Publicaciones Imprimir Rashed HR, Staff NP, Milone M, Mauermann ML, Berini S, Cheshire WP, Coon EA, Fealey RD, Sorenson E, Cutsforth-Gregory J, Benarroch EE, Sandroni P, Low PA, Singer W, Shouman K. Autonomic impairment in primary lateral sclerosis. Clin Auton Res. 2024 Jun 12 Epub 2024 June 12 View PubMed Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez-Atienzar S, Reho P, Kaivola K, Walton RL, Reynolds RH, Karra R, Sait S, Akcimen F, Diez-Fairen M, Alvarez I, Fanciulli A, Stefanova N, Seppi K, Duerr S, Leys F, Krismer F, Sidoroff V, Zimprich A, Pirker W, Rascol O, Foubert-Samier A, Meissner WG, Tison F, Pavy-Le Traon A, Pellecchia MT, Barone P, Russillo MC, Marin-Lahoz J, Kulisevsky J, Torres S, Mir P, Perinan MT, Proukakis C, Chelban V, Wu L, Goh YY, Parkkinen L, Hu MT, Kobylecki C, Saxon JA, Rollinson S, Garland E, Biaggioni I, Litvan I, Rubio I, Alcalay RN, Kwei KT, Lubbe SJ, Mao Q, Flanagan ME, Castellani RJ, Khurana V, Ndayisaba A, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Moore A, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Kim C, Iba M, Masliah E, Dawson TM, Rosenthal LS, Pantelyat A, Albert MS, Pletnikova O, Troncoso JC, Infante J, Lage C, Sanchez-Juan P, Serrano GE, Beach TG, Pastor P, Morris HR, Albani D, Clarimon J, Wenning GK, Hardy JA, Ryten M, Topol E, Torkamani A, Chio A, Bennett DA, De Jager PL, Low PA, Singer W, Cheshire WP, Wszolek ZK, Dickson DW, Traynor BJ, Gibbs JR, Dalgard CL, Ross OA, Houlden H, Scholz SW. Genome sequence analyses identify novel risk loci for multiple system atrophy. Neuron. 2024 Apr 24 [Epub ahead of print] View PubMed Gibbons CH, Levine T, Adler C, Bellaire B, Wang N, Stohl J, Agarwal P, Aldridge GM, Barboi A, Evidente VGH, Galasko D, Geschwind MD, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis M, Reynolds A, Sahagian GA, Saint-Hillaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Yerstein O, Freeman R. Skin Biopsy Detection of Phosphorylated alpha-Synuclein in Patients With Synucleinopathies. JAMA. 2024 Apr 16; 331 (15):1298-1306 View PubMed Rasmussen TK, Borghammer P, Finnerup NB, Jensen TS, Hansen J, Knudsen K, Singer W, Lamotte G, Terkelsen AJ. Functional and (123)I-MIBG scintigraphy assessment of cardiac adrenergic dysfunction in diabetes. Auton Neurosci. 2024 Apr; 252:103155 Epub 2024 Feb 07 View PubMed Badihian N, Savica R, Adler CH, Wszolek ZK, Jackson LM, Benarroch EE, Sandroni P, Low PA, Singer W, Coon EA. Clinical Characteristics and Outcomes in Young-Onset Multiple System Atrophy. Mov Disord Clin Pract. 2024 Mar; 11 (3):220-226 Epub 2023 Nov 23 View PubMed Millar Vernetti P, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Shibao CA, Peltier A, Freeman R, Gibbons C, Goldstein DS, Low PA, Singer W, Coon EA, Miglis MG, Wenning GK, Fanciulli A, Vernino S, Betensky RA, Kaufmann H. Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study. Brain. 2024 Feb 15 [Epub ahead of print] View PubMed Singer W, Schmeichel AM, Sletten DM, Gehrking TL, Gehrking JA, Trejo-Lopez J, Suarez MD, Anderson JK, Bass PH, Lesnick TG, Low PA. Neurofilament light chain in spinal fluid and plasma in multiple system atrophy: a prospective, longitudinal biomarker study. Clin Auton Res. 2023 Dec; 33 (6):635-645 Epub 2023 Aug 21 View PubMed Rasmussen VF, Schmeichel A, Thrysoe M, Nyengaard JR, Christensen AR, Vestergaard ET, Kristensen K, Terkelsen AJ, Karlsson P, Singer W. Sweat gland nerve fiber density and association with sudomotor function, symptoms, and risk factors in adolescents with type 1 diabetes. Clin Auton Res. 2023 Dec; 33 (6):691-703 Epub 2023 Sept 08 View PubMed Rasmussen VF, Thrysoe M, Randel Nyengaard J, Tankisi H, Karlsson P, Hansen J, Krogh K, Brock C, Kamperis K, Madsen M, Singer W, Vestergaard ET, Kristensen K, Terkelsen AJ. Corrigendum to "Neuropathy in adolescents with type 1 diabetes: Confirmatory diagnostic tests, bedside tests, and risk factors" [Diab. Res. Clin. Pract. 