Departments and specialties
Mayo Clinic has one of the largest and most experienced practices in the United States,
with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work
together to ensure quality care and successful recovery.
Departments that treat this condition
Research
Mayo Clinic has been a global leader in research on MGUS, focusing on understanding its biology, risk factors, and progression to multiple myeloma and related plasma cell conditions. Researchers investigate the genetic, molecular and clinical mechanisms underlying MGUS, including chromosomal changes, plasma cell biology and predictors of disease progression.
Mayo Clinic investigators also lead long-term observational studies and clinical trials aimed at identifying biomarkers, improving risk stratification and determining when MGUS is likely to progress to symptomatic disease. Their work has helped shape international guidelines for MGUS monitoring and management while advancing precision medicine approaches for plasma cell conditions.
Researchers at Mayo Clinic coined the term monoclonal gammopathy of undetermined significance (MGUS) in the 1970s and continue to study this condition.
Current research focuses on understanding how risk factors lead to the condition, how these factors might affect treatment, and how to prevent progression to blood cancers and other conditions.
Cancer research is conducted in coordination with the Mayo Clinic Comprehensive Cancer Center. Healthcare professionals and scientists at the center are working on improving the diagnosis and treatment of myeloma and other blood conditions.
Publications
See a list of publications about (MGUS) by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.