Publicaciones Imprimir Cheng AS, Li LX, Zhou JX, Harris PC, Calvet JP, Li X. Aldehyde dehydrogenase 1 A1 regulates the transcription of PD-L1 and its targeting with disulfiram together with PD-L1 immunotherapy synergistically delays cyst growth in ADPKD. Kidney Int. 2025 Dec 15. [Epub ahead of print] View PubMed Cheng AS, Li LX, Zhou JX, Harris PC, Calvet JP, Li X. In vivo base editing rescues ADPKD in a humanized mouse model. Nat Commun. 2025 Dec 11; 16(1):11212. View PubMed Mao X, Li L, Lee G, Agborbesong E, Zhou JX, Calvet JP, Li X. Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease. Kidney Int. 2025 Nov; 108 (5):811-826 Epub 2025 June 25 View PubMed Wu J, Cheng AS, Weimbs T, Harris PC, Zhou JX, Li X. GLP-1RA Semaglutide Delays the Progression of ADPKD Through Regulation of Glycolysis, Mitochondria Function and Ketosis. FASEB J. 2025 Aug 31; 39 (16):e70944 View PubMed Wu J, Cheng S, Lee G, Agborbesong E, Li X, Zhou X, Li X. STING Promotes the Progression of ADPKD by Regulating Mitochondrial Function, Inflammation, Fibrosis, and Apoptosis. Biomolecules. 2024 Sep 26; 14 (10) Epub 2024 Sept 26 View PubMed Zhou JX, Li LX, Zhang H, Agborbesong E, Harris PC, Calvet JP, Li X. DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease. Kidney Int. 2024 Aug; 106 (2):258-272 Epub 2024 May 21 View PubMed Agborbesong E, Zhou JX, Zhang H, Li LX, Harris PC, Calvet JP, Li X. SMYD3 Controls Ciliogenesis by Regulating Distinct Centrosomal Proteins and Intraflagellar Transport Trafficking. Int J Mol Sci. 2024 May 30; 25 (11) View PubMed Zhou JX, Cheng AS, Chen L, Li LX, Agborbesong E, Torres VE, Harris PC, Li X. CD74 Promotes Cyst Growth and Renal Fibrosis in Autosomal Dominant Polycystic Kidney Disease. Cells. 2024 Mar 11; 13 (6) View PubMed Agborbesong E, Zhou JX, Zhang H, Li LX, Harris PC, Calvet JP, Li X. Overexpression of SMYD3 Promotes Autosomal Dominant Polycystic Kidney Disease by Mediating Cell Proliferation and Genome Instability. Biomedicines. 2024 Mar 7; 12 (3) Epub 2024 Mar 07 View PubMed Zhang L, Zhang H, Agborbesong E, Zhou JX, Li X. Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis. Cell Death Dis. 2023 Dec 5; 14 (12):795 Epub 2023 Dec 05 View PubMed Zhou JX, Torres V.. Polycystic kidney diseases in adults The Nephrology Self-Assessment Program (NephSAP). 2023. Zhou JX, Torres VE. Autosomal Dominant Polycystic Kidney Disease Therapies on the Horizon. Adv Kidney Dis Health. 2023 May; 30(3):245-260. View PubMed Zhou JX, Torres VE. Drug repurposing in autosomal dominant polycystic kidney disease. Kidney Int. 2023 May; 103 (5):859-871 Epub 2023 Mar 02 View PubMed Yu W, Wang G, Li X, Li LX, Zhang H, Gui X, Zhou JX, Calvet JP, Li X. Transcription factor FoxM1 promotes cyst growth in PKD1 mutant ADPKD. Hum Mol Genet. 2023 Mar 20; 32 (7):1114-1126 View PubMed Agborbesong E, Zhou JX, Li LX, Harris PC, Calvet JP, Li X. Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis. Hum Mol Genet. 2023 Jan 27; 32 (4):567-579 View PubMed Li LX, Zhang X, Zhang H, Agborbesong E, Zhou JX, Calvet JP, Li X. Single-Cell and CellChat Resolution Identifies Collecting Duct Cell Subsets and Their Communications with Adjacent Cells in PKD Kidneys. Cells. 2022 Dec 22; 12 (1) View PubMed Zhou JX, Agborbesong E, Li LX, Li X. Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC Progression. Int J Mol Sci. 2022 Dec 2; 23 (23) Epub 2022 Dec 02 View PubMed Sundar SV, Zhou JX, Magenheimer BS, Reif GA, Wallace DP, Georg GI, Jakkaraj SR, Tash JS, Yu ASL, Li X, Calvet JP. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1; 323 (4):F492-F506 Epub 2022 Aug 18 View PubMed Li LX, Zhang L, Agborbesong E, Zhang X, Zhou JX, Li X. Cross talk between lysine methyltransferase Smyd2 and TGF-beta-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Aug 1; 323 (2):F227-F242 Epub 2022 June 27 View PubMed Agborbesong E, Zhou JX, Li LX, Calvet JP, Li X. Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability. FASEB J. 2022 Jan; 36 (1):e22089 View PubMed Zhou X, Torres VE. Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling. Front Mol Biosci. 