Marfan Syndrome and Thoracic Aorta Clinic Overview

People with suspected or known inherited aortic disorders, including Marfan syndrome, find comprehensive, specialized care at the Marfan Syndrome and Thoracic Aorta Clinic at Mayo Clinic in Arizona and Minnesota. In Florida people with Marfan syndrome are seen at the Adult Congenital Heart Disease Clinic.

New medical and surgical treatments are being developed for Marfan syndrome and related disorders. Advances in medical and surgical care have greatly improved life expectancy for people with these conditions. Proper treatment requires accurate genetic evaluation, as medical and surgical decision-making is increasingly driven by genetic diagnosis.

The Marfan Syndrome and Thoracic Aorta Clinic is staffed by a multidisciplinary team of doctors trained in heart conditions (cardiologists), heart and blood vessel surgery (cardiovascular surgeons), cardiac imaging, hereditary conditions (medical geneticists), eye conditions (ophthalmologists) and bone and muscle surgery (orthopedic surgeons). They work together to create a treatment plan that meets your needs. It may include medicine, genetic and reproductive counseling, lifestyle changes, and surgery.

Doctors trained in treating children with medical conditions (pediatricians) and heart conditions (pediatric cardiologists) provide care for children with Marfan syndrome and related disorders at Mayo Clinic in Minnesota.

Advanced diagnosis and treatment

Conditions diagnosed and treated at the Marfan Syndrome and Thoracic Aorta Clinic include:

Your comprehensive care plan may involve the following:

  • Noninvasive cardiovascular imaging.
  • Advanced cardiovascular biomarker testing.
  • Genetic testing and counseling.
  • Pregnancy counseling and family planning.
  • Risk stratification.
  • Advanced cardiovascular lab testing.
  • Medical treatments.
  • Cardiac surgery.

Depending on your situation, your treatment also may involve care for musculoskeletal system problems, vision problems and chronic pain.

Innovative research

Mayo Clinic researchers are working to improve diagnostic tests, genetic testing and treatment of Marfan syndrome. Doctors also research new surgical techniques and the outcomes of surgical treatments for Marfan syndrome and other inherited aortic disorders.


You may be referred by your primary doctor, or you may make an appointment without a referral. Not all services are available at all locations. Please confirm when you contact us for an appointment.

Nationally recognized expertise

Mayo Clinic is top-ranked in more specialties than any other hospital and has been recognized as an Honor Roll member according to the U.S. News & World Report's 2023-2024 "Best Hospitals" rankings.

Mayo Clinic campuses are nationally recognized for expertise in cardiology and cardiovascular surgery:

  • Mayo Clinic in Rochester, Minn., Mayo Clinic in Phoenix/Scottsdale, Ariz., and Mayo Clinic in Jacksonville, Fla., are ranked among the Best Hospitals for heart and heart surgery by U.S. News & World Report.
  • Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2023–2024 "Best Children's Hospitals" rankings.