201 (2023) 110736]. Diabetes Res Clin Pract. 2023 Nov; 205:110950 Epub 2023 Oct 17 View PubMed Rasmussen VF, Thrysoe M, Nyengaard JR, Tankisi H, Karlsson P, Hansen J, Krogh K, Brock C, Kamperis K, Madsen M, Singer W, Vestergaard ET, Kristensen K, Terkelsen AJ. Corrigendum to "neuropathy in adolescents with type 1 diabetes: confirmatory diagnostic tests, bedside tests, and risk factors"[Diab. Res. Clin. Pract. 201 (2023) 110736]. Diabetes Research and Clinical Practice. 2023 Nov; 205:110950 Kissoon NR, LeMahieu AM, Stoltenberg AD, Bendel MA, Lamer TJ, Watson JC, Sletten DM, Singer W. Quantitative assessment of painful diabetic peripheral neuropathy after high-frequency spinal cord stimulation: a pilot study. Pain Med. 2023 Oct 13; 24(Supplement_2):S41-S47. View PubMed Rasmussen VF, Thrysoe M, Nyengaard JR, Tankisi H, Karlsson P, Hansen J, Krogh K, Brock C, Kamperis K, Madsen M, Singer W, Vestergaard ET, Kristensen K, Terkelsen AJ. Neuropathy in adolescents with type 1 diabetes: Confirmatory diagnostic tests, bedside tests, and risk factors. Diabetes Res Clin Pract. 2023 Jul; 201:110736 Epub 2023 June 03 View PubMed Schipani BE, Bailey ES, Hooshmand SJ, Badihian N, Sandroni P, Benarroch EE, Bower JH, Low PA, Singer W, Coon EA. Sex and Gender Influence Urinary Symptoms and Management in Multiple System Atrophy. J Mov Disord. 2023 May; 16 (2):196-201 Epub 2023 May 24 View PubMed Lamotte G, Singer W. Synucleinopathies. Handb Clin Neurol. 2023; 196:175-202 View PubMed Krismer F, Palma JA, Calandra-Buonaura G, Stankovic I, Vignatelli L, Berger AK, Falup-Pecurariu C, Foubert-Samier A, Hoglinger G, Kaufmann H, Kellerman L, Kim HJ, Klockgether T, Levin J, Martinez-Martin P, Mestre TA, Pellecchia MT, Perlman S, Qureshi I, Rascol O, Schrag A, Seppi K, Shang H, Stebbins GT, Wenning GK, Singer W, Meissner WG. The Unified Multiple System Atrophy Rating Scale: Status, Critique, and Recommendations. Mov Disord. 2022 Dec; 37 (12):2336-2341 Epub 2022 Sept 08 View PubMed Rasmussen TK, Finnerup NB, Singer W, Jensen TS, Hansen J, Terkelsen AJ. Preferential impairment of parasympathetic autonomic function in type 2 diabetes. Auton Neurosci. 2022 Dec; 243:103026 Epub 2022 Sept 15 View PubMed Vemuri P, Castillo AM, Thostenson KB, Ward CP, Raghavan S, Reid RI, Lesnick TG, Reddy AL, Gehrking TL, Gehrking JA, Sletten DM, Jack CR Jr, Low PA, Singer W. Imaging biomarkers for early multiple system atrophy. Parkinsonism Relat Disord. 2022 Oct; 103:60-68. Epub 2022 Aug 28. View PubMed Singer W. Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review. Clin Auton Res. 2022 Aug; 32 (4):291-297 Epub 2022 July 27 View PubMed Hilz MJ, Wang R, Singer W. Validation of the Composite Autonomic Symptom Score 31 in the German language. Neurol Sci. 2022 Jan; 43 (1):365-371 Epub 2021 Nov 25 View PubMed Lucien F, Benarroch EE, Mullan A, Ali F, Boeve BF, Mielke MM, Petersen RC, Kim Y, Stang C, Camerucci E, Ross OA, Wszolek ZK, Knopman D, Bower J, Singer W, Savica R. Poly (ADP-Ribose) and alpha-synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity. PLoS One. 2022; 17 (4):e0264446 Epub 2022 Apr 08 View PubMed Lamotte G, Coon EA, Suarez MD, Sandroni P, Benarroch E, Cutsforth-Gregory JK, Mauermann ML, Berini SE, Shouman K, Sletten D, Goodman BP, Low PA, Singer W. Standardized Autonomic Testing in Patients With Probable Radiation-Induced Afferent Baroreflex Failure. Hypertension. 2022 Jan; 79(1):50-56. Epub 2021 Nov 05. View PubMed Badihian N, Jackson LM, Klassen BT, Hassan A, Low PA, Singer W, Coon EA. The Effects of Deep Brain Stimulation in Patients with Multiple System Atrophy. J Parkinsons Dis 2022; 12 (8):2595-2600 View PubMed Johnson SA, Shouman K, Shelly S, Sandroni P, Berini SE, Dyck PJB, Hoffman EM, Mandrekar J, Niu Z, Lamb CJ, Low PA, Singer W, Mauermann ML, Mills J, Dubey D, Staff NP, Klein CJ. Small Fiber Neuropathy Incidence, Prevalence, Longitudinal Impairments, and Disability. Neurology. 