Proper Use

Drug information provided by: Merative, Micromedex®

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may cause your lung condition to become worse.

This medicine usually comes with patient instructions. Read them carefully before using the medicine. If you do not understand the directions or you are not sure how to use the nebulizer, ask your doctor to show you how to use it.

Dornase alfa should be used with the eRapid™ nebulizer system or a jet nebulizer that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth. To use:

  • Dornase alfa inhalation solution comes in small plastic containers called ampules. Each ampule contains one full dose of dornase alfa. Do not use an ampule that has already been opened. Do not use a cloudy or discolored inhalation solution.
  • Remove the ampule from the pouch. Place the inhalation solution in the medicine reservoir or nebulizer cup on the machine.
  • Connect the nebulizer to the face mask or mouthpiece, then connect the nebulizer to the compressor.
  • Use the mouthpiece of the nebulizer to breathe in Pulmozyme®. Do not use a face mask with the nebulizer because less medicine will get into your lungs.
  • Patients who are unable to breathe in or breathe out by mouth may use the PARI BABY™ nebulizer with the supplied face mask. Make sure you understand exactly how to use this medicine in the nebulizer.
  • Use the nebulizer for about 10 to 15 minutes, or until the medicine in the nebulizer cup is gone.
  • Follow the manufacturer's directions for care and cleaning of the nebulizer and compressor.
  • Do not mix any other medicine in the nebulizer with dornase alfa.

In order to receive the full effects of this medicine, you must use it every day as ordered by your doctor. If possible, dornase alfa should be used at about the same time each day. You may notice some improvement in your condition within the first week of treatment. However, some patients may not feel the full effects of this medicine for weeks or months.

If you are taking any other medicines for cystic fibrosis, keep taking them as you did before you started using dornase alfa, unless otherwise directed by your doctor. However, do not put any other inhaled medicine in the nebulizer at the same time that you use dornase alfa. Other inhaled medicines may be used in a clean nebulizer before or after your treatment with dornase alfa.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For inhalation dosage form (solution):
    • For cystic fibrosis:
      • Adults and children 5 years of age and older—2.5 milligrams (mg) (one ampule) once a day in the nebulizer.
      • Children 3 months to 4 years of age—Dose must be determined by your doctor. The dose is usually 2.5 mg (one ampule) once a day in the nebulizer.
      • Children younger than 3 months of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in the refrigerator in the foil pouches. However, keep the medicine from freezing. Do not leave this medicine out of the refrigerator for longer than 24 hours. If an ampule of medicine is left out for longer than this, it should be thrown away and a new ampule should be used.