assist Device Therapy and Acute Pancreatitis: Higher Incidence and Worse Clinical Outcomes. Pancreas. 2020 Sep; 49 (8):1069-1074
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  26. Huang H, Swidnicka-Siergiejko AK, Daniluk J, Gaiser S, Yao Y, Peng L, Zhang Y, Liu Y, Dong M, Zhan X, Wang H, Bi Y, Li Z, Ji B, Logsdon CD. Transgenic Expression of PRSS1R122H Sensitizes Mice to Pancreatitis. Gastroenterology. 2020 Mar; 158(4):1072-1082.e7. Epub 2019 Aug 13.
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  27. Gui F, Zhang Y, Wan J, Zhan X, Yao Y, Li Y, Haddock AN, Shi J, Guo J, Chen J, Zhu X, Edenfield BH, Zhuang L, Hu C, Wang Y, Mukhopadhyay D, Radisky ES, Zhang L, Lugea A, Pandol SJ, Bi Y, Ji B. Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. J Clin Invest. 2020 Jan 2; 130 (1):189-202
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  28. Zhan X, Wan J, Zhang G, Song L, Gui F, Zhang Y, Li Y, Guo J, Dawra RK, Saluja AK, Haddock AN, Zhang L, Bi Y, Ji B. Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2019 Jun 1; 316 (6):G816-G825 Epub 2019 Apr 03
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  29. Zhuang L, Zhan X, Bi Y, Ji B. Induction of Pancreatic Inflammation Accelerates Pancreatic Tumorigenesis in Mice. Methods Mol Biol. 2019; 1882:287-297
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  30. Huang H, Chen J, Peng L, Yao Y, Deng D, Zhang Y, Liu Y, Wang H, Li Z, Bi Y, Haddock AN, Zhan X, Lu W, Logsdon CD, Ji B. Transgenic expression of cyclooxygenase-2 in pancreatic acinar cells induces chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1; 316 (1):G179-G186 Epub 2018 Nov 15
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  31. Zhang Yuebo, Zhan Xianbao, Zhang Guowei, Zhuang Lu, Li Yinghua, Bi Yan, Ji Baoan. Mutant Human PRSS1 R122H Expression in Mice Greatly Exacerbates Pancreatitis Gastroenterology. 2017; 152(5):S893.
  32. de Pretis N, Mukewar S, Aryal-Khanal A, Bi Y, Takahashi N, Chari S. Pancreatic cysts: Diagnostic accuracy and risk of inappropriate resections. Pancreatology. 2017 Mar - Apr; 17 (2):267-272 Epub 2017 Jan 12
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  33. Zhan X, Wang F, Bi Y, Ji B. Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1; 311 (3):G343-55 Epub 2016 July 14
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  34. Zhan X, Wang F, Bi Y, Ji B. Animal models of gastrointestinal and liver diseases. animal models of acute and chronic pancreatitis American Journal Of Physiology-Gastrointestinal And Liver Physiology. 2016 Sep 1; 311: (3)G343-55.
  35. Bi Y, Ji B. Spontaneous Pancreatitis in Genetically Modified Animal Strains Pancreapedia: Exocrine Pancreas Knowledge Base .2016;
  36. Bi Y, Hart PA, Law R, Clain JE, Farnell MB, Gleeson FC, Kendrick ML, Levy MJ, Pearson RK, Petersen BT, Pisney LD, Smyrk TC, Takahashi N, Topazian MD, Vege SS, Chari ST. Obstructive jaundice in autoimmune pancreatitis can be safely treated with corticosteroids alone without biliary stenting. Pancreatology. 2016 May-Jun; 16: (3)391-6.