2021 Nov 30; 97 (22):e2236-e2247 Epub 2021 Oct 27 View PubMed Lamotte G, Sandroni P, Cutsforth-Gregory JK, Berini SE, Benarroch EE, Shouman K, Mauermann ML, Anderson J, Low PA, Singer W, Coon EA. Clinical presentation and autonomic profile in Ross syndrome. J Neurol. 2021 Oct; 268 (10):3852-3860 Epub 2021 Apr 03 View PubMed Schmeichel AM, Coon EA, Parisi JE, Singer W, Low PA, Benarroch EE. Loss of putative GABAergic neurons in the ventrolateral medulla in multiple system atrophy. Sleep. 2021 Sep 13; 44 (9) View PubMed Lamotte G, Coon EA, Suarez MD, Sandroni P, Benarroch EE, Cutsforth-Gregory JK, Mauermann ML, Berini SE, Shouman K, Sletten D, Goodman BP, Low PA, Singer W. Natural History of Afferent Baroreflex Failure in Adults. Neurology. 2021 Jul 13; 97(2):e136-e144. Epub 2021 May 04. View PubMed Shouman K, Vanichkachorn G, Cheshire WP, Suarez MD, Shelly S, Lamotte GJ, Sandroni P, Benarroch EE, Berini SE, Cutsforth-Gregory JK, Coon EA, Mauermann ML, Low PA, Singer W. Autonomic dysfunction following COVID-19 infection: an early experience. Clin Auton Res. 2021 Jun; 31 (3):385-394 Epub 2021 Apr 16 View PubMed Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL, Gehrking JA, Olson AD, Suarez MD, Misra PP, Soto C, Low PA. Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure. Ann Neurol. 2021 Jun; 89(6):1212-1220. Epub 2021 Apr 30. View PubMed Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano T, Kim HA, Kimpinski K, Iodice V, Idiaquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Corrigendum to "Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology" [Clin. Neurophysiol. 132(2) (2021) 666-682]. Clin Neurophysiol. 2021 May; 132 (5):1194 Epub 2021 Mar 06 View PubMed Stankovic I, Fanciulli A, Kostic VS, Krismer F, Meissner WG, Palma JA, Panicker JN, Seppi K, Wenning GK, MoDiMSA Study Group. Laboratory-Supported Multiple System Atrophy beyond Autonomic Function Testing and Imaging: A Systematic Review by the MoDiMSA Study Group. Mov Disord Clin Pract. 2021 Apr; 8 (3):322-340 Epub 2021 Mar 10 View PubMed Palma JA, Vernetti PM, Perez MA, Krismer F, Seppi K, Fanciulli A, Singer W, Low P, Biaggioni I, Norcliffe-Kaufmann L, Pellecchia MT, Marti MJ, Kim HJ, Merello M, Stankovic I, Poewe W, Betensky R, Wenning G, Kaufmann H. Limitations of the Unified Multiple System Atrophy Rating Scale as outcome measure for clinical trials and a roadmap for improvement. Clin Auton Res. 2021 Apr; 31 (2):157-164 Epub 2021 Feb 07 View PubMed Brinth L, Pors K, Mehlsn J, Sletten DM, Terkelsen AJ, Singer W. Translation and linguistic validation of the Composite Autonomic Symptom Score COMPASS 31 in Danish. Dan Med J. 2021 Feb 09; 69(3). View PubMed Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiaquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. Clin Neurophysiol. 2021 Feb; 132 (2):666-682 Epub 2020 Dec 22 View PubMed Wernick AI, Walton RL, Soto-Beasley AI, Koga S, Heckman MG, Valentino RR, Milanowski LM, Hoffman-Zacharska D, Koziorowski D, Hassan A, Uitti RJ, Cheshire WP, Singer W, Wszolek ZK, Dickson DW, Low PA, Ross OA. Frequency of spinocerebellar ataxia mutations in patients with multiple system atrophy. Clin Auton Res. 2021 Feb; 31 (1):117-125 Epub 2021 Jan 27 View PubMed Jagadish S, Singer W, Kotagal S. Autonomic dysfunction in childhood hypersomnia disorders. Sleep Med. 2021 Feb; 78:43-48 Epub 2020 Dec 08 View PubMed Mukherjee A, Al-Lahham R, Corkins ME, Samanta S, Schmeichel AM, Singer W, Low PA, Govindaraju T, Soto C. Identification of Multicolor Fluorescent Probes for Heterogeneous Abeta Deposits in Alzheimer's Disease. Front Aging Neurosci. 2021; 13:802614 Epub 2022 Feb 03 View PubMed Pellecchia MT, Stankovic I, Fanciulli A, Krismer F, Meissner WG, Palma JA, Panicker JN, Seppi K, Wenning GK, Members of the Movement Disorder Society Multiple System Atrophy Study Group. Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group. Mov Disord Clin Pract. 