2022; 9:981963 Epub 2022 Sept 02 View PubMed Zhou JX, Li X. Non-Coding RNAs in Hereditary Kidney Disorders. Int J Mol Sci. 2021 Mar 16; 22(6). View PubMed Li LX, Zhou JX, Wang X, Zhang H, Harris PC, Calvet JP, Li X. Cross-talk between CDK4/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis. Sci Adv. 2020 Oct; 6 (44) Epub 2020 Oct 30 View PubMed El Ters M, Zhou X, Lepping RJ, Lu P, Karcher RT, Mahnken JD, Brooks WM, Winklhofer FT, Li X, Yu ASL. Biological Efficacy and Safety of Niacinamide in Patients With ADPKD. Kidney Int Rep. 2020 Aug; 5(8):1271-1279. Epub 2020 Jun 10. View PubMed Zhang L, Li LX, Zhou JX, Harris PC, Calvet JP, Li X. RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD. Theranostics. 2020; 10 (18):8281-8297 Epub 2020 July 09 View PubMed Afridi SM, Raja A, Zhou X, Jain A. Calciphylaxis due to metastatic well-differentiated neuroendocrine carcinoma. BMJ Case Rep. 2019 Aug 30; 12 (8) View PubMed Salah SM, Meisenheimer JD, Rao R, Peda JD, Wallace DP, Foster D, Li X, Li X, Zhou X, Vallejo JA, Wacker MJ, Fields TA, Swenson-Fields KI. MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease. Am J Physiol Renal Physiol. 2019 Aug 01; 317(2):F343-F360. Epub 2019 May 15. View PubMed Trott JF, Hwang VJ, Ishimaru T, Chmiel KJ, Zhou JX, Shim K, Stewart BJ, Mahjoub MR, Jen KY, Barupal DK, Li X, Weiss RH. Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis. Am J Physiol Renal Physiol. 2018 Dec 1; 315 (6):F1855-F1868 Epub 2018 Oct 03 View PubMed Li LX, Zhou JX, Calvet JP, Godwin AK, Jensen RA, Li X. Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression. Cell Death Dis. 2018 Feb 27; 9 (3):326 View PubMed Hwang VJ, Zhou X, Chen X, Trott J, Abu Aboud O, Shim K, Dionne LK, Chmiel KJ, Senapedis W, Baloglu E, Mahjoub MR, Li X, Weiss RH. Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease. Kidney Int. 2017 Oct; 92(4):922-933. Epub 2017 May 23. View PubMed Li LX, Fan LX, Zhou JX, Grantham JJ, Calvet JP, Sage J, Li X. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest. 2017 Jun 30; 127 (7):2751-2764 Epub 2017 June 12 View PubMed Kakade VR, Tao S, Rajagopal M, Zhou X, Li X, Yu AS, Calvet JP, Pandey P, Rao R. A cAMP and CREB-mediated feed-forward mechanism regulates GSK3ß in polycystic kidney disease. J Mol Cell Biol. 2016 Dec; 8(6):464-476. Epub 2016 May 04. View PubMed Zhou X, Fan LX, Peters DJ, Trudel M, Bradner JE, Li X. Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. Hum Mol Genet. 2015 Jul 15; 24(14):3982-93. Epub 2015 Apr 15. View PubMed Chen L, Zhou X, Fan LX, Yao Y, Swenson-Fields KI, Gadjeva M, Wallace DP, Peters DJ, Yu A, Grantham JJ, Li X. Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest. 2015 Jun; 125(6):2399-412. Epub 2015 May 11. View PubMed Zhou JX, Fan LX, Li X, Calvet JP, Li X. TNFa signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling. PLoS One. 2015; 10(6):e0131043. Epub 2015 Jun 25. View PubMed Su L, Zhou X, Yuan D, Yang H, Wei D, Qin G, Liang S. Prevalence and patterns of drug-resistance mutations among HIV-1 patients infected with CRF07_BC strains in Sichuan province, China. Virol Sin. 2014 Aug; 29 (4):237-41 Epub 2014 Aug 08 View PubMed Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet. 2014 Mar 15; 23(6):1644-55. Epub 2013 Nov 07. View PubMed Fan LX, Zhou X, Sweeney WE Jr, Wallace DP, Avner ED, Grantham JJ, Li X. Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts. J Am Soc Nephrol. 2013 Dec; 24(12):2010-22. Epub 2013 Aug 29. View PubMed Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul; 123(7):3084-98. Epub 2013 Jun 17. View PubMed Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL. Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+ T cells: T synthase knockdown effects on galectin-1 and CD8+ T cells. J Clin Immunol. 2012 Aug; 32 (4):820-36 Epub 2012 Mar 06 View PubMed Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012; 7 (11):e49418 Epub 2012 Nov 13 View PubMed Zhou X, Liao Q, Ricciardi RP, Peng C, Chen X. Kaposi's sarcoma-associated herpesvirus processivity factor-8 dimerizes in cytoplasm before being translocated to nucleus. Biochem Biophys Res Commun. 2010 Jul 2; 397 (3):520-5 Epub 2010 May 31 View PubMed Zhou J, Zhang Y, Zhou X, Zhou J, Zhang LH, Ye XS, Zhang XL. An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-gamma and IL-4. Bioorg Med Chem. 2008 Feb 15; 16 (4):1605-12 Epub 2007 Nov 17 View PubMed PST-20590084 Inicio Publicaciones