Chronic lymphocytic leukemia care at Mayo Clinic

Mayo Clinic hematologists have extensive experience providing personalized care for people with chronic lymphocytic leukemia.

Your Mayo Clinic care team

At Mayo Clinic, experts from many specialties work together as a multidisciplinary team. This team approach means you'll receive comprehensive care that takes into account all of your needs and goals.

Your care team is led by a hematologist who specializes in chronic lymphocytic leukemia. A Mayo Clinic study found people who were cared for by doctors who focus solely on chronic lymphocytic leukemia had longer overall survival than those who were treated by hematologists and oncologists who manage many types of cancers.

Your care team may include:

At Mayo Clinic, hematologists who specialize in chronic lymphocytic leukemia meet every morning to discuss cases. By combining their years of experience, this team draws on their collective knowledge to be certain that each person with chronic lymphocytic leukemia receives an effective, personalized treatment plan.

Specialized care for newly diagnosed cancer

Most people diagnosed with chronic lymphocytic leukemia don't need treatment right away. At Mayo Clinic, these people are actively cared for using the latest protocols for active surveillance and management of complications.

If your cancer doesn't require immediate treatment, you can expect:

  • Regular appointments with a specialist. For most people, Mayo Clinic recommends appointments every three to six months. A chronic lymphocytic leukemia specialist will review your test results with you and discuss your concerns.
  • Comprehensive assessment of disease. Proven laboratory techniques are used to determine your risk of progression. The comprehensive assessment of disease, which is provided for each person with chronic lymphocytic leukemia, uses a combination of laboratory tests and physical examination to determine the risk that you'll need treatment.
  • Management of complications. People with chronic lymphocytic leukemia receive the recommended vaccinations to help manage infection risk. Appropriate cancer screenings are used to manage the increased risk of additional types of cancer.
  • Clinical trials for early interventions. People who don't require immediate treatment are encouraged to join clinical trials studying early interventions.

Innovative treatments for all stages of disease

Mayo Clinic offers cutting-edge treatment along the entire spectrum of chronic lymphocytic leukemia, including the newly diagnosed who require treatment, those for whom other treatments haven't worked, people whose cancer returns after a period of remission, and those with Richter's syndrome.

In addition to established treatments, clinical trials investigating the latest treatments are available for all stages of disease.

Specialists at Mayo Clinic were the first to publish results on the effectiveness of the immunotherapy drug pembrolizumab (Keytruda) for people with chronic lymphocytic leukemia and Richter's syndrome.

Experience you can trust

Mayo Clinic hematologists have extensive experience caring for people with chronic lymphocytic leukemia. Each year, more than 2,300 people with the disease receive care.

Cancer care and research is coordinated through the Mayo Clinic Cancer Center, which meets strict standards for a National Cancer Institute comprehensive cancer center. This designation recognizes scientific excellence and a multidisciplinary approach to cancer prevention, diagnosis and treatment.

Dedication to improving chronic lymphocytic leukemia care

Mayo Clinic hematologists are actively studying new ways to diagnose and treat chronic lymphocytic leukemia. Examples include:

  • Managing a patient database to help doctors track outcomes and detect trends in treatment complications. The chronic lymphocytic leukemia research program has been compiling patient data since 1995, tracking thousands of patients before, during and after treatment.
  • Actively participating in clinical trials studying all aspects of this cancer, including early interventions for people with low-risk disease and the latest treatments for newly diagnosed and relapsed disease.
  • Investigating cutting-edge treatments including chimeric antigen receptor (CAR) T cell therapy, which takes your germ-fighting T cells, engineers them to attack cancer cells, and infuses the cells back into your body.

Chronic lymphocytic leukemia research is supported by a Specialized Program of Research Excellence (SPORE) grant for lymphoma funded by the National Cancer Institute. To earn a highly competitive SPORE grant, institutions must demonstrate a high degree of collaboration between first-rate scientists and clinicians and show excellence in translational research projects.

Expertise and rankings

Mayo Clinic hematologists are respected for their expertise and experience in diagnosing and treating chronic lymphocytic leukemia.

Nationally recognized expertise

Outside organizations regularly recognize Mayo Clinic chronic lymphocytic leukemia specialists through accreditations, grants and rankings, including:

  • Mayo Clinic Cancer Center meets strict standards for a National Cancer Institute comprehensive cancer center, recognizing scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.
  • Mayo Clinic is one of only a few select medical centers in the country to be recognized by a Specialized Program of Research Excellence (SPORE) grant for lymphoma, funded by the National Cancer Institute. To earn a highly competitive SPORE grant, institutions must demonstrate a high degree of collaboration between first-rate scientists and clinicians and show excellence in translational research projects.
  • Mayo Clinic doctors contribute to and collaborate with colleagues around the world through the Chronic Lymphocytic Leukemia Research Consortium.

Mayo Clinic in Rochester, Minn., Mayo Clinic in Jacksonville, Fla., and Mayo Clinic in Scottsdale, Ariz., are ranked among the Best Hospitals for cancer by U.S. News & World Report.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.