2020 Oct; 7 (7):750-762 Epub 2020 Sept 03 View PubMed Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Boeve BF, Sletten DM, Gehrking TL, Gehrking JA, Olson AD, Savica R, Suarez MD, Soto C, Low PA. Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies. Ann Neurol. 2020 Sep; 88 (3):503-512 Epub 2020 Aug 01 View PubMed Coon EA, Mandrekar JN, Berini SE, Benarroch EE, Sandroni P, Low PA, Singer W. Predicting phenoconversion in pure autonomic failure. Neurology. 2020 Aug 18; 95 (7):e889-e897 Epub 2020 June 16 View PubMed Figueroa JJ, Cheshire WP, Claydon VE, Norcliffe-Kaufmann L, Peltier A, Singer W, Snapper H, Vernino S, Raj SR, American Autonomic Society. Autonomic function testing in the COVID-19 pandemic: an American Autonomic Society position statement. Clin Auton Res. 2020 Aug; 30 (4):295-297 Epub 2020 June 11 View PubMed McCarter SJ, Coon EA, Savica R, St Louis EK, Bower JH, Benarroch EE, Sandroni P, Low P, Singer W. Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival. Mov Disord. 2020 Aug; 35 (8):1462-1466 Epub 2020 Apr 22 View PubMed McCarter SJ, Gehrking TL, St Louis EK, Suarez MD, Boeve BF, Silber MH, Low PA, Singer W. Autonomic dysfunction and phenoconversion in idiopathic REM sleep behavior disorder. Clin Auton Res. 2020 Jun; 30 (3):207-213 Epub 2020 Mar 19 View PubMed Coon EA, Singer W. Synucleinopathies. Continuum (Minneap Minn). 2020 Feb; 26 (1):72-92 View PubMed Desai A, Low PA, Camilleri M, Singer W, Burton D, Chakraborty S, Bharucha AE. Utility of the plasma pancreatic polypeptide response to modified sham feeding in diabetic gastroenteropathy and non-ulcer dyspepsia. Neurogastroenterol Motil. 2020 Feb; 32 (2):e13744 Epub 2019 Oct 22 View PubMed Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X, Hu B, Schmeichel A, Singer W, Wu G, Tsai AL, Shirani H, Nilsson KPR, Low PA, Soto C. Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy. Nature. 2020 Feb; 578 (7794):273-277 Epub 2020 Feb 05 View PubMed Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR, American Autonomic Society. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res. 2020 Feb; 30 (1):13-18 Epub 2019 Sept 02 View PubMed Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR, American Autonomic Society. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Auton Neurosci. 2020 Jan; 223:102550 View PubMed Corfits J, Singer W, Sandroni P, Fealey RD, Coon EA, Benarroch EE, Berini SE, Mauermann ML, Sletten DM, Cutsforth-Gregory JK, Schmelzer JD, Low PA. Elimination of spurious absent sweat response in QSWEAT recordings. Auton Neurosci. 2019 Dec; 222:102589 Epub 2019 Oct 23 View PubMed McCarter SJ, Feemster JC, Tabatabai GM, Sandness DJ, Timm PC, McCarter AR, Talley HN, Junna MR, Savica R, Singer W, Coon EA, Benarroch EE, Josephs KA, Boeve BF, Silber MH, St Louis EK. Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy. Ann Neurol. 2019 Dec; 86 (6):969-974 View PubMed Coon EA, Singer W, Low PA. Pure Autonomic Failure. Mayo Clin Proc. 2019 Oct; 94 (10):2087-2098 Epub 2019 Sept 09 View PubMed van Gerpen JA, Al-Shaikh RH, Tipton PW, Wszolek ZK, Uitti RJ, Ferman TJ, Dickson DW, Benarroch EE, Singer W, Cutsforth-Gregory JK, Heckman MG, Brushaber DE, Josephs KA, Low PA, Ahlskog JE, Cheshire WP. Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension. Neurology. 2019 Oct 1; 93 (14):e1339-e1347 Epub 2019 Sept 04 View PubMed Jackson L, Coon EA, Ahlskog JE, Bower JH, Sandroni P, Benarroch EE, Mandrekar JN, Low PA, Singer W. Earlier age of onset in multiple system atrophy with smoking and heavy alcohol use. Parkinsonism Relat Disord. 2019 Sep; 66:212-215 Epub 2019 July 17 View PubMed Singer W, Dietz AB, Zeller AD, Gehrking TL, Schmelzer JD, Schmeichel AM, Gehrking JA, Suarez MD, Sletten DM, Minota Pacheco KV, Coon EA, Sandroni P, Benarroch EE, Fealey RD, Matsumoto JY, Bower JH, Hassan A, McKeon A, Windebank AJ, Mandrekar JN, Low PA. Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy. Neurology. 2019 Jul 02; 93(1):e77-e87. Epub 2019 May 31. View PubMed Stankovic I, Quinn N, Vignatelli L, Antonini A, Berg D, Coon E, Cortelli P, Fanciulli A, Ferreira JJ, Freeman R, Halliday G, Hoglinger GU, Iodice V, Kaufmann H, Klockgether T, Kostic V, Krismer F, Lang A, Levin J, Low P, Mathias C, Meissner WG, Kaufmann LN, Palma JA, Panicker JN, Pellecchia MT, Sakakibara R, Schmahmann J, Scholz SW, Singer W, Stamelou M, Tolosa E, Tsuji S, Seppi K, Poewe W, Wenning GK, Movement Disorder Society Multiple System Atrophy Study Group. A critique of the second consensus criteria for multiple system atrophy. Mov Disord. 2019 Jul; 34 (7):975-984 Epub 2019 Apr 29 View PubMed Coon EA, Nelson RM, Sletten DM, Suarez MD, Ahlskog JE, Benarroch EE, Sandroni P, Mandrekar JN, Low PA, Singer W. Sex and gender influence symptom manifestation and survival in multiple system atrophy. Auton Neurosci. 2019 Jul; 219:49-52. Epub 2019 Apr 24. View PubMed Chakraborty S, Halland M, Burton D, Desai A, Neja B, Low P, Singer W, Camilleri M, Zinsmeister AR, Bharucha AE. GI Dysfunctions in Diabetic Gastroenteropathy, Their Relationships With Symptoms, and Effects of a GLP-1 Antagonist. J Clin Endocrinol Metab. 2019 Jun 1; 104 (6):1967-1977 View PubMed Minota K, Schmeichel AM, Gehrking JA, Mandrekar JN, Low PA, Singer W. Refined Quantitation of Sweat Gland Innervation. J Neuropathol Exp Neurol. 2019 May 1; 78 (5):453-459 View PubMed Staff NP, Jones DT, Singer W. Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases. Mayo Clin Proc. 2019 May; 94 (5):892-905 View PubMed Cutsforth-Gregory JK, McKeon A, Coon EA, Sletten DM, Suarez M, Sandroni P, Singer W, Benarroch EE, Fealey RD, Low PA. Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure. Mayo Clin Proc. 2018 Oct; 93(10):1440-1447. Epub 2018 Aug 28. View PubMed Ogaki K, Heckman MG, Koga S, Martens YA, Labbe C, Lorenzo-Betancor O, Walton RL, Soto AI, Vargas ER, Fujioka S, Uitti RJ, van Gerpen JA, Cheshire WP, Younkin SG, Wszolek ZK, Low PA, Singer W, Bu G, Dickson DW, Ross OA. Association study between multiple system atrophy and TREM2 p.R47H. Neurol Genet. 2018 Aug; 4 (4):e257 Epub 2018 Aug 01 View PubMed Ogaki K, Martens YA, Heckman MG, Koga S, Labbe C, Lorenzo-Betancor O, Wernick AI, Walton RL, Soto AI, Vargas ER, Nielsen HM, Fujioka S, Kanekiyo T, Uitti RJ, van Gerpen JA, Cheshire WP, Wszolek ZK, Low PA, Singer W, Dickson DW, Bu G, Ross OA. Multiple system atrophy and apolipoprotein E. Mov Disord. 2018 Apr; 33 (4):647-650 Epub 2018 Feb 14 View PubMed Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC, Singer W, Low PA, Goldstein DS, Gibbons CH, Freeman R, Robertson D, Autonomic Disorders Consortium. Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol. 2018 Mar; 83 (3):522-531 Epub 2018 Mar 10 View PubMed Coon EA, Ahlskog JE, Silber MH, Fealey RD, Benarroch EE, Sandroni P, Mandrekar JN, Low PA, Singer W. Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy? Parkinsonism Relat Disord. 2018 Mar; 48:51-53 Epub 2017 Dec 14 View PubMed Stewart JM, Boris JR, Chelimsky G, Fischer PR, Fortunato JE, Grubb BP, Heyer GL, Jarjour IT, Medow MS, Numan MT, Pianosi PT, Singer W, Tarbell S, Chelimsky TC, Pediatric Writing Group of the American Autonomic Society. Pediatric Disorders of Orthostatic Intolerance. Pediatrics. 2018 Jan; 141 (1) Epub 2017 Dec 08 View PubMed Rasmussen TK, Hansen J, Low PA, Sandroni P, Singer W, Jensen TS, Terkelsen AJ. Autonomic function testing: Compliance and consequences. Auton Neurosci. 2017 Dec; 208:150-155 Epub 2017 Oct 18 View PubMed Singer W, Low PA. Early Orthostatic Hypotension and Orthostatic Intolerance-More Than an Observation or Annoyance. JAMA Intern Med 2017 Sep 1; 177 (9):1324-1325 View PubMed Singer W, Berini SE, Sandroni P, Fealey RD, Coon EA, Suarez MD, Benarroch EE, Low PA. Pure autonomic failure: Predictors of conversion to clinical CNS involvement. Neurology. 