Transplant Medicine

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estado, etc.

1. Study of Blood Pressure Evaluation with Continuous Flow Left Ventricular Assist Devices

   Jacksonville, Fla.

   The primary purpose of this study is to evaluate the ability for tonometry to accurately reproduce blood pressure readings in patients with left ventricular assist devices (LVAD).

2. A Study to Evaluate the Role of Gut Microbiome in Cancer Therapy

   Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to correlate gut microbiome with specific cancer diagnoses and the clinical response (effectiveness), and adverse effects of cancer therapy (single or multiple) and stem cell transplant.

    

3. A Study to Analyze Tacrolimus Metabolism in Heart Transplant Patients

   Jacksonville, Fla.

   The puprose of this study is to evaluate pharmacogenomic differences of CYP 3A5 in heart transplant patients, to determine dose ranges and pharmacodynamics properties of tacrolimus metabolism based on CYP 3A5 genotype/phenotype combinations, and to assess whether CYP3A5 polymorphism influences post-transplant outcomes including survival, rejection and infection rates.

4. Trimethoprim-sulfamethoxazole Graded Administration in Oncology, Hematopoietic Stem Cell Transplant, and Solid Organ Transplant Patients with a History of Sulfonamide Allergy

   Rochester, Minn.

   The aim of this study is to study the efficacy and safety of our short and long one-day protocols for TMP-SMX graded administration in hematologic malignancy, hematopoietic stem cell transplant, and solid organ transplant patients.    

5. A Study Looking at the Impact of Gabriel House of Care (a Hospital Hospitality House, HHH) on the Quality of Life and Mood of Liver Transplant Patients

   Jacksonville, Fla.

   The aim of this study is to measure the differences in quality of life and mood of liver transplant recipients in the immediate month post- transplant staying at the Gabriel House of Care staying at a hotel, apartment or rental property. 

6. A Study to Evaluate Fertility, Sexual Function, and Endothelial Health in Premenopausal Women with Kidney Disease

   Rochester, Minn.

   The purpose of this study is to evaluate how advancing stages of chronic kidney disease (CKD) may impact the hypothalamic-pituitary-gonadal axis,and how alterations in sex hormones and menstrual cycles correlate with changes in endothelial health and sexual function before and after transplant.

7. A Study to Assess Older Adults Applying Pre-transplant Comorbidity, Geriatric Assessment and Biomarkers to Predict Non-Relapse Mortality After Allogeneic Transplant (CHARM)

   Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to determine the set of assessments and biomarkers that could together constitute a robust and valid composite health risk model for accurate personalized estimation of one year NRM.

8. A Pilot Study Examining Thiamine Deficiency in Patients Admitted to the Hospital for Liver Transplantation

   Jacksonville, Fla.

   The purpose of this study is to report the proportion of thiamine deficiency (as defined by the Mayo Clinic Laboratory reference range) in liver transplant patients.

9. Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission

   Rochester, Minn., Jacksonville, Fla.

   This randomized phase III trial studies rituximab after stem cell transplant and to see how well it works compared with rituximab alone in treating patients with in minimal residual disease-negative mantle cell lymphoma in first complete remission. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Giving chemotherapy before a stem cell transplant helps kill any cancer cells that are in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Giving rituximab with or without stem cell transplant may work better in treating patients with mantle cell lymphoma.

10. Hematopoietic Stem Cell Transplant Survivors Study (HTSS Study)

    Rochester, Minn.

    The investigators hope to find the proof of principle concept from this pilot study so that the investigators can design a clinical trial based on the results of the explanatory hypothesis.