Diagnosis

IgA nephropathy is often detected after you notice blood in your urine or when a routine test shows that you have protein or blood in your urine. These tests can help identify which kidney disease you have:

  • Urine tests. Blood or protein in the urine, a possible first sign of IgA nephropathy, might be discovered during a routine checkup. If your doctor suspects that you have problems with your kidneys, you might be asked to collect your urine for 24 hours for additional kidney function tests.
  • Blood tests. If you have kidney disease, a blood test might show increased blood levels of the waste product creatinine.
  • Kidney biopsy. This procedure is the only way for your doctor to confirm a diagnosis of IgA nephropathy. It involves using a special biopsy needle to extract small pieces of kidney tissue for microscopic examination.
  • Iothalamate clearance test. Your doctor may also recommend this test, which uses a special contrast agent to track how well your kidneys are filtering wastes.

Treatment

There's no cure for IgA nephropathy and no sure way of knowing what course your disease will take. Some people need only monitoring to determine whether the disease is getting worse.

For others, a number of medications can slow disease progress and help manage symptoms.

Medications to treat IgA nephropathy include:

  • High blood pressure medications. Taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) can lower your blood pressure and reduce protein loss.
  • Omega-3 fatty acids. These fats, available in dietary fish oil supplements, might reduce inflammation in the glomeruli without harmful side effects. Talk to your doctor before you start supplements.
  • Immunosuppressants. In some cases, corticosteroid medications, such as prednisone, and other potent drugs that suppress the immune response (immunosuppressants) might keep your immune system from attacking your glomeruli. These drugs can cause serious side effects, such as high blood pressure, high blood sugar and increased risk of infection.
  • Statin therapy. If you have high cholesterol, cholesterol-lowering medications can help control it and slow the progression of kidney damage.
  • Diuretics. These help remove extra fluid from your blood. Removing extra fluid can help improve blood pressure control.

The ultimate goal is to avoid the need for kidney dialysis or kidney transplantation. But in some cases, dialysis or transplantation is necessary.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Lifestyle and home remedies

To help keep your kidneys healthier:

  • Take steps to reduce your blood pressure. Keeping your blood pressure levels near normal can help slow kidney damage from IgA nephropathy. Healthy changes in your lifestyle — including limiting your salt intake, losing excess weight, being physically active, using alcohol in moderation and taking your blood pressure medications as prescribed — are ways to keep your blood pressure under control.
  • Monitor your blood pressure at home. Note each reading and bring this record with you to your doctor's appointments.
  • Eat less protein. Reducing the amount of protein you eat and taking steps to decrease your cholesterol levels may help slow the progression of IgA nephropathy and protect your kidneys.

Coping and support

Coping with severe forms of IgA nephropathy can be challenging. But you don't have to do it alone. If you have questions or need guidance, talk with a member of your health care team.

You might also benefit from joining a support group, which can provide both empathetic listening and helpful information. To find out about support groups in your area that deal with kidney disease, ask your doctor. Or contact the National Kidney Foundation (NKF) to learn about NKF Peers, a national, telephone-based peer support program. Call 855-NKF-PEER (855-653-7337) to participate.

Preparing for your appointment

You're likely to start by seeing your primary care doctor. However, you might be referred to a doctor who specializes in treating kidney disorders (nephrologist). Here are some tips for getting ready for your appointment.

What you can do

Ask about pre-appointment restrictions, such as fasting for a blood test, when you make the appointment.

Make a list of:

  • Your symptoms, including any that seem unrelated to the reason for your appointment, and when they began
  • All medications and doses, including over-the-counter drugs, vitamins, herbs or other supplements you take
  • Questions to ask your doctor

Ask a family member or friend to go with you to help you remember the information you receive.

Questions to ask your doctor include:

  • What tests do I need?
  • What's the best course of action? How long will I need medications?
  • Can I manage this disease with diet and lifestyle changes?
  • I have other health conditions. How can I best manage these conditions together?
  • Do you have printed materials on this condition I can have? What websites do you recommend?

What to expect from your doctor

Your doctor is likely to ask you questions, such as:

  • Have your symptoms been continuous or occasional?
  • How severe are your symptoms?
  • Does anything seem to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?

IgA nephropathy (Berger's disease) care at Mayo Clinic

May 17, 2019
References
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  4. IgA nephropathy. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/kidney-disease/iga-nephropathy. Accessed March 27, 2019.
  5. Glomerular diseases. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases. Accessed March 29, 2019.
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  9. Levey AS. GFR as the "gold standard": Estimated, measured, and true. American Journal of Kidney Diseases. 2016;67:9.