2017 Mar 21; 88 (12):1129-1136 Epub 2017 Feb 15 View PubMed Coon EA, Fealey RD, Sletten DM, Mandrekar JN, Benarroch EE, Sandroni P, Low PA, Singer W. Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction. Mov Disord. 2017 Mar; 32(3):397-404. Epub 2016 Nov 10. View PubMed Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D, Autonomic Disorders Consortium. Natural history of pure autonomic failure: A United States prospective cohort. Ann Neurol. 2017 Feb; 81 (2):287-297 View PubMed Loavenbruck AJ, Singer W, Mauermann ML, Sandroni P, Dyck PJ, B Dyck PJ, Gertz M, Klein CJ, Low PA. Transthyretin amyloid neuropathy has earlier neural involvement but better prognosis than primary amyloid counterpart: an answer to the paradox? Ann Neurol. 2016 Sep; 80 (3):401-11 Epub 2016 July 25 View PubMed Labbe C, Heckman MG, Lorenzo-Betancor O, Murray ME, Ogaki K, Soto-Ortolaza AI, Walton RL, Fujioka S, Koga S, Uitti RJ, van Gerpen JA, Petersen RC, Graff-Radford NR, Younkin SG, Boeve BF, Cheshire WP Jr, Low PA, Sandroni P, Coon EA, Singer W, Wszolek ZK, Dickson DW, Ross OA. MAPT haplotype diversity in multiple system atrophy. Parkinsonism Relat Disord. 2016 Sep; 30:40-5 Epub 2016 June 16 View PubMed Coon EA, Fealey RD, Benarroch EE, Sandroni P, Low PA, Singer W. Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. Neurology. 2016 Jun 14; 86 (24):2314 View PubMed Coon EA, Sletten DM, Suarez MD, Mandrekar JN, Ahlskog JE, Bower JH, Matsumoto JY, Silber MH, Benarroch EE, Fealey RD, Sandroni P, Low PA, Singer W. Clinical features and autonomic testing predict survival in multiple system atrophy. Brain. 2015 Dec; 138(Pt 12):3623-31. Epub 2015 Sep 13. View PubMed Low PA, Reich SG, Jankovic J, Shults CW, Stern MB, Novak P, Tanner CM, Gilman S, Marshall FJ, Wooten F, Racette B, Chelimsky T, Singer W, Sletten DM, Sandroni P, Mandrekar J. Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol. 2015 Jul; 14 (7):710-9 Epub 2015 May 27 View PubMed Figueroa JJ, Singer W, Sandroni P, Sletten DM, Gehrking TL, Gehrking JA, Low P, Basford JR. Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension. Arch Phys Med Rehabil. 2015 Mar; 96 (3):505-10 Epub 2014 Nov 06 View PubMed Singer W, Low PA. Optimizing clinical trial design for multiple system atrophy: lessons from the rifampicin study. Clin Auton Res. 2015 Feb; 25 (1):47-52 Epub 2015 Mar 13 View PubMed Loavenbruck A, Iturrino J, Singer W, Sletten DM, Low PA, Zinsmeister AR, Bharucha AE. Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome. Neurogastroenterol Motil. 2015 Jan; 27(1):92-8. Epub 2014 Dec 06. View PubMed Leavitt JA, Singer W, Brown WL, Pulido JS, Brodsky MC. Retinal and pontine striations: neurodiagnostic signs of autosomal recessive spastic ataxia of Charlevoix-Saguenay. J Neuroophthalmol. 2014 Dec; 34(4):369-71. View PubMed Litchy WJ, Albers JW, Wolfe J, Bolton CF, Walsh N, Klein CJ, Zafft AJ, Russell JW, Zwirlein M, Overland CJ, Davies JL, Carter RE, Dyck PJ, CI. Nphys Trial 4 Investigators. Proficiency of nerve conduction using standard methods and reference values (Cl. NPhys Trial 4). Muscle Nerve. 2014 Dec; 50 (6):900-8 Epub 2014 Oct 30 View PubMed Figueroa JJ, Bott-Kitslaar DM, Mercado JA, Basford JR, Sandroni P, Shen WK, Sletten DM, Gehrking TL, Gehrking JA, Low PA, Singer W. Decreased orthostatic adrenergic reactivity in non-dipping postural tachycardia syndrome. Auton Neurosci. 2014 Oct; 185:107-11. Epub 2014 Jun 21. View PubMed Wada N, Singer W, Gehrking TL, Sletten DM, Schmelzer JD, Kihara M, Low PA. Determination of vagal baroreflex sensitivity in normal subjects. Muscle Nerve. 2014 Oct; 50(4):535-40. Epub 2014 Aug 05. View PubMed Wada N, Singer W, Gehrking TL, Sletten DM, Schmelzer JD, Low PA. Comparison of baroreflex sensitivity with a fall and rise in blood pressure induced by the Valsalva manoeuvre. Clin Sci (Lond). 