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  37. Bi Y, Atwal T, Vege SS. Drug Therapy for Acute Pancreatitis. Curr Treat Options Gastroenterol. 2015 Sep; 13 (3):354-68
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  38. Vege SS, Atwal T, Bi Y, Chari ST, Clemens MA, Enders FT. Pentoxifylline Treatment in Severe Acute Pancreatitis: A Pilot, Double-Blind, Placebo-Controlled, Randomized Trial. Gastroenterology. 2015 Aug; 149 (2):318-20.e3 Epub 2015 June 23
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  39. Hart PA, Baichoo E, Bi Y, Hinton A, Kudva YC, Chari ST. Pancreatic polypeptide response to a mixed meal is blunted in pancreatic head cancer associated with diabetes mellitus. Pancreatology. 2015 Mar-Apr; 15 (2):162-6 Epub 2015 Feb 24
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  40. Simonetto DA, Yang HY, Yin M, de Assuncao TM, Kwon JH, Hilscher M, Pan S, Yang L, Bi Y, Beyder A, Cao S, Simari RD, Ehman R, Kamath PS, Shah VH. Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. Hepatology. 2015 Feb; 61 (2):648-59 Epub 2015 Jan 05
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  41. Bi Y, Mukhopadhyay D, Drinane M, Ji B, Li X, Cao S, Shah VH. Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. Am J Physiol Cell Physiol. 2014 Oct 1; 307 (7):C622-33 Epub 2014 July 30
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  42. Bi Y, Li J, Ji B, Kang N, Yang L, Simonetto DA, Kwon JH, Kamath M, Cao S, Shah V. Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. Am J Pathol. 2014 Oct; 184 (10):2791-802 Epub 2014 Aug 08
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  43. Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014 May; 146 (5):1339-50.e1 Epub 2014 Feb 04
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  44. Bi Y, Venkatesh SK, Shah VH. Detecting fibrosis without a liver biopsy: getting to the fat of the issue. Hepatol Int. 2013 Jul; 7 (3):792-4 Epub 2013 July 18
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  45. Luther G, Wagner ER, Zhu G, Kang Q, Luo Q, Lamplot J, Bi Y, Luo X, Luo J, Teven C, Shi Q, Kim SH, Gao JL, Huang E, Yang K, Rames R, Liu X, Li M, Hu N, Liu H, Su Y, Chen L, He BC, Zuo GW, Deng ZL, Reid RR, Luu HH, Haydon RC, He TC. BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Curr Gene Ther. 2011 Jun; 11 (3):229-40
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  46. Wagner ER, Luther G, Zhu G, Luo Q, Shi Q, Kim SH, Gao JL, Huang E, Gao Y, Yang K, Wang L, Teven C, Luo X, Liu X, Li M, Hu N, Su Y, Bi Y, He BC, Tang N, Luo J, Chen L, Zuo G, Rames R, Haydon RC, Luu HH, He TC. Defective osteogenic differentiation in the development of osteosarcoma. Sarcoma. 2011; 2011:325238 Epub 2011 Feb 22
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  47. Teven CM, Liu X, Hu N, Tang N, Kim SH, Huang E, Yang K, Li M, Gao JL, Liu H, Natale RB, Luther G, Luo Q, Wang L, Rames R, Bi Y, Luo J, Luu HH, Haydon RC, Reid RR, He TC. Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation. Stem Cells Int. 2011; 2011:201371 Epub 2011 July 11
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  48. Sabbatini ME, Bi Y, Ji B, Ernst SA, Williams JA. CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini. Am J Physiol Cell Physiol. 2010 Mar; 298: (3)C592-601.
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  49. Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, Daniluk J, Bi Y, Grote T, Longnecker DS, Logsdon CD. Ras activity levels control the development of pancreatic diseases. Gastroenterology. 2009 Sep; 137: (3)1072-82, 1082.e1-6.
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  50. Boonyaratanakornkit V, Bi Y, Rudd M, Edwards DP. The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression. Steroids. 2008 Oct; 73: (9-10)922-8.
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  51. Ji B, Song J, Tsou L, Bi Y, Gaiser S, Mortensen R, Logsdon C. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis. 2008 Aug; 46: (8)390-5.
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  52. Bi Y, Page SL, Williams JA. Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289: (3)G561-70.
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  53. Bi Y, Williams JA. A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini. Am J Physiol Cell Physiol. 2005 Jul; 289: (1)C22-32.
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  54. Bi Y, Williams JA. Receptor biology and signal transduction in pancreatic acinar cells. Curr Opin Gastroenterol. 2004 Sep; 20: (5)427-34.
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  55. Le Page SL, Bi Y, Williams JA. CCK-A receptor activates RhoA through G alpha 12/13 in NIH3T3 cells. Am J Physiol Cell Physiol. 2003 Nov; 285: (5)C1197-206.
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  56. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacol Toxicol. 2002 Dec; 91: (6)327-32.
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  57. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology. 2001 Dec; 121: (6)1380-90.
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PST-20215940