2014 Sep; 127(5):307-13. View PubMed Argyros B, Russell JW, Gahnstrom LE, Nalepa S, Albers JW, Lodermeier KA, Zafft AJ, Dyck PJ, Dyck PJ, Klein CJ, Litchy WJ, Davies JL, Carter RE, Melton LJ 3rd, members of the Cl versus NPhys Trials. Multicenter trial of the proficiency of smart quantitative sensation tests. Muscle Nerve. 2014 May; 49 (5):645-53 Epub 2014 Jan 28 View PubMed Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Mar; 13 (3):268-75 Epub 2014 Feb 05 View PubMed Vincent A, McAllister SJ, Singer W, Toussaint LL, Sletten DM, Whipple MO, Low PA. A report of the autonomic symptom profile in patients with fibromyalgia. J Clin Rheumatol. 2014 Mar; 20(2):106-8. View PubMed Figueroa JJ, Singer W, Parsaik A, Benarroch EE, Ahlskog JE, Fealey RD, Parisi JE, Sandroni P, Mandrekar J, Iodice V, Low PA, Bower JH. Multiple system atrophy: Prognostic indicators of survival. Mov Disord. 2014; 29(9):1151-7. View PubMed Dyck PJ, Albers JW, Wolfe J, Bolton CF, Walsh N, Klein CJ, Zafft AJ, Russell JW, Thomas K, Davies JL, Carter RE, Melton LJ 3rd, Litchy WJ, Clinical vs. Neurophysiology Trial 3 Investigators. A trial of proficiency of nerve conduction: greater standardization still needed. Muscle Nerve. 2013 Sep; 48 (3):369-74 Epub 2013 July 17 View PubMed Park KJ, Singer W, Sletten DM, Low PA, Bharucha AE. Gastric emptying in postural tachycardia syndrome: a preliminary report. Clin Auton Res. 2013 Aug; 23(4):163-7. Epub 2013 May 25. View PubMed Parsaik AK, Singer W, Allison TG, Sletten DM, Joyner MJ, Benarroch EE, Low PA, Sandroni P. Orthostatic intolerance without postural tachycardia: how much dysautonomia? Clin Auton Res. 2013 Aug; 23(4):181-8. Epub 2013 Jun 01. View PubMed Parsaik AK, Ahlskog JE, Singer W, Gelfman R, Sheldon SH, Seime RJ, Craft JM, Staab JP, Kantor B, Low PA. Central hyperadrenergic state after lightning strike. Clin Auton Res. 2013 Aug; 23 (4):169-73 Epub 2013 June 13 View PubMed Klaas JP, Burkholder DB, Singer W, Boes CJ. Harry Lee Parker and paroxysmal dysarthria and ataxia. Neurology 2013 Jan 15; 80 (3):311-4 View PubMed Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W. COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc. 2012 Dec; 87(12):1196-201. View PubMed Dyck PJ, Overland CJ, Low PA, Litchy WJ, Davies JL, Dyck PJ, Dyck PJ, Carter RE, Melton LJ, Andersen H, Melton LJ, Albers JW, Bolton CF, England JD, Klein CJ, Llewelyn G, Mauermann ML, Russell JW, Selvarajah D, Singer W, Smith AG, Tesfaye S, Vella A. "Unequivocally Abnormal" vs "Usual" Signs and Symptoms for Proficient Diagnosis of Diabetic Polyneuropathy: Cl vs N Phys Trial. Arch Neurol. 2012 Dec; 69 (12):1609-14 View PubMed Parsaik A, Allison TG, Singer W, Sletten DM, Joyner MJ, Benarroch EE, Low PA, Sandroni P. Deconditioning in patients with orthostatic intolerance. Neurology. 2012 Oct 02; 79(14):1435-9. Epub 2012 Sep 19. View PubMed Kimpinski K, Figueroa JJ, Singer W, Sletten DM, Iodice V, Sandroni P, Fischer PR, Opfer-Gehrking TL, Gehrking JA, Low PA. A prospective, 1-year follow-up study of postural tachycardia syndrome. Mayo Clin Proc. 2012 Aug; 87(8):746-52. Epub 2012 Jul 15. View PubMed Kimpinski K, Iodice V, Burton DD, Camilleri M, Mullan BP, Lipp A, Sandroni P, Gehrking TL, Sletten DM, Ahlskog JE, Fealey RD, Singer W, Low PA. The role of autonomic testing in the differentiation of Parkinson's disease from multiple system atrophy. J Neurol Sci. 2012 Jun 15; 317(1-2):92-6. Epub 2012 Mar 14. View PubMed Figueroa JJ, Bosch EP, Dyck PJ, Singer W, Vrana JA, Theis JD, Dogan A, Klein CJ. Amyloid-like IgM deposition neuropathy: a distinct clinico-pathologic and proteomic profiled disorder. J Peripher Nerv Syst. 2012 Jun; 17 (2):182-90 View PubMed Iodice V, Lipp A, Ahlskog JE, Sandroni P, Fealey RD, Parisi JE, Matsumoto JY, Benarroch EE, Kimpinski K, Singer W, Gehrking TL, Gehrking JA, Sletten DM, Schmeichel AM, Bower JH, Gilman S, Figueroa J, Low PA. Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests. J Neurol Neurosurg Psychiatry. 2012 Apr; 83(4):453-9. Epub 2012 Jan 06. View PubMed Singer W, Sletten DM, Opfer-Gehrking TL, Brands CK, Fischer PR, Low PA. Postural tachycardia in children and adolescents: what is abnormal? J Pediatr. 2012 Feb; 160(2):222-6. Epub 2011 Oct 11. View PubMed Singer W, Yung IO, Wollmann R, Kelly T, Keegan BM. A middle-aged woman with nausea, weight loss, and orthostatic hypotension. Neurology. 2011 Aug 2; 77(5):489-95. View PubMed Dyck PJ, Overland CJ, Low PA, Litchy WJ, Davies JL, Dyck PJ, O'Brien PC, Cl vs. NPhys Trial Investigators, Albers JW, Andersen H, Bolton CF, England JD, Klein CJ, Llewelyn JG, Mauermann ML, Russell JW, Singer W, Smith AG, Tesfaye S, Vella A. Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial. Muscle Nerve. 2010 Aug; 42(2):157-64. View PubMed Lipp A, Sandroni P, Ahlskog JE, Fealey RD, Kimpinski K, Iodice V, Gehrking TL, Weigand SD, Sletten DM, Gehrking JA, Nickander KK, Singer W, Maraganore DM, Gilman S, Wenning GK, Shults CW, Low PA. Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure. Arch Neurol. 2009 Jun; 66(6):742-50. View PubMed Singer W, Engelstad JK, Dyck PJ. NeuroImages: the beautiful feet of neuropathy. Neurology. 2009 Apr 7; 72(14):1281. View PubMed Vernino S, Sandroni P, Singer W, Low PA. Invited Article: Autonomic ganglia: target and novel therapeutic tool. Neurology. 2008 May 13; 70(20):1926-32. View PubMed Low PA, Singer W. Management of neurogenic orthostatic hypotension: an update. Lancet Neurol. 2008 May; 7 (5):451-8 View PubMed Schrezenmaier C, Singer W, Swift NM, Sletten D, Tanabe J, Low PA. Adrenergic and vagal baroreflex sensitivity in autonomic failure. Arch Neurol. 2007 Mar; 64(3):381-6. View PubMed Singer W, Opfer-Gehrking TL, Nickander KK, Hines SM, Low PA. Acetylcholinesterase inhibition in patients with orthostatic intolerance. J Clin Neurophysiol. 2006 Oct; 23(5):476-81. View PubMed Singer W, Sandroni P, Opfer-Gehrking TL, Suarez GA, Klein CM, Hines S, O'Brien PC, Slezak J, Low PA. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol. 2006 Apr; 63 (4):513-8 Epub 2006 Feb 13 View PubMed Sandroni P, Opfer-Gehrking TL, Singer W, Low PA. Pyridostigmine for treatment of neurogenic orthostatic hypotension [correction of hypertension]--a follow-up survey study. Clin Auton Res. 2005 Feb; 15 (1):51-3 View PubMed Singer W, Spies JM, McArthur J, Low J, Griffin JW, Nickander KK, Gordon V, Low PA. Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies. Neurology. 2004 Feb 24; 62 (4):612-8 View PubMed Singer W, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Bharucha AE, Low PA. Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry. 2003 Sep; 74 (9):1294-8 View PubMed Singer W, Shen WK, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Low PA. Heart rate-dependent electrocardiogram abnormalities in patients with postural tachycardia syndrome. Auton Neurosci. 2003 Jan 31; 103 (1-2):106-13 View PubMed Singer W, Shen WK, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Low PA. Evidence of an intrinsic sinus node abnormality in patients with postural tachycardia syndrome. Mayo Clin Proc. 2002 Mar; 77(3):246-52. View PubMed Singer W, OpferGgehrking TL, McPhee BR, Hilz MJ, Low PA. Influence of posture on the Valsalva manoeuvre. Clin Sci (Lond). 2001 Apr; 100: (4)433-40. View PubMed Tani H, Singer W, McPhee BR, Opfer-Gehrking TL, Haruma K, Kajiyama G, Low PA. Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS). Auton Neurosci. 2000 Dec 28; 86(1-2):107-13. View PubMed Hilz MJ, Hecht M, Berghoff M, Singer W, Neundörfer B. Abnormal vasoreaction to arousal stimuli - an early sign of diabetic sympathetic neuropathy demonstrated by Laser Doppler flowmetry. J Clin Neurophysiol. 2000; 17(4):419-25. Hilz MJ, Stemper B, Sauer P, Haertl U, Singer W, Axelrod FB. Cold face test demonstrates parasympathetic cardiac dysfunction in familial dysautonomia. Am J Physiol. 1999; 276:R1833-9. PST-20538096 Inicio